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2. Chlorbutol toxicity and dependence.

Author

Borody T, Chinwah PM, Graham GG, Wade DN, and Williams KM

Subjects
Adult, Chlorobutanol metabolism, Humans, Male, Chlorobutanol adverse effects, Substance-Related Disorders
Abstract

A case of chlorbutol toxicity and dependence is presented. A very long elimination half-life (13.2 days) was found in the patient. The data suggest that chlorbutol is an unsuitable sedative to be available freely to the public.

Published
1979
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3. Monitoring plasma concentrations of drugs.

Author

Graham GG, Chinwah P, Kennedy M, and Wade DN

Subjects
Anti-Arrhythmia Agents blood, Anticonvulsants blood, Dosage Forms, Humans, Pharmaceutical Preparations administration & dosage, Poisoning, Pharmaceutical Preparations blood
Published
1980
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4. Clinical pharmacokinetics.

Author

Graham GG and Kennedy M

Subjects
Administration, Oral, Body Fluid Compartments, Drug Administration Schedule, Half-Life, Humans, Mathematics, Metabolic Clearance Rate, Models, Biological, Pharmaceutical Preparations administration & dosage, Pharmaceutical Preparations metabolism
Published
1979
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5. Drug metabolism.

Author

Graham GG and Kennedy M

Subjects
Acetylation, Biotransformation, Endoplasmic Reticulum metabolism, Glucuronates metabolism, Humans, Hydrolysis, Oxidation-Reduction, Pharmaceutical Preparations metabolism
Published
1979
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6. Pharmacokinetics and metabolism of non-steroidal anti-inflammatory drugs.

Author

Graham GG

Subjects
Aspirin metabolism, Aspirin pharmacokinetics, Biotransformation, Blood Proteins metabolism, Drug Interactions, Half-Life, Humans, Protein Binding, Synovial Fluid metabolism, Anti-Inflammatory Agents, Non-Steroidal metabolism, Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Published
1987

7. Drug absorption and bioavailability.

Author

Graham GG and Kennedy M

Subjects
Drug Interactions, Food, Humans, Lipids, Liver metabolism, Solubility, Biological Availability, Intestinal Absorption, Pharmaceutical Preparations metabolism
Published
1978
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8. Multiple drug interactions with phenytoin.

Author

Birkett DJ, Graham GG, Chinwah PM, Wade DN, and Hickie JB

Subjects
Alcoholism complications, Epilepsy complications, Female, Humans, Middle Aged, Substance Withdrawal Syndrome complications, Alcoholism blood, Disulfiram, Epilepsy blood, Phenytoin blood, Substance Withdrawal Syndrome blood
Abstract

A 49-year-old female with chronic alcoholism and epilepsy, treated with phenytoin, began to convulse when treatment with disulfiram (an inhibitor of phenytoin metabolism) was discontinued. The patient at this stage was resistant to the large doses of phenytoin, apparently owing to induction of the metabolism of this drug by chronic alcohol intake. Later, a small (30%) increase in dose resulted in about a tenfold increase in plasma concentration of phenytoin and severe toxicity. The final dose of phenytoin required to maintain the plasma level within the therapeutic range suggested that the enzyme induction had decreased. The value of monitoring plasma concentrations of phenytoin is emphasized.

Published
1977
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