1. Post‐transfusion hepatitis revisited
- Author
-
Sally Thomas, Anthony J. Keller, Kenneth G Kenrick, Susan L Ismay, Gordon T Archer, Yvonne E. Cossart, Annette Fellows, and Brenton R Wylie
- Subjects
medicine.medical_specialty ,Hepatitis C virus ,Blood Donors ,Hepacivirus ,medicine.disease_cause ,Internal medicine ,medicine ,Humans ,Hepatitis Antibodies ,Prospective Studies ,Cardiac Surgical Procedures ,Risk factor ,Retrospective Studies ,Hepatitis ,biology ,business.industry ,Transfusion Reaction ,Alanine Transaminase ,Western Australia ,General Medicine ,Hepatitis C ,Hepatitis C Antibodies ,Hepatitis B ,medicine.disease ,Immunology ,biology.protein ,Viral disease ,New South Wales ,Antibody ,business ,Viral hepatitis - Abstract
OBJECTIVE To evaluate the risk of post-transfusion and postoperative non-A non-B hepatitis in Australia immediately before the introduction of screening for hepatitis C. DESIGN Retrospective testing of blood samples from a prospective study of cardiac surgery patients. Samples were taken from transfusion recipients and non-transfused controls at regular intervals for 12 months after surgery during 1987-1989. For all donor, recipient and control samples, alanine aminotransferase (ALT) levels were measured and tests for antibody to hepatitis B (anti-HBc, anti-HBs) and, when available, to hepatitis C (anti-HCV) were performed. SETTING Cardiac surgery units. PARTICIPANTS Participants were included if they lived in the metropolitan area, and had not had a transfusion in the past year. MAIN OUTCOME MEASURES Post-transfusion hepatitis (two consecutive samples showing raised ALT levels, > 90 IU/L with no other known cause); hepatitis C infection and carriage (antibody to hepatitis C). RESULTS Post-transfusion hepatitis occurred in 1.1% of 736 recipients of blood not screened for hepatitis C (i.e., two cases per 1000 unscreened units given). No hepatitis occurred in 514 controls. Seven of the eight patients with post-transfusion hepatitis seroconverted to hepatitis C virus infection. Seven of the 26 anti-HCV-positive donations transmitted hepatitis C, six of these were positive by recombinant immunoblot assay (RIBA) (one by second generation testing only) and one was RIBA indeterminate. Nineteen were RIBA non-reactive; one transmitted hepatitis but the recipient did not develop anti-HCV, although hepatitis C RNA was detected in the donation. Serum ALT was raised in four of the six infective donations. CONCLUSIONS Hepatitis C virus infection accounted for almost all cases of non-A non-B post-transfusion hepatitis. First generation anti-HCV tests detected about 85% of infective donations. Surrogate testing of donations by ALT or anti-HBc offers no additional advantage.
- Published
- 1995