1. Combined infliximab and methotrexate treatment improves the depressive state in rheumatoid arthritis patients more effectively than methotrexate alone
- Author
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Airi Nishimi, T. Tokunaga, Yusuke Miwa, Mayu Saito, Shinichiro Nishimi, Ryo Takahashi, Ryo Yanai, Michio Hosaka, Tsuyoshi Kasama, and Kuninobu Wakabayashi
- Subjects
musculoskeletal diseases ,Methotrexate treatment ,medicine.medical_specialty ,business.industry ,Therapeutic effect ,medicine.disease ,Gastroenterology ,Infliximab ,Bioavailability ,Internal medicine ,Rheumatoid arthritis ,Immunology ,medicine ,Methotrexate ,skin and connective tissue diseases ,business ,Depression (differential diagnoses) ,After treatment ,Original Investigation ,medicine.drug - Abstract
Objective: Rheumatoid arthritis (RA) patients have a greater depressive tendency than normal subjects, and infliximab is known to provide quick therapeutic effects and to have high bioavailability for RA. We therefore investigated whether the depressive state of RA patients would be improved by infliximab. Material and Methods: The Self-Rating Depression Scale (SDS) was used to evaluate 34 RA patients before and 14 or 30 weeks after inflixi mab treatment using the SDS and Disease Activity Score (DAS) 28. The SDS and DAS28 results before and after treatment were compared. Results: We also included 42 cases treated with methotrexate as the control group. The SDS decreased in both groups, and the intraindividual vari ability was p
- Published
- 2014
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