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Your search keyword '"de‐Torres, Juan P."' showing total 20 results
Start Over Author "de‐Torres, Juan P." Publisher american thoracic society
20 results on '"de‐Torres, Juan P."'

1. Online Data Supplement: Dynamic Ventilatory Reserve During Incremental Exercise: Reference Values and Clinical Validation in Chronic Obstructive Pulmonary Disease.

Author

Berton, Danilo C., Plachi, Franciele, James, Matthew D., Vincent, Sandra G., Smyth, Reginald M., Domnik, Nicolle J., de-Torres, Juan P., Nery, Luiz E., O'Donnell, Denis E., and Neder, J. Alberto

Subjects
REFERENCE values, CHRONIC obstructive pulmonary disease, VENTILATION, OXYGEN consumption, FORCED expiratory volume
Published
2023
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2. Dynamic Ventilatory Reserve During Incremental Exercise: Reference Values and Clinical Validation in Chronic Obstructive Pulmonary Disease.

Author

Berton, Danilo C., Plachi, Franciele, James, Matthew D., Vincent, Sandra G., Smyth, Reginald M., Domnik, Nicolle J., Phillips, Devin B., de-Torres, Juan P., Nery, Luiz E., O'Donnell, Denis E., and Neder, J. Alberto

Subjects
EXERCISE tolerance, VENTILATION, CHRONIC obstructive pulmonary disease, REFERENCE values, OBSTRUCTIVE lung diseases, EXERCISE tests
Abstract

Rationale: Ventilatory demand-capacity imbalance, as inferred based on a low ventilatory reserve, is currently assessed only at peak cardiopulmonary exercise testing (CPET). Peak ventilatory reserve, however, is poorly sensitive to the submaximal, dynamic mechanical ventilatory abnormalities that are key to dyspnea genesis and exercise intolerance. Objectives: After establishing sex- and age-corrected norms for dynamic ventilatory reserve at progressively higher work rates, we compared peak and dynamic ventilatory reserve for their ability to expose increased exertional dyspnea and poor exercise tolerance in mild to very severe chronic obstructive pulmonary disease (COPD). Methods: We analyzed resting functional and incremental CPET data from 275 controls (130 men, aged 19-85 yr) and 359 Global Initiative for Chronic Obstructive Lung Disease patients with stage 1-4 obstruction (203 men) who were prospectively recruited for previous ethically approved studies in three research centers. In addition to peak and dynamic ventilatory reserve (12[ventilation / estimated maximal voluntary ventilation]3100), operating lung volumes and dyspnea scores (0-10 on the Borg scale) were obtained. Results: Dynamic ventilatory reserve was asymmetrically distributed in controls; thus, we calculated its centile distribution at every 20 W. The lower limit of normal (lower than the fifth centile) was consistently lower in women and older subjects. Peak and dynamic ventilatory reserve disagreed significantly in indicating an abnormally low test result in patients: whereas approximately 50% of those with a normal peak ventilatory reserve showed a reduced dynamic ventilatory reserve, the opposite was found in approximately 15% (P,0.001). Irrespective of peak ventilatory reserve and COPD severity, patients who had a dynamic ventilatory reserve below the lower limit of normal at an isowork rate of 40W had greater ventilatory requirements, prompting earlier attainment of critically low inspiratory reserve. Consequently, they reported higher dyspnea scores, showing poorer exercise tolerance compared with those with preserved dynamic ventilatory reserve. Conversely, patients with preserved dynamic ventilatory reserve but reduced peak ventilatory reserve reported the lowest dyspnea scores, showing the best exercise tolerance. Conclusions: Reduced submaximal dynamic ventilatory reserve, even in the setting of preserved peak ventilatory reserve, is a powerful predictor of exertional dyspnea and exercise intolerance in COPD. This new parameter of ventilatory demand-capacity mismatch may enhance the yield of clinical CPET in the investigation of activity-related breathlessness in individual patients with COPD and other prevalent cardiopulmonary diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Impaired Ventilatory Efficiency, Dyspnea, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease: Results from the CanCOLD Study

