1. First Insight into the Genome Sequences of Two Linezolid-Resistant Nocardia farcinica Strains Isolated from Patients with Cystic Fibrosis
- Author
-
María J. Medina-Pascual, Ángel Zaballos, Noelia Garrido, José Manuel Azcona-Gutiérrez, Begoña Vilar, Sylvia Valdezate, Sara Monzón, Isabel Cuesta, and Instituto de Salud Carlos III
- Subjects
0301 basic medicine ,Mutation ,biology ,Sulfamethoxazole ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,medicine.disease ,medicine.disease_cause ,bacterial infections and mycoses ,Cystic fibrosis ,Genome ,Trimethoprim ,Microbiology ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,chemistry ,23S ribosomal RNA ,Linezolid ,Genetics ,medicine ,bacteria ,Molecular Biology ,Nocardia farcinica ,medicine.drug - Abstract
The draft genome sequences of two Nocardia farcinica strains isolated from two patients with cystic fibrosis (CF), resistant to trimethoprim/sulfamethoxazole and linezolid, are reported here. The estimated genome sizes were 5.8 Mb with a 70.63% G+C content. Transposases from Tn916 were detected, but not 23S rRNA mutation (G2576T) related to linezolid resistance. We are grateful to G. Carrasco, P. Jimenez, and J. A. Saéz-Nieto for their help in different stages of genome sequencing, and Adrian Burton for editing and language assistance (Physical Evidence Scientific Translations; http://www.physicalevidence.es). This work was funded by project MPY1278/15 of the Instituto de Salud Carlos III. Sí
- Published
- 2017