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Objective: Obstructive sleep apnea syndrome (OSAS) is associated with increased cardiovascular morbidity and mortality. Red cell distribution width (RDW), a measure of the variability in size of circulating erytrocytes, has been reported to be a risk marker of morbidity and mortality for cardiovascular disease. Therefore, we have investigated the possible association between OSAS and RDW. Material and Methods: We selected 30 mild, 32 moderate and 31 severe OSAS patients and 31 healthy control subjects matched for age, sex, and body mass index. RDW was measured by using an automated blood cell counter. Results: The RDW values were significantly higher in patients with severe OSAS than in the control group (14.6±2.1 vs.13.2±2.4 %; p=0,03). There were no significant differences between controls and patients with mild and moderate OSAS (13.2±2.4 vs. 13.4±0.6 %; p=0,98; 13.2±2.4 vs. 14.0±2.4 %; p = 0.43) and between patients with mild, moderate and severe OSAS (13.4±0.6 vs. 14.0±2.4 vs. 14.6±2.1 %; p=0,67 for comparison of mild and moderate OSAS, p=0.08 for comparison of mild and severe OSAS, p=0.56 for comparison of moderate and severe OSAS) in respect to RDW. Additionally, significant correlation of RDW with parameters of sleep was noted. RDW was correlated with apnea-hypopnea index (r=0.264, p=0.01) and minimal oxygen saturation (r=-0,284, p=0.006). Conclusions: RDW is a widely available diagnostic marker, routinely performed hemogram. In our study, we found that RDW was higher in the patients with OSAS compared with the control group. These results show that RDW is an important marker in terms of identifying the risk of atherosclerosis in patients with OSAS at an early stage. [ABSTRACT FROM AUTHOR]

Aim: Obstructive sleep apnea syndrome (OSAS) is common in society, and hypothyroidism is a disease that can be seen along with rates ranging from 1.2 to 11%. Symptomatology spectrum of OSAS is very wide. These symptoms suggest OSAS but these symptoms are not definitive diagnostic feature. Patients with OSAS have symptoms such as throughout the day drowsiness, obesity, snoring, apathy and lethargy, that can be seen in all of them are faced with hypothyroidism. Regarded among the etiological causes in endocrine disorders, reduction of thyroid hormones can be easily detected. Measurement of serum levels of thyroid hormone is inexpensive and it is guidance for treatment planning. We investigate thyroid hormone levels in patients who were diagnosed as OSAS with polysomnography (PSG) and determine the prevalence of hypothyroidism in patients with OSAS. Material and Method: Ninety-three patients with complaints of snoring who were diagnosed as OSAS with PSG were examined in the study between March 2009-November 2010. Thyroid function tests were performed in these patients. Results: According to the severity, 30 patients were in mild, 32 patients were in moderate and 31 patients were in severe OSAS group. Hypothyroidism was detected in 5 of those 93 OSAS patients (5,37%). Two of these patients had clinical hypothyroidism and three of these patients had subclinical hypothyroidism. Conclusion: In our study, the prevalence of hypothyroidism and OSAS was found compatible with the literature. Reduction in symptoms and apnea hypopnea index with thyroid hormone therapy in OSAS patients with hypothyroidism is considering and hypothyroidism screening tests should be made with the suspicion of OSAS. [ABSTRACT FROM AUTHOR]