1. The IgA-pIgR System Is Dysregulated in Idiopathic Pulmonary Fibrosis.
- Author
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Planté-Bordeneuve, Thomas, Bertrand, Youri, Lecocq, Marylène, Hoton, Delphine, Fillée, Catherine, Lacroix, Valérie, Rondelet, Benoit, Wuyts, Wim, Bouzin, Caroline, Pilette, Charles, and Froidure, Antoine
- Subjects
IDIOPATHIC pulmonary fibrosis ,PROPORTIONAL hazards models ,IMMUNOLOGIC memory ,IMMUNOGLOBULIN receptors ,MANN Whitney U Test ,IMMUNOGLOBULIN M - Abstract
This letter, published in the American Journal of Respiratory & Critical Care Medicine, discusses the dysregulation of the IgA-pIgR system in idiopathic pulmonary fibrosis (IPF). The authors conducted a study to investigate the IgA-pIgR system in IPF, analyzing serum and lung tissue samples from IPF patients and control subjects. They found increased levels of IgA+ memory B cells and autoreactive IgA in IPF, suggesting a dysregulation of the IgA-pIgR system in this disease. The study also suggests a potential role of the IgA-pIgR system in epithelial-mesenchymal transition (EMT) and fibrotic features in IPF. Further research is needed to explore the implications of mucosal immunity in pulmonary fibrosis. [Extracted from the article]
- Published
- 2024
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