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Tam Metin / Full Text ESCI PMID: 34177289 WOS:000660311100004 Arterial stiffness is related to arteriolosclerotic diseases and is a marker of adverse cardiovascularevents. Mitral annular calcification (MAC) is progressive calcium deposition on the posterior and inferior mitral annulus and is associated with atherosclerotic cardiovascular diseases. Cardio-ankle vascular index (CAVI)is a measurement technique used to estimate the degree of arterial stiffness without effect from blood pressure. The aim of this study is to research arterial stiffness using CAVI in patients with MAC.Materials and Methods: The study was cross-sectional and observational and included 98 patients with MACconfirmed by echocardiography who referred to the cardiology clinics and met study inclusion criteria and 38controls without MAC. CAVI measurements were obtained by using the Vascular Screening System VaSeraVS-1000 (Fukuda Denshi, Tokyo, Japan) device.Results: The two groups were similar in terms of demographic characteristics, including age, sex, hypertension, coronary artery disease, body surface area, and smoking (P > .05). Left atrial volume index wassignificantly higher in patients with MAC compared with the control group (P < .001). Right arm CAVI, leftarm CAVI, and mean CAVI were significantly higher in the MAC group than the control group (P = .037, P= .005, and P = .014, respectively) and increased with MAC severity. There was a significant positive correlation between mean CAVI and MAC grade (r = 0.278, P = .001). Also, when ankle-brachial index (ABI) wasmeasured with CAVI, left and right extremity ABI values were significantly lower in patients with MAC (P =.017 and P = .005, respectively).Conclusion: CAVI increased in all patients with MAC and associated with increasing grade of calcification

OBJECTIVE It is important to know the elapsed symptom-to-door (StD) time between the emergence of ST-elevation myocardial infarction (STEMI) symptoms and admission to the hospital in terms of the selection of appropriate treatment and prognosis. In this study, we aimed to assess the relationship between serum C-reactive protein (CRP) and StD time after STEMI. METHODS 436 of the patients admitted to our center with STEMI between August 2012-February 2013 (338 male, mean age, 63.9±12.8) were included in this prospective-observational cohort study. Blood samples were obtained from laboratory results of the first reference period. Patients were divided into four groups according to the duration of StD time [0-1. hour; group 1 (G1), 1-3. hour; group 2 (G2), 3-6. hour; group 3 (G3), 6-12. hour; group 4 (G4)]. Statistical analysis was performed via chi-squre test, ANOVA test, Pearson's correlation analysis and receiver operator charecteristic (ROC) analysis. RESULTS As the time progressed, an increase in CRP levels was observed. The difference among the means of the G1-G3 (p=0.002), G1-G4 (p

OBJECTIVE The relationship between silent neuronal injury (SNI) and arterial stiffness assessed by cardio-ankle vascular index (CAVI) has not been evaluated in patients treated with coronary angiography and intervention due to acute coronary syndrome (ACS). The aim of this study is to evaluate the value of CAVI in prediction of SNI after percutaneous coronary angiography and intervention in patients presented with ACS. METHODS Eighty-three consecutive patients presented with ACS, who underwent percutaneous coronary angiography and intervention, were included in this prospective observational study on diagnostic accuracy. Neuron specific enolase (NSE) was studied before and 18 hour after the coronary angiography and intervention. CAVI was measured by VaSera-1000 instrument. Clinical and echocardiographic characteristics were analyzed and independent predictors of SNI were evaluated. Chi-square, Student t-test, Mann-Whithney U test, correlation analysis and logistic regression analysis was used for statistical analysis. RESULTS NSE levels significantly increased after cardiac catheterization (9.82±3.22 mg/dL vs. 13.15±8.55 mg/dL, p

Paravalvular leaks (PVLs) commonly occur in mitral prostheses. Real-time 3-dimensional transesophageal echocardiography (RT-3D TEE) may provide invaluable information about complex 3D anatomy of mitral PVLs compared to two-dimensional (2D) TEE findings. We, herein, aimed to evaluate the detailed description of anatomical characteristics of severe mitral PVLs using RT-3D TEE.Patients with diagnosis of severe mitral PVLs were simultaneously examined with 2D transthoracic echocardiography (TTE), 2D TEE, and RT-3D TEE. 3D characteristics of PVLs (localization, number, size, shape, etc.) were recorded and compared to 2D findings. Results were also compared with surgical findings.The study comprised 47 cases (3 bioprosthesis, 44 mechanical) with 61 severe mitral PVLs. The most common PVL localizations were anterolateral commissure, posteromedial commissures and posterolateral region. The mean PVL width measured by 2D TEE was 3.1±1.3 (range; 2-7) mm and the mean width of defect measured by 3D TEE was 3.1±1.1 (range; 2-7) mm (p=0.7). The mean length of defect measured by 3D TEE was 11.1±6.5 mm. The most common defect type was 'oval/round' shaped (n=29; 48%). There were also 19 'crescentic' (31%), 9 'slit like' (15%), and 2 tunnel-like shaped defects. In 22 patients, the site and dimension of the PVLs were all confirmed surgically.RT-3D TEE permits detailed structural evaluation of the prosthesis and description of paravalvular leak morphology compared to 2D TEE. It may provide more accurate information to the clinician in decision making and may contribute to the success of the potential corrective procedures.AMAÇ: Paravalvüler kaçaklar (PVK) genellikle mitral protez kapaklarda görülür. Gerçek zamanlı üç-boyutlu transözofageal ekokardiyografi (GZ-3B TÖE) iki boyutlu transözofageal ekokardiyografi (2B TÖE) ile kıyaslandığında mitral protez kapağın kompleks 3B anatomisi hakkında paha biçilmez bilgiler sunar. Bu çalışmada GZ-3B TÖE'yi kullanarak ileri mitral PVK'ların detaylı anatomik özelliklerini incelemeyi hedefledik. YÖNTEMLER: İleri PVK'sı olan hastalar eş zamanlı 2B transtorasik ekokardiyografi, 2B TÖE ve GZ-3B TÖE ile incelendi. PVK'ların 3B özellikleri (yerleşimi, boyutları, şekilleri, sayıları vs.) kaydedildi ve 2B görüntülerle kıyaslandı. Sonuçlar cerrahi bulgularla da kıyaslandı.Çalışma 47 mitral protez kapak hastasını (3 biyoprotez, 44 mekanik) ve toplam 61 PVK'yı kapsıyordu. En sık PVK yerleşimi anterolateral komissür, posteromediyal komissür ve posterolateral bölge idi. 2B TÖE ve 3B ile ölçülen ortalama defekt eni sırasıyla 3,1±1,3 (aralık; 2-7) mm ve 3,1±1,1 (aralık; 2-7) mm idi (p=0,7). 3B TÖE ile ölçülen defekt uzunluğu ise 11,1±6,5 mm idi. En sık defekt türü 'oval/yuvarlak' (n=29; %48) idi. Ayrıca 19 hilal şekilli (%31), 9 kesik şekilli (%15) ve 2 tünel-tipi şekil saptandı. PVK yeri ve boyutları 22 hastada cerrahi ile doğrulandı. SONUÇ: GZ-3B TÖE, 2B TÖE'e nazaran protez kapağın yapısal özelliklerinin ve defekt morfolojisinin detaylı incelenmesine olanak tanır. Klinisyene klinik karar verme aşamasında daha doğru bilgiler sunabilir ve olası girişimsel işlemlerin başarısını arttırabilir.