1. A Real-world Multicenter Prospective Study of Everolimus in Pancreatic Neuroendocrine Tumors: The ‘PROTOR’ Study
- Author
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Gregory, Kaltsas, Charalambos, Andreadis, Paraskevas, Kosmidis, Dimitrios, Mavroudis, Kalliopi, Pazaitou-Panayiotou, Michail, Vaslamatzis, and Ilias, Athanasiadis
- Subjects
Pancreatic Neoplasms ,Neuroendocrine Tumors ,Cancer Research ,Oncology ,Humans ,Everolimus ,Kaplan-Meier Estimate ,Prospective Studies ,General Medicine ,Middle Aged - Abstract
Pancreatic neuroendocrine tumors (panNETs) are rare neoplasms with challenging disease management. We aimed to evaluate the progression-free survival (PFS) and overall response rate (ORR) in chemotherapy-naïve patients with unresectable or metastatic Grade (G) 1-2 panNETs treated with everolimus in the routine care in Greece.This was a multicenter, prospective, observational study. Eligible patients were recently (≤4 weeks) initiated on treatment with everolimus and were followed for up to 48 months.Nineteen eligible patients (mean age 55.1 years) were enrolled. All patients had metastatic disease and 84.2% had G2 panNET. Everolimus was initiated in combination with somatostatin analogues in 84.2% of the patients. The mean everolimus treatment duration was 21.5 months. The median Kaplan-Meier-estimated PFS was 20.4 months (95% confidence interval=14.1-41.5). The ORR was 27.8%. The rate of everolimus-related adverse events was 84.2% (Grade ≥3: 31.6%).Everolimus displayed clinical benefit and a predictable safety profile in pancreatic neuroendocrine tumors.
- Published
- 2022