1. Effects of single-dose neuropeptide Y on levels of hippocampal BDNF, MDA, GSH, and NO in a rat model of pentylenetetrazole-induced epileptic seizure
- Author
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Berrin Oztas, Mert Musul, Sevinc Kuskay, Deniz Sahin, and Hale Maral Kir
- Subjects
Male ,medicine.medical_specialty ,Convulsants ,Nitric Oxide ,medicine.disease_cause ,Hippocampus ,behavioral disciplines and activities ,Nitric oxide ,chemistry.chemical_compound ,epileptic seizure ,Malondialdehyde ,Internal medicine ,medicine ,oxidative stress ,Animals ,Hippocampus (mythology) ,Neuropeptide Y ,Rats, Wistar ,Brain-derived neurotrophic factor ,lcsh:R5-920 ,Epilepsy ,business.industry ,Brain-Derived Neurotrophic Factor ,General Medicine ,Glutathione ,Neuropeptide Y receptor ,nitrosative stress ,Rats ,nervous system diseases ,Disease Models, Animal ,Endocrinology ,chemistry ,Anesthesia ,Convulsant ,Pentylenetetrazole ,lcsh:Medicine (General) ,business ,Oxidative stress ,Research Article - Abstract
Epilepsy is one of the most common neurological disorders, characterized by recurrent seizures, which may increase the content of reactive oxygen and nitrogen species. Th e objective of this study was to investigate the eff ects of Neuropeptide Y on oxidative and nitrosative balance and brain-derived neurotrophic factor levels induced by pentylenetetrazole (a standard convulsant drug) in the hippocampus of Wistar rats. Th ree groups of seven rats were treated intraperitoneally as follows: group (saline + saline) ml saline, group (salin + Pentylenetetrazole) ml saline min before Pentylenetetrazole; and group (Neuropeptide Y + Pentylenetetrazole) μg/kg Neuropeptide Y min before mg/kg Pentylenetetrazole. After h, the animals were euthanized by decapitation. Hippocampus were isolated to evaluate the malondialdehyde, glutathione, nitric oxide, and brain-derived neurotrophic factor levels in three rat groups. Th e results of this study demonstrated that while intraperitoneally administered neuropeptide Y did not result in a statistically signifi cant diff erence in BDNF levels, its administration caused a statistically signifi cant decrease in malondialdehyde and nitric oxide levels and an increase in glutathione levels in rats with pentylenetetrazole-induced epileptic seizure. Neuropeptide Y were able to reduce nitroxidative damage induced by pentylenetetrazole in the hippocampus of Wistar rats.
- Published
- 2013