Search

Pancreatic cancer is diagnosed infrequently in cats, with pancreatitis and adenomas as differential diagnoses. A 3-year-old cat, mixed breed, was treated with hyporexia, prostration and epigastric pain. The abdominal ultrasound showed a solid formation and irregular contours in the right hypogastric region, vascularity on Doppler, without separation plane with duodenum and abdominal effusion. Computed tomography was performed, which confirmed the presence of a 9-cm tumor area caudal to the caudate process of the hepatic lobe, in close contact with the splenic and portal veins. The patient underwent partial pancreatectomy for morphological diagnosis and relief. The extracted material was fixed in formaldehyde and the initial morphological diagnosis was solid standard undifferentiated carcinoma. Subsequently, immunohistochemistry was performed to define histogenesis, being positive for markers AE1AE3; CDX2, CK8 ̸18, CK20 and Ki67 for prognosis, which favored solid acinar pancreatic carcinoma, with 80% of cells in cell division. Treatment was started with adjuvant chemotherapy, alternating doxorubicin and carboplatin every 28 days. After 4 months of treatment, the patient gained weight, remained active, with normorexia, but there was tumor recurrence with peritoneal carcinomatosis. It was associated with metronomic chemotherapy with daily prednisone and cyclophosphamide every other day. The low number of diagnoses and scarcity of information in the literature limit treatment options and therapeutic possibilities. Acinar pancreatic adenocarcinoma is a rare occurrence among cats, with a high chance of metastasis and survival from days to a few months after diagnosis. The established treatment was well tolerated by the patient and seems to be an option in the control of this type of disease. [ABSTRACT FROM AUTHOR]

Hemangiosarcoma is a cancer with high power of malignancy and metastasis, originating in endothelial cells of blood vessels, it is often found in the spleen, skin and rarely in the nasal cavity of dogs. A dog, SRD, 13 years old, was treated with hemorrhagic nasal discharge in the left nostril and increase in volume dorsal to the nose that extended to the frontal sinus, with exophthalmos of the left eyeball, which had been installed acutely. On the skull X-ray in the lateral oblique and dorsal-ventral projections, bone lysis of the nasal, frontal and orbital sinuses was observed. After collecting material for cytopathology, the presumptive diagnosis was osteosarcoma. In order to plan the surgical act, a computed tomography scan of the skull was performed, which showed formation in the left nasal cavity, with expansion up to the orbital bone, without involvement of regional lymph nodes. In order to assess hemostasis and possibilities of thromboembolism in the postoperative period, a thromboelastogram was performed and the patient had possibilities of having a thrombus. He was successfully operated on, removing most of the tumor mass and using electrochemotherapy in the surgical bed. The histopathological diagnosis was grade 2 poorly differentiated hemangiosarcoma. The patient received treatment with anticoagulants in the following days, had a satisfactory recovery and adjuvant chemotherapy with doxorubicin was started 1 month after surgery, however, he presented compatible diffuse bleeding. with ICD and died. Hemangiosarcomas are rare in the nasal cavity of dogs and seem to have a worse behavior in this region when compared to the spleen and skin, including the possibility of paraneoplastic syndrome. The thrombolestogram has been shown to be an important test for evaluating the hemostatic balance in the control of neoplastic diseases. [ABSTRACT FROM AUTHOR]

A Golden Retriever canine patient was seen at a private veterinary clinic, with an extensive nodular skin formation in the right ventrolateral region, with a one-year evolution. The lesion had a soft consistency, with the presence of solid and straight nodules inside, in the middle of liquid. The material was collected through fine-needle aspiration puncture and the cytopathological result was inconclusive for neoplasm. No noteworthy changes were observed on abdominal ultrasound. After performing a computed tomography scan of the skin formation, the images were compatible with an abscess or hematoma, with areas of mineralization. The animal was submitted to surgical procedure for excisional biopsy, with the morphological diagnosis of sterile nodular panniculitis with steatonecrosis, process of cell death of adipocytes. The surgical procedure was considered curative, because even after one year, there was no recurrence in the site or formation of other skin nodules. This pathology is uncommon in dogs, especially the Golden Retrevier breed and in the abdominal region of the subcutaneous tissue. Although some hypotheses are correlated, the cause of this pathology remains idiopathic. [ABSTRACT FROM AUTHOR]

A 9-year-old canine patient, SRD, was referred to the oncology service after removal of a dermal hemangiosarcoma in the abdomen. After searching for metastasis, he found through chest radiography the presence of a circular, homogeneous 4 cm formation in the right hemithorax in topography of the pulmonary accessory lobe. Complementary cardiological and imaging exams, such as echocardiography and later contrast-enhanced computed tomography, were performed, which confirmed the presence of aneurysm in the caudal vena cava. The patient was asymptomatic, therefore, having been considered a finding in clinical staging. Aneurysm is a vascular dilation, a rare pathology in dogs, mainly in the caudal vena cava and its causes are still uncertain, with genetics as the most plausible and probable. Although hemangiosarcoma is not the main cause for the development of the aneurysm, it served as a trigger for this finding. This pathology still remains rare in veterinary medicine, even though animals are used as the main study models for the treatment of aneurysms in humans. [ABSTRACT FROM AUTHOR]