1. Differential Inductive Sensor for Continuous Non-Invasive Cell Growth Monitoring in Disposable Bioreactors
- Author
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Tamanna Nagraik, Maria Allers, Marc Berger, Kai Bakes, Dörte Solle, Thomas Scheper, Tobias Reinecke, and Stefan Zimmermann
- Subjects
Permittivity ,Materials science ,Scattering ,Linear variable differential transformer ,single use bioreactor ,lcsh:A ,Dewey Decimal Classification::600 | Technik ,Signal ,Magnetic flux ,Single-use bioreactor ,Dielectric spectroscopy ,Electronic engineering ,lcsh:General Works ,Inductive sensor ,cell growth monitoring ,Biological system ,ddc:600 ,inductive permittivity measurements ,dielectric spectroscopy ,differential transformer - Abstract
In this work, we present a low-cost sensor system for continuous non-invasive cell growth monitoring, especially for single use bioreactor (SUB) applications. The sensor system is based on a differential transformer. Using this differential setup, the influence of the primary magnetic flux is eliminated from the measuring signal, enabling highly sensitive non-invasive detection of permittivity changes in the culture medium. To evaluate the sensor, E. coli cultivations are performed and the cell density is measured through the polymer foil of a SUB. We found a linear dependency with low data scattering between measuring signal and cell density.
- Published
- 2017