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Start Over Author "Sato, Hiroe" Publisher american thoracic society
13 results on '"Sato, Hiroe"'

6. The Clara Cell10 Adenine38Guanine Polymorphism and Sarcoidosis Susceptibility in Dutch and Japanese Subjects

Author

Janssen, Rob, primary, Sato, Hiroe, additional, Grutters, Jan C., additional, Ruven, Henk J. T., additional, du Bois, Ron M., additional, Matsuura, Ryosuke, additional, Yamazaki, Masao, additional, Kunimaru, Shigeki, additional, Izumi, Takateru, additional, Welsh, Ken I., additional, Nagai, Sonoko, additional, and van den Bosch, Jules M. M., additional

Published
2004
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7. C-C Chemokine Receptor 2 and Sarcoidosis

Author

Spagnolo, Paolo, primary, Renzoni, Elisabetta A., additional, Wells, Athol U., additional, Sato, Hiroe, additional, Grutters, Jan C., additional, Sestini, Piersante, additional, Abdallah, Atiyeh, additional, Gramiccioni, Enzo, additional, Ruven, Henk J. T., additional, du Bois, Roland M., additional, and Welsh, Kenneth I., additional

Published
2003
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8. Idiopathic Pulmonary Fibrosis

Author

Kaminski, Naftali, primary, Belperio, John A., additional, Bitterman, Peter B., additional, Chen, Li, additional, Chensue, Stephen W., additional, Choi, Augustine M.K., additional, Dacic, Sanja, additional, Dauber, James H., additional, du Bois, Roland M., additional, Enghild, Jan J., additional, Fattman, Cheryl L., additional, Grutters, Jan C., additional, Haegens, Astrid, additional, Hanford, Lana E., additional, Heintz, Nicolas, additional, Henson, Peter M., additional, Hogaboam, Cory, additional, Kagan, Valerian E., additional, Keane, Michael P., additional, Kunkel, Steven L., additional, Land, Susan, additional, Loyd, James E., additional, Lukacs, Nicholas, additional, MacPherson, Maximilian, additional, Manning, Brian, additional, Manning, Nicole, additional, Martinelli, Marcella, additional, Moller, David R., additional, Morse, Danielle, additional, Mossman, Brooke, additional, Noble, Paul W., additional, Nowak, Norma, additional, Oury, Tim D., additional, Pardo, Annie, additional, Perez, Andrew, additional, Petty, Thomas L., additional, Phan, Sem H., additional, Ramos-Nino, Maria E., additional, Ray, Prabir, additional, Rogers, Robert M., additional, Sato, Hiroe, additional, Scapoli, Luca, additional, Schaefer, Lisa M., additional, Selman, Moisés, additional, Stern, Maria, additional, Strollo, Diane C., additional, Tyurin, Vladimir A., additional, Valnickova, Zuzana, additional, Welsh, Kenneth I., additional, Witzmann, Frank A., additional, Yousem, Samuel A., additional, and Strieter, Robert M., additional

Published
2003
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9. HLA-DQB1*0201

Author

Sato, Hiroe, primary, Grutters, Jan C., additional, Pantelidis, Panagiotis, additional, Mizzon, A. Neil, additional, Ahmad, Tariq, additional, van Houte, Arend-Jan, additional, Lammers, Jan-Willem J., additional, van den Bosch, Jules M.M., additional, Welsh, Kenneth I., additional, and du Bois, Roland M., additional

Published
2002
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10. Increased Frequency of the Uncommon Tumor Necrosis Factor − 857T Allele in British and Dutch Patients with Sarcoidosis

Author

Grutters, Jan C., primary, Sato, Hiroe, additional, Pantelidis, Panagiotis, additional, Lagan, Anna L., additional, McGrath, Deirdre S., additional, Lammers, Jan-Willem J., additional, van den Bosch, Jules M. M., additional, Wells, Athol U., additional, du Bois, Roland M., additional, and Welsh, Kenneth I., additional

Published
2002
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11. The importance of sarcoidosis genotype to lung phenotype.

