1. Myelodysplastic syndromes (MDS): prognostic factors and scoring systems
- Author
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Lígia Niero-Melo, Gisele Wally Braga, Elizabeth Xisto Souto, Maria Regina Regis Silva, Maria de Lourdes Lopes Ferrari Chauffaile, José Kerbauy, José Eduardo Cajado Moncau, Universidade Federal de São Paulo, and Universidade Estadual Paulista (Unesp)
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,Survival ,Myelodysplastic syndromes ,lcsh:Medicine ,Severity of Illness Index ,Actuarial Analysis ,Internal medicine ,Severity of illness ,medicine ,Humans ,Survival analysis ,Liver size ,Aged ,Retrospective Studies ,Aged, 80 and over ,Univariate analysis ,business.industry ,lcsh:R ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Survival Analysis ,Myelodysplastic Syndromes ,Multivariate Analysis ,Female ,business - Abstract
Made available in DSpace on 2021-07-14T10:28:24Z (GMT). No. of bitstreams: 0 Previous issue date: 1997-10. Added 1 bitstream(s) on 2021-07-14T11:31:09Z : No. of bitstreams: 1 S1516-31801997000500005.pdf: 1282509 bytes, checksum: ce9f96a3d352cb8355d061cb7571b0d9 (MD5) OBJETIVO: Avaliar utilidades dos sistemas de escore de Cassano e Sanz e propor outro. DESENHO: Serie de Casos. LOCAL: Hospitais universitários: EPM-UNIFESP e Faculdade de Medicina de Botucatu. PARTICIPANTES: 59 pacientes diagnosticados entre 1979 e 1992. INTERVENÇÃO: Avaliação de parâmetros clínico-laboratoriais. MENSURAÇÃO: Comparação estatística, análise uni e multivariada e curva de sobrevida atuarial. RESULTADOS: O sistema de Cassano dividiu os pacientes em alto e baixo risco (p=0.0966) enquanto o de Sanz em alto, intermediário e baixo risco (p=0.0108). A análise univariada demonstrou que hemoglobina, contagem de GB, relação EM, aumento do fígado e % de blastos na medula (MO) eram estatisticamente significantes. A regressão multivariada demonstrou como sendo significantes a % de blastos da MO (p=0.004) e os níveis de Hb (p=0.050). O nosso sistema, considerando os parâmetros da análise univariada, dividiu os pacientes em alto, intermediário e baixo risco (p=0.0038). CONCLUSÕES: O sistema de Sanz foi mais prático que o de Cassano enquanto o nosso, demonstrou valor preditivo de sobrevida e uso fácil na prática clínica. OBJECTIVE: To evaluate the score systems of Cassano and Sanz and suggest a new one. DESIGN: Case series. LOCATION: Teaching hospitals: EPM UNIFESP and Faculdade de Medicina de Botucatu. PARTICIPANTS: 59 patients diagnosed from 1979 to 1992. INTERVENTION: Evaluation of clinical-laboratorial data. MEASUREMENT: Statistical comparison, uni and multivariate analysis and actuarial survival curves. RESULTS: Cassano's system divided the patients into high and low risk (p=0.0966) while, Sanz's gave high, intermediate and low risk (p=0.0108). The univariate analysis showed hemoglobin, WBC count, E/M ratio, liver size and blast percentage in BM as statistically significant. The multivariate analysis showed blast percentage in BM (p=0.004) and Hb (p=0.050) as significant. Our system, considering the multivariate analysis data, divided the patients into high, intermediate and low risk (p=0.0038). CONCLUSIONS: Sanz's system was more functional than Cassano's, while ours showed predictive survival value and ease of use in clinical practice. Universidade Federal de São Paulo, Escola Paulista de Medicina Universidade Estadual Paulista Universidade Estadual Paulista
- Published
- 1997