Author

Phillips, Devin B., primary, Elbehairy, Amany F., additional, James, Matthew D., additional, Vincent, Sandra G., additional, Milne, Kathryn M., additional, de-Torres, Juan P., additional, Neder, J. Alberto, additional, Kirby, Miranda, additional, Jensen, Dennis, additional, Stickland, Michael K., additional, Guenette, Jordan A., additional, Smith, Benjamin M., additional, Aaron, Shawn D., additional, Tan, Wan C., additional, Bourbeau, Jean, additional, O’Donnell, Denis E., additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hogg, James C., additional, Hamid, Qutayba, additional, Doiron, Dany, additional, Mancino, Palmina, additional, Li, Pei-Zhi, additional, Song, Zhi, additional, Fortier, Yvan, additional, Chapman, Kenneth, additional, McClean, Patricia, additional, Duke, Jane, additional, Gershon, Andrea S., additional, Toh, Teresa, additional, Sadatsafavi, Mohsen, additional, Sin, Don, additional, Fitzgerald, J. Mark, additional, Road, Jeremy, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Cheng, Michael, additional, Fung, Cynthia, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Choi, Rena, additional, Comeau, Joe, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Walker, Brandie, additional, Dumonceaux, Curtis, additional, Hernandez, Paul, additional, Fulton, Scott, additional, Vandemheen, Kathy, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Maltais, Francois, additional, Brouillard, Cynthia, additional, Marciniuk, Darcy, additional, Clemens, Ron, additional, and Baran, Janet, additional

Published
2022
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4. Lung Cancer Risk among Patients with Asthma–Chronic Obstructive Pulmonary Disease Overlap

Author

Charokopos, Antonios, primary, Braman, Sidney S., additional, Brown, Stacey A. Whittaker, additional, Mhango, Grace, additional, de-Torres, Juan P., additional, Zulueta, Javier J., additional, Sharma, Sunita, additional, Holguin, Fernando, additional, Sigel, Keith M., additional, Powell, Charles A., additional, Federman, Alex D., additional, and Wisnivesky, Juan P., additional

Published
2021
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5. Exercise Tolerance according to the Definition of Airflow Obstruction in Smokers

Author

Neder, J. Alberto, primary, Milne, Kathryn M., additional, Berton, Danilo C., additional, de-Torres, Juan P., additional, Jensen, Dennis, additional, Tan, Wan C., additional, Bourbeau, Jean, additional, O’Donnell, Denis E., additional, Bourbeau, J., additional, Tan, W. C., additional, Jensen, D., additional, Aaron, S. D., additional, Sin, D. D., additional, Chapman, K. R., additional, Maltais, F., additional, Hernandez, P., additional, and Marciniuk, D., additional

Published
2020
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8. Comparison of the 2017 and 2015 Global Initiative for Chronic Obstructive Lung Disease Reports. Impact on Grouping and Outcomes

Author

Cabrera López, Carlos, primary, Casanova Macario, Ciro, additional, Marín Trigo, José María, additional, de-Torres, Juan P., additional, Sicilia Torres, Rebeca, additional, González, Jesús María, additional, Polverino, Francesca, additional, Divo, Miguel, additional, Pinto Plata, Víctor, additional, Zulueta, Javier J., additional, and Celli, Bartolomé, additional

Published
2018
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9. Exercise Tolerance according to the Definition of Airflow Obstruction in Smokers.

Author

Alberto Neder, J., Milne, Kathryn M., Berton, Danilo C., de-Torres, Juan P., Jensen, Dennis, Tan, Wan C., Bourbeau, Jean, O’Donnell, Denis E., Neder, J Alberto, O'Donnell, Denis E, Canadian Respiratory Research Network (CRRN) and the Canadian Cohort of Obstructive Lung Disease (CanCOLD) Collaborative Research Group, and CRRN (Canadian Respiratory Research Network) and the CanCOLD (Canadian Cohort of Obstructive Lung Disease) Collaborative Research Group

Subjects
OBSTRUCTIVE lung diseases, PATIENTS, DIAGNOSIS, RATIO analysis, PERSONS
Abstract

The article describes how forced expiratory volume in one second/forced vital capacity (FEV1/FVC) ratio discordance relates to functional outcomes relevant to subjects' daily functioning. Topics include the fixed FEV1/FVC ratio cutoff can result in over diagnosis of Chronic obstructive pulmonary disease (COPD) in older individuals; and a discordant FEV1/FVC ratio should be individually interpreted in light of clinical data.

