1. [Cytogenetic analysis of material from spontaneous abortion].
- Author
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Rolnik DL, Carvalho MH, Catelani AL, Pinto AP, Lira JB, Kusagari NK, Belline P, and Chauffaille Mde L
- Subjects
- Adolescent, Adult, Chromosomes, Human, Pair 16, Female, Humans, Middle Aged, Mosaicism statistics & numerical data, Pregnancy, Retrospective Studies, Trisomy, Young Adult, Abortion, Spontaneous genetics, Chromosome Aberrations statistics & numerical data, Cytogenetic Analysis
- Abstract
Objective: To describe chromosomal abnormalities in spontaneous abortion material., Methods: A retrospective compilation of karyotype analysis of slides stained with Band G was carried out by optical microscopy with materials of 428 abortion products referred for study., Results: There were 145 normal results (33.9%) and 237 abnormal results (55.4%). In 46 samples there was no cell growth (10.7%). Numerical abnormalities were the most frequent, especially trisomy 16 (41 cases), triplodia (27 cases), monosomy X (26 cases), tetraploidy (13 cases) and trisomy 15 (13 cases)., Conclusion: Cytogenetic alterations are an important cause of pregnancy loss and their detection helps the genetic counseling to the couple. Trisomy 16 is the most often found change.
- Published
- 2010
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