Search

Objective: Describe the efficacy and safety of tenofovir., Methods: Observational, descriptive study. Data were analyzed for the intention-to-treat sample. The primary efficacy end-point included the proportion of patients with HIV-1 RNA level of 50 copies/ml or less. Secondary efficacy end points was the increase of the CD4 cell count at week 48. The primary safety end-point was the number of patients with abnormalities (clinical adverse events and laboratory toxicities). The causality of the adverse effects was measured by the Naranjo algorithm., Results: 154 subjects were enrolled; 12 were excluded from all analyses. Efficacy end points: Plasma HIV-1 RNA response: -1.29 +/- 0.97 log10 copies/ml; Patients with HIV-1 RNA levels of 50 copies/ml or less: 28.16%; CD4 cell count response: 40.27 +/- 141.50 cel/mm3. Safety profile was similar to showed at prescribing information, 3 Fanconi Syndrome were detected., Conclusion: Tenofovir supposes an antiretroviral of high effectiveness in our hospital, with an optimum safety profile.

Background: Study about the admissions appropriateness in the Internal Medicine ward of Hospital Juan Ramón Jiménez., Material and Methods: Retrospective review of the admissions in the first three months of 1997 not coming from any other ward. Two physicians not responsible of the admission evaluated separately the medical records by using the Appropriateness Evaluation Protocol. 201 patients were selected randomly from the 518 admissions which accomplished the criteria formerly exposed., Results: 13.4% of the admissions did not fulfill any criteria of the Appropriateness Evaluation Protocol. The most frequent inadequate admission cause was for diagnostic purposes (66%). No significative difference was found in the percentage of inappropriate admissions with respect to age, gender, days of stay and number of previous admissions., Conclusions: The percentage of inappropriate admissions was slightly lower than that of similar studies carried out in similar conditions, probably because of the possibility of moving the patient to lower levels of care units according their needs.