1. Targeted metagenomic assessment reflects critical colonization in battlefield injuries.
- Author
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Kok CR, Mulakken N, Thissen JB, Grey SF, Avila-Herrera A, Upadhyay MM, Lisboa FA, Mabery S, Elster EA, Schobel SA, and Be NA
- Subjects
- Humans, Wound Infection diagnosis, Wound Infection microbiology, Metagenome, War-Related Injuries diagnosis, War-Related Injuries microbiology
- Abstract
Importance: Microbial contamination in combat wounds can lead to opportunistic infections and adverse outcomes. However, current microbiological detection has a limited ability to capture microbial functional genes. This work describes the application of targeted metagenomic sequencing to profile wound bioburden and capture relevant wound-associated signatures for clinical utility. Ultimately, the ability to detect such signatures will help guide clinical decisions regarding wound care and management and aid in the prediction of wound outcomes., Competing Interests: The authors declare no conflict of interest.
- Published
- 2023
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