1. Kupffer cell and apoptosis in experimental HCC
- Author
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Hai-Zhen Zhu, Zhongbi Wu, Youbing Ruan, and Chunming Zhang
- Subjects
Pathology ,medicine.medical_specialty ,TUNEL assay ,biology ,business.industry ,Kupffer cell ,Zymosan ,Gastroenterology ,General Medicine ,medicine.disease ,Proliferating cell nuclear antigen ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Terminal deoxynucleotidyl transferase ,Apoptosis ,Hepatocellular carcinoma ,medicine ,Cancer research ,biology.protein ,Brief Reports ,Liver cancer ,business - Abstract
Our previous study has proved that Kupffer cells may have an inhibitory effect on the process of hepatocarcinogenesis[1], however, their inhibitory mechanism needs exploring deeply. We performed a comparative study on the expression of PCNA, Bax, p53 and apoptosis of liver cancer cells using immunohistochemical technology and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-dig oxigenin nick end labeling (TUNEL) in the diethylnitrosamine-induced hepatocellular carcinoma (HCC) in rats with or without pretreatment with gadolinium chloride or zymosan which might effectively block or enhance the activity of Kupffer cells in order to know the role of Kupffer cells in apoptosis in the experimental HCC and explore further the inhibitory mechanism of Kupffer cells on the process of hepatocarcinogenesis.
- Published
- 2000
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