Published
2020
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10. Comparison of the 2017 and 2015 Global Initiative for Chronic Obstructive Lung Disease Reports. Impact on Grouping and Outcomes.

Author

López, Carlos Cabrera, Macario, Ciro Casanova, Trigo, José María Marín, de-Torres, Juan P., Torres, Rebeca Sicilia, González, Jesús María, Polverino, Francesca, Divo, Miguel, Plata, Víctor Pinto, Zulueta, Javier J., Celli, Bartolomé, Cabrera López, Carlos, Casanova Macario, Ciro, Marín Trigo, José María, Sicilia Torres, Rebeca, and Pinto Plata, Víctor

Abstract

Rationale: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) document has modified the grading system directing pharmacotherapy, but how this relates to the previous one from 2015 and to comorbidities, hospitalizations, and mortality risk is unknown.Objectives: The aim of this study was to evaluate the changes in the GOLD groups from 2015 to 2017 and to assess the impact on severity, comorbidities, and mortality within each group.Methods: We prospectively enrolled and followed, for a mean of 5 years, 819 patients with chronic obstructive pulmonary disease (84% male) in clinics in Spain and the United States. We determined anthropometrics, lung function (FEV1%), dyspnea score (modified Medical Research Council scale), ambulatory and hospital exacerbations, and the body mass index, obstruction, dyspnea, and exercise capacity (BODE) and Charlson indexes. We classified patients by the 2015 and 2017 GOLD ABCD system, and compared the differential realignment of the same patients. We related the effect of the reclassification in BODE and Charlson distribution as well as chronic obstructive pulmonary disease and all-cause mortality between the two classifications.Measurements and Main Results: Compared with 2015, the 2017 grading decreased by half the proportion of patients in groups C and D (20.5% vs. 11.2% and 24.6% vs. 12.9%; P < 0.001). The distribution of Charlson also changed, whereas group D was higher than B in 2015, they become similar in the 2017 system. In 2017, the BODE index and risk of death were higher in B and D than in A and C. The mortality risk was better predicted by the 2015 than the 2017 system.Conclusions: Compared with 2015, the GOLD ABCD 2017 classification significantly shifts patients from grades C and D to categories A and B. The new grading system equalizes the Charlson comorbidity score in all groups and minimizes the differences in BODE between groups B and D, making the risk of death similar between them. [ABSTRACT FROM AUTHOR]

Published
2018
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12. Improving Selection Criteria for Lung Cancer Screening. The Potential Role of Emphysema

Author

Sanchez-Salcedo, Pablo, primary, Wilson, David O., additional, de-Torres, Juan P., additional, Weissfeld, Joel L., additional, Berto, Juan, additional, Campo, Arantzazu, additional, Alcaide, Ana B., additional, Pueyo, Jesús, additional, Bastarrika, Gorka, additional, Seijo, Luis M., additional, Pajares, Maria J., additional, Pio, Ruben, additional, Montuenga, Luis M., additional, and Zulueta, Javier J., additional

Published
2015
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13. Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease. Development and Validation of the COPD Lung Cancer Screening Score

Author

de-Torres, Juan P., primary, Wilson, David O., additional, Sanchez-Salcedo, Pablo, additional, Weissfeld, Joel L., additional, Berto, Juan, additional, Campo, Arantzazu, additional, Alcaide, Ana B., additional, García-Granero, Marta, additional, Celli, Bartolome R., additional, and Zulueta, Javier J., additional

Published
2015
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16. Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease

Author

de Torres, Juan P., primary, Marín, Jose M., additional, Casanova, Ciro, additional, Cote, Claudia, additional, Carrizo, Santiago, additional, Cordoba-Lanus, Elizabeth, additional, Baz-Dávila, Rebeca, additional, Zulueta, Javier J., additional, Aguirre-Jaime, Armando, additional, Saetta, Marina, additional, Cosio, Manuel G., additional, and Celli, Bartolome R., additional

Published
2011
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