1. Clinical utility of CA-125 in the management of uterine carcinosarcoma
- Author
-
Munetaka Takekuma, Marian S. Johnson, Koji Matsuo, Keita Iwasaki, Tadayoshi Nagano, Frederick R. Ueland, Dwight D. Im, Satoshi Takeuchi, Joseph L. Kelley, Tsukasa Baba, Shinya Satoh, Mayu Yunokawa, Merieme Klobocista, Masato Nishimura, Sosuke Adachi, Stephen H. Bush, Malcolm S. Ross, Hiroko Machida, Yutaka Ueda, Takuhei Yokoyama, Yuji Ikeda, Kohei Omatsu, Masako Shida, Tadao Takano, Shiori Yanai, Erin A. Blake, Tanja Pejovic, Lynda D. Roman, Mian M.K. Shahzad, Takahito Miyake, and Kosei Hasegawa
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Ca 125 antigen ,Black People ,White People ,03 medical and health sciences ,0302 clinical medicine ,Text mining ,Carcinosarcoma ,Correspondence ,Humans ,Medicine ,Uterine carcinosarcoma ,Uterine Neoplasm ,Aged ,Retrospective Studies ,business.industry ,Racial Groups ,Age Factors ,Obstetrics and Gynecology ,General Medicine ,Middle Aged ,medicine.disease ,National Cancer Institute (U.S.) ,United States ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Uterine Neoplasms ,Female ,business ,SEER Program - Abstract
Uterine carcinosarcoma (UCS) is a rare type of high-grade endometrial cancer (EC) that has been understudied with population-based statistics due to its rarity. This study examined temporal trends in the proportion of UCS among women with EC.This is a retrospective observational study examining The Surveillance, Epidemiology, and End Results program between 1973-2013. Primary EC cases were eligible for analysis, and a time-specific proportion of UCS was examined during the study period.UCS was seen in 11,000 (4.7%) women among 235,849 primary EC cases. Mean age at UCS diagnosis increased from 65.9 to 71.7 years between 1973-1989 and then decreased from 71.7 to 67.0 years between 1989-2013 (both, p0.001). Proportion of Black women significantly increased during the study period (11.9%-20.0%, p0.001), whereas the proportion of White women decreased from 86.0% to 60.5% between 1987-2013 (p0.001). There was a significant increase in the proportion of UCS among primary EC from 1.7% to 5.6% between 1973-2013 (p0.001). Among type II ECs (n=76,118), the proportion of UCS also increased significantly from 6.0% to 17.5% between 1973-2013 (p0.001). An increasing proportion of UCS was seen in both young and older women but the magnitude of interval increase was larger in the older age group between 1973-2013 (60 years, from 1.3% to 3.3%. p0.001; and ≥60 years, from 2.6% to 7.0%, p0.001).Our study demonstrated that the proportion of UCS has significantly increased among EC, accounting for more than 5% in recent years.
- Published
- 2018