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A simple, rapid, accurate and precise spectrophotometric method has been developed for simultaneous estimation of Montelukast Sodium and Fexofenadine HCl in Pure and tablet dosage form. Proposed method involves formation of 'simultaneous equations' at 259.60nm for Fexofenadine Hydrochloride and 283.00 nm for Montelukast Sodium using methanol as a solvent. The linearity was observed in the concentration range of 30-120 mg/ml for Fexofenadine HCl and 6-20 mg/ml for Montelukast Sodium. The correlation coefficient was found to be 0.9927 for fexofenadine HCl and 0.9985 for Montelukast Sodium. Thus the proposed method is reproducible which can be suitably applied for the estimation of FEXO &MONT in combined dosage forms. The results of analysis have been validated statistically and by recovery studies. [ABSTRACT FROM AUTHOR]

The aim of the study is to develop and validate a simple, precise and rapid high performance thin layer chromatographic (HPTLC) method for Cefpodoxime Proxetil and Ofloxacin in bulk and combined tablet dosage form. Chromatographic separation was accomplished by using precoated silica gel 60F TLC plate (20cm x10cm) with 250Ām thickness with mobile phase Chloroform in ratio methanol (9:1 v/v). Detection was performed at isobestic point 255 nm for both drugs. The retesion factor of Cefpodoxime Proxetil and Ofloxacin were found to be 0.63 and 0.25, respectively. The reliability of the method was assessed by evaluation of linearity range (500-3000 ng/spot for both Cefpodoxime proxetil and ofloxacin respectively. Accuracy (99.56 % for Cefpodoxime Proxetil and 99.33% for Ofloxacin), and specificity, in compliance with ICH guidelines. [ABSTRACT FROM AUTHOR]

Glaucoma is one of the most common ophthalmic conditions encountered in primary and secondary care. The glaucoma is a group of progressive optic neuropathies characterized by degeneration of retinal ganglion cells and resulting changes in the optic nerve head. It is usually associated with an increase in intraocular pressure (IOP) above the normal value--usually estimated at 21 mm Hg. Loss of ganglion cells is related to the level of intraocular pressure, but other factors may also play a role. Reduction of intraocular pressure is the only proven method to treat the disease. Although treatment is usually initiated with ocular hypotensive drops, laser trabeculoplasty and surgery may also be used to slow disease progression. [ABSTRACT FROM AUTHOR]