1. Updates on antibody-mediated rejection in intestinal transplantation
- Author
-
Guo-Sheng Wu
- Subjects
medicine.medical_specialty ,Outcomes ,030230 surgery ,03 medical and health sciences ,0302 clinical medicine ,Clinical investigation ,Medicine ,Intensive care medicine ,Transplantation ,biology ,business.industry ,Hyperacute rejection ,Donor specific antibodies ,Donor-specific antibodies ,Minireviews ,Intestinal transplantation ,Chronic rejection ,Antibody-mediated rejection ,Immunology ,Antibody mediated rejection ,biology.protein ,C4d deposition ,030211 gastroenterology & hepatology ,Antibody ,business - Abstract
Antibody-mediated rejection (ABMR) has increasingly emerged as an important cause of allograft loss after intestinal transplantation (ITx). Compelling evidence indicates that donor-specific antibodies can mediate and promote acute and chronic rejection after ITx. However, diagnostic criteria for ABMR after ITx have not been established yet and the mechanisms of antibody-mediated graft injury are not well-known. Effective approaches to prevent and treat ABMR are required to improve long-term outcomes of intestine recipients. Clearly, ABMR after ITx has become an important area for research and clinical investigation.
- Published
- 2016