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The article focused on understanding the pathophysiological impact of severe intermittent hypoxia in an effort to better understand the negative impact of obstructive sleep apnea. Topics include positive clinical outcomes are impacted by notable heterogeneity in the intermittent hypoxia protocols used, as well as various patient populations; and impact of carbon dioxide when combined with mild intermittent hypoxia warrants consideration when exploring the positive outcomes.

The article informs about the treatment approach for patients mild intermittent hypoxia (MIH) elicits beneficial cardiovascular and autonomic outcomes in males with obstructive sleep apnea (OSA) and concurrent hypertension. Topics include a controlled intermittent hypoxia conditioning program is a safe and effective way to prevent and treat hypertension; and sustained increases in motor neuron, nerve, and muscle activity that contribute to ventilation and maintain upper airway patency.