1. Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: histopathological and immunohistochemical study.
- Author
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Kim JH, Im KS, Kim NH, Yhee JY, Nho WG, and Sur JH
- Subjects
- Animals, Dog Diseases pathology, Dogs, Female, Genetic Markers, Immunohistochemistry veterinary, Lymphocytes, Tumor-Infiltrating pathology, Mammary Neoplasms, Animal pathology, Neoplasm Grading veterinary, Dog Diseases genetics, Gene Expression Regulation, Neoplastic, Mammary Neoplasms, Animal genetics, Receptor, ErbB-2 genetics, Receptor, ErbB-3 genetics
- Abstract
HER-2 and HER-3 are transmembrane receptor proteins that are considered to be important but poorly understood biomarkers in canine tumors. In this study, the expression and the localization of HER-2 and HER-3 were evaluated immunohistochemically in canine mammary tumors (n=64; 12 benign, 52 malignant). HER-2 overexpression was identified in 2/12 (16.7%) benign and in 18/51 (35.3%) malignant cases. HER-3 was expressed in a non-nuclear localization in 11/12 (91.7%) benign and 18/52 (34.6%) malignant tumors. In contrast, HER-3 was expressed in the nucleus of neoplastic cells in 0/12 (0%) benign and 22/52 (42.3%) malignant tumors. Nuclear HER-3 expression was higher in neoplastic epithelial cells compared to myoepithelial cells, and positively correlated with high histological grade and lymphatic vessel invasion. These results suggest that nuclear HER-3 expression is significantly associated with tumor progression and metastasis and may serve as a useful prognostic biomarker in canine malignant mammary tumors., (Copyright © 2010 Elsevier Ltd. All rights reserved.)
- Published
- 2011
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