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2. Are enterococcal bloodstream infections an independent risk factor for a poorer 5-year survival or just a marker for severity of illness?-The Munich multicentric enterococci cohort.

Author

Rothe K, Bachfischer T, Karapetyan S, Hapfelmeier A, Wurst M, Gleich S, Dichtl K, Schmid RM, Triebelhorn J, Wagner L, Erber J, Voit F, Burgkart R, Obermeier A, Seibold U, Busch DH, Rämer PC, Spinner CD, and Schneider J

Subjects
Humans, Enterococcus, Prospective Studies, Escherichia coli, Risk Factors, Patient Acuity, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Bacteremia epidemiology, Gram-Positive Bacterial Infections diagnosis, Gram-Positive Bacterial Infections epidemiology, Sepsis, Escherichia coli Infections epidemiology
Abstract

Importance: The present study provides a substantial contribution to literature, showing that patients with enterococcal bloodstream infections (BSI) have a lower survival rate than those with Escherichia coli ( E. coli ) bloodstream infections after adjusting for 17 limiting prognostic factors and excluding patients with a limited life expectancy [metastatic tumor disease, Charlson Comorbidity Index (CCI) (greater than or equal to) 5]. This difference in the 5-year long-term survival was mainly driven by Enterococcus faecium (ECFM) bloodstream infections, with vancomycin resistance not being a significant contributing factor. Our findings imply that E. faecium bloodstream infections seem to be an independent risk factor for poor long-term outcomes. As such, future research should confirm this relationship and prioritize investigating its causality through prospective studies., Competing Interests: The authors declare no conflict of interest.

Published
2023
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