1. The effect of nystatin solution on otoacoustic emissions in rats
- Author
-
Ramazan Gündoğdu, İsmail Külahli, Mesut Aydın, Hacı Okuducu, Turan Arli, Alperen Vural, Mehmet İlhan Şahin, Denizhan Dizdar, and Dizdar, Denizhan
- Subjects
Nystatin ,Antifungal Agents ,Tympanic Membrane ,Gentamycin ,medicine.medical_treatment ,Otoacoustic Emissions, Spontaneous ,Otoacoustic emission ,Otomycosis ,Positive control ,Ear, Middle ,03 medical and health sciences ,Random Allocation ,Ototopical Medications ,0302 clinical medicine ,Ototoxicity ,medicine ,otorhinolaryngologic diseases ,Animals ,In patient ,030223 otorhinolaryngology ,Saline ,Antifungals ,Tympanic Membrane Perforation ,business.industry ,General Medicine ,medicine.disease ,Anti-Bacterial Agents ,Cochlea ,Rats ,Disease Models, Animal ,medicine.anatomical_structure ,Otorhinolaryngology ,Anesthesia ,Middle ear ,sense organs ,Gentamicins ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
DIZDAR, DENIZHAN/0000-0002-0991-2706; DIZDAR, DENIZHAN/0000-0002-0991-2706; Sahin, Mehmet I/0000-0002-9576-1448; Vural, Alperen/0000-0003-1969-7760 WOS:000402429700021 PubMed: 27819649 OBJECTIVE: In patients with a perforated tympanic membrane, topically administered medication reaches the middle ear and thus creates a risk of ototoxicity. The aim of the present study was to evaluate the possible ototoxic effect of the antifungal medication nystatin when administered to the rat middle ear cavity. MATERIALS and METHODS: Three groups (negative control, positive control, and study groups), each containing eight rats, were formed. Before the drug administration, distortion product otoacoustic emissions were recorded in both ears of each rat. Saline (0.09% NaCl), gentamycin, and nystatin solutions were transtympanically injected into the middle ear cavities of the negative control, positive control, and study groups, respectively, for five consecutive days. Seven days after the last infiltration, the control otoacoustic emission was measured, and the data of the 2, 3, 4, 6, 8 kHz frequencies were statistically analyzed. RESULTS: There were no significant changes between the 1st and 2nd measures in the negative control group (0.09% NaCl) (p>0.05), whereas there were significant changes between the 1st and 2nd measures in the positive control group (gentamycin) and study group (nystatin) (p
- Published
- 2017