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1. Sprue-like enteropathy associated with olmesartan in a patient with villous atrophy, HLA-DQ2 genotype and antinuclear antibodies.

Author

Machado I, Reolid M, Martínez de Juan F, Martínez Lapiedra C, and Maia de Alcántara F

Subjects
Aged, Atrophy, Gastrointestinal Diseases genetics, Genotype, Humans, Male, Antibodies, Antinuclear immunology, Anticholesteremic Agents adverse effects, Celiac Disease diagnostic imaging, Gastrointestinal Diseases chemically induced, Gastrointestinal Diseases diagnostic imaging, HLA-DQ Antigens genetics, Imidazoles adverse effects, Tetrazoles adverse effects
Abstract

We describe a new case of enteropathy with villous atrophy in a patient suffering from arterial hypertension treated with olmesartan. The molecular and serological studies showed anti-nuclear antibodies (ANA) and haplotype HLA-DQ2 positive, as well as negative results for anti-transglutaminase, anti-endomysium and anti-enterocytes antibodies. A duodenal villous atrophy was suspected by upper gastrointestinal endoscopy, which was confirmed by histopathology. The morphological picture was suggestive of sprue-like enteropathy with severe lymphoid infiltration and predominant T lymphoid cells.

Published
2016

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