Author

Grutters JC, Sato H, Welsh KI, and du Bois RM

Subjects
Genotype, HLA-DQ Antigens genetics, HLA-DR Antigens genetics, Humans, Phenotype, Sarcoidosis, Pulmonary etiology, Sarcoidosis, Pulmonary immunology, Sarcoidosis, Pulmonary genetics
Published
2003

12. HLA-DQB1*0201: a marker for good prognosis in British and Dutch patients with sarcoidosis.

Author

Sato H, Grutters JC, Pantelidis P, Mizzon AN, Ahmad T, Van Houte AJ, Lammers JW, Van Den Bosch JM, Welsh KI, and Du Bois RM

Subjects
ATP-Binding Cassette Transporters genetics, Adaptor Proteins, Signal Transducing, Alleles, Carbon Monoxide metabolism, DEAD-box RNA Helicases, Disease Progression, Electrophoresis, Polyacrylamide Gel, HLA-DQ Antigens metabolism, HLA-DQ beta-Chains, Haplotypes, Histocompatibility Antigens Class II genetics, Humans, Lymphotoxin-alpha genetics, Netherlands, Polymerase Chain Reaction, Prognosis, RNA Helicases, Respiratory Function Tests, Syndrome, Time Factors, Tumor Necrosis Factor-alpha genetics, United Kingdom, Genetic Markers, HLA-DQ Antigens genetics, Polymorphism, Genetic, Sarcoidosis diagnosis, Sarcoidosis genetics
Abstract

Human leukocyte antigen (HLA)-DQB1 is one of the intriguing candidate genes in sarcoidosis. We performed high resolution molecular HLA-DQB1 typing on two groups of white patients (British [UK] and Dutch [NL]) in order to investigate the relationship between 19 DQB1 alleles and disease severity and progression. A total of 803 individuals were studied (133 UK and 102 NL patients, and 354 UK and 214 NL control subjects). Disease severity data included extrapulmonary disease, chest X-ray stage, lung diffusing capacity for carbon monoxide, and FVC. Progression was evaluated on follow-up chest radiographs (2 and 4 yr). The results showed DQB1*0201 to be strongly protective against severe sarcoidosis in both populations; in other words, it localized to Stage I at all time points (P < 0.0001, P(corrected) (P(c)) = 0.002), whereas another DQB1 allele, *0602, tended to have opposite effects. Further, a clear association was found between the *0201 allele and Löfgren's syndrome (P < 0.0001, P(c) = 0.001). More importantly, carriage of this allele reduced the risk of disease progression. In contrast, the other common split of DQB1*02, *0202, did not affect disease severity but was mildly protective against sarcoidosis in the UK population (P = 0.02, p(c) not significant). In conclusion, this study shows that DQB1*0201 is a strong marker for mild sarcoidosis. Additional mapping across the DQB1*0201-DRB1*0301 haplotype, including specific alleles at genes such as DRB3, tumor necrosis factor, lymphotoxin-alpha, I-kappa-B-like protein, and B-associated transcript 1, is necessary for a final localization of the protective effect on this haplotype.

Published
2002
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13. Increased frequency of the uncommon tumor necrosis factor -857T allele in British and Dutch patients with sarcoidosis.

Author

Grutters JC, Sato H, Pantelidis P, Lagan AL, McGrath DS, Lammers JW, van den Bosch JM, Wells AU, du Bois RM, and Welsh KI

Subjects
Genotype, Haplotypes, Humans, Netherlands, Phenotype, Point Mutation, Polymerase Chain Reaction, Promoter Regions, Genetic genetics, United Kingdom, Gene Frequency, Polymorphism, Genetic, Sarcoidosis, Pulmonary genetics, Tumor Necrosis Factor-alpha genetics
Abstract

Interindividual variation in the expression of tumor necrosis factor (TNF)-alpha suggests the existence of functionally distinct TNF alleles, which might play a role in sarcoidosis. We investigated five potentially functional biallelic TNF promoter polymorphisms at nucleotide positions -1,031(T/C), -863(C/A), -857(C/T), -307(G/A), and -237(G/A) in two clinically well-defined groups of white patients (British [UK] and Dutch [NL]) with sarcoidosis, each with their own control subjects. Polymorphisms were determined using SSP-PCR. A total of 772 individuals were studied (96 UK patients, 354 UK control subjects, 100 NL patients, 222 NL controls). A significant increase in the rarer TNF -857T allele was found in both sarcoidosis populations. In total 25.5% of the sarcoid patients carried the TNF -857T allele versus 14.1% of the control subjects (p = 0.003, p(c) = 0.02). In the sarcoidosis group the allele frequency of this polymorphism was 13.5% versus 7.3% in the control subjects (p = 0.0003, p(c) = 0.002). Subgroup analysis showed a significant increase in the rarer TNF -307A (TNF-2) allele in patients with Löfgren's syndrome (p = 0.006, p(c) = 0.03). Our finding does not necessarily imply that the two polymorphisms relate to different functions; it may be that one or both are in linkage disequilibrium with the causal site. This requires further studies of functionality and linkage disequilibrium.

Published
2002
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