1. Latent Tuberculosis Infection Management in Solid Organ Transplantation Recipients: A National Snapshot
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Aylin Özgen Alpaydın, Tuba Yeter Turunç, Vildan Avkan-Oğuz, Füsun Öner-Eyüboğlu, Elif Tükenmez-Tigen, İmran Hasanoğlu, Güle Aydın, Yasemin Tezer-Tekçe, Seniha Şenbayrak, Filiz Kızılateş, Adalet Altunsoy Aypak, Sibel Altunışık-Toplu, Pınar Ergen, Behice Kurtaran, Meltem Işıkgöz Taşbakan, Ayşegül Yıldırım, Serkan Yıldız, Kenan Çalışkan, Ebru Ayvazoğlu, Ender Dulundu, Ebru Şengül Şeref Parlak, İrem Akdemir, Melih Kara, Sinan Türkkan, Kübra Demir-Önder, Ezgi Yenigün, Aslı Turgut, Sabahat Alışır Ecder, Saime Paydaş, Tansu Yamazhan, Tufan Egeli, Rüya Özelsancak, Arzu Velioğlu, Mehmet Kılıç, Alpay Azap, Erdal Yekeler, Tuğrul Çakır, Yaşar Bayındır, Asiye Kanbay, Ferit Kuşcu, Kemal Osman Memikoğlu, Nazan Şen, Erhan Kabasakal, and Gülden Ersöz
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Medicine - Abstract
OBJECTIVE: Latent tuberculosis infection (LTBI) screening is strongly recommended in the pre-transplant evaluation of solid organ transplant (SOT) recipients, although it remains inadequate in many transplant centers. We decided to investigate pre-transplant TB risk assessment, LTBI treatment, and registry rates in Turkey. MATERIAL AND METHODS: Adult SOT recipients who underwent tuberculin skin test (TST) and/or interferon-gamma release test (IGRA) from 14 centers between 2015 and 2019 were included in the study. An induration of ≥5 mm on TST and/or probable/positive IGRA (QuantiFERON-TB) was considered positive for LTBI. Demographic features, LTBI screening and treatment, and pre-/post-transplant TB history were recorded from the electronic database of transplantation units across the country and pooled at a single center for a unified database. RESULTS: TST and/or IGRA were performed in 766 (33.8%) of 2266 screened patients most of whom were kidney transplant recipients (n = 485, 63.4%). LTBI screening test was positive in 359 (46.9%) patients, and isoniazid was given to 203 (56.5%) patients. Of the patients treated for LTBI, 112 (55.2%) were registered in the national registry, and 82 (73.2%) completed the treatment. Tuberculosis developed in 6 (1.06%) of 563 patients who were not offered LTBI treatment. CONCLUSION: We determined that overall, only one-third of SOT recipients in our country were evaluated in terms of TB risk, only 1 of the 2 SOT recipients with LTBI received treatment, and half were registered. Therefore, we want to emphasize the critical importance of pretransplant TB risk stratification and registration, guided by revised national guidelines.
- Published
- 2024
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