Search

Cell coating with human embryonal fibroblasts was examined on solid (Plathurane UM 8300) and microporous (Tecoflex 80 A) polyurethane. Using measurements of cellular growth kinetics and adhesion strength it was found that the onset of cellular growth on the microporous material was delayed but that the vitality and adhesion strength of the cells were better than for the solid material.

Polyurethane non woven membranes with microporous inner layer and macroporous outer layer where tested bacteriologically and histologically. It was proved that the macroporous layer is suitable for the ingrowth and maturing of connective tissue, while the microporous structure prevents the invasion of bacteria, nevertheless being permeable for nutrient substances. So the material could be yield favourable presupposition to achieve bioincorporation in contaminated borderlines.

Morphometric investigations on trachea kinetics in man and beagle dogs were undertaken to find out the range of motility in different moving planes. The results show a special mechanism of load distribution over the whole organ during movement. The minimal and the mean values for bending and torsion were recorded and made reproducible for to examine a trachea prosthesis in laboratory tester on its suitability for organ replacement.

The development of a tracheal prosthesis was evaluated using in vivo data on mechanical loads in the natural organ. The application of in vivo loads to the explanted organ in a laboratory tester was shown to give information on the natural reaction forces of the organ. It is therefore possible to perform in vitro tests on various prosthesis prototypes under near-natural stress conditions and to adapt the prostheses accordingly before implantation.