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Abstract Background: Silver nanoparticles are capable of inducing toxicity in living organisms. Silver nanoparticles can induce some effect in the liver. Thus silver nanoparticles, due to their wide spread effects, can also affect on hepatic, hematological, and oxidative stress factors. Ginger because of its powerful antioxidantal compounds can influence the toxicity effects of silver nanoparticles in different parts of the body. The aim of this study was to investigate the protective effect of hydroalchoholic extract of ginger on cytotoxic silver nanoparticles on enzymes, hematological parameters, blood oxidative stress markers, and hepatic apoptosis in Balb-c mice. Materials and Methods: In this study, 48 rats of Balb-c race Syrians were selected and devided into 4 groups, each consisting of 12. They were treated for a period of 35 days; the first group (control) received distilled water, the second group received nano silver, the third group received ginger extract, and the fourth group received both nanosilver and ginger extract at the same time. Bleeding was done to measure hematological factors, liver enzymes, and oxidative stress; then liver tissue was removed for evaluation of apoptosis. Data were compared using SPSS software and one-way ANOVA. Results: Enzymes AST , ALT , ALP, GGT and LDH as liver factors showed significant differences in the groups of the study. Hematological factors including of WBC , RBC , Hb , HCT , MCV , MCH , Plt , Lymphocyte and Monocyte showed significant differences in all the groups. Of oxidative stress factors , only GPX showed significant difference between groups, while no significant difference was observed in other oxidative stress parameters in the blood. Changes in apoptosis showed significant differences in all groups of the study. Conclusion Based on the findings the study, silver nanoparticles with their side effects in different parts of the body can induce changes in various factors and enzymes. Ginger can compensate ,and modify to some extent these side effects. Such effectiveness of ginger can probably be due to its special ingredients.