1. The Role of Exercise in a Weight-Loss Program on Clinical Control in Obese Adults with Asthma. A Randomized Controlled Trial
- Author
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Marcio C. Mancini, Patricia Duarte Freitas, Milton A. Martins, Celso R. F. Carvalho, Aline Grandi Silva, Palmira G. Ferreira, Frederico Leon Arrabal Fernandes, Rafael Stelmach, Maria Notomi Sato, and Regina Maria Carvalho-Pinto
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Psychological intervention ,Critical Care and Intensive Care Medicine ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,law ,Weight loss ,Humans ,Medicine ,Muscle Strength ,Obesity ,030212 general & internal medicine ,Exercise ,Lung ,Caloric Restriction ,Asthma ,Inflammation ,business.industry ,Resistance Training ,Weight Loss Program ,Middle Aged ,medicine.disease ,Respiratory Function Tests ,Weight Reduction Programs ,medicine.anatomical_structure ,030228 respiratory system ,Quality of Life ,Breathing ,Physical therapy ,Female ,medicine.symptom ,business ,Biomarkers - Abstract
Clinical control is difficult to achieve in obese patients with asthma. Bariatric surgery has been recommended for weight loss and to improve asthma control; however, the benefits of nonsurgical interventions have been poorly investigated.To examine the effect of exercise training in a weight-loss program on asthma control, quality of life, inflammatory biomarkers, and lung function.Fifty-five obese patients with asthma were randomly assigned to either a weight-loss program plus exercise (WL + E group, n = 28) or a weight-loss program plus sham (WL + S group, n = 27), where the weight-loss program included nutrition (caloric restriction) and psychological therapies. The WL + E group incorporated aerobic and resistance muscle training, whereas the WL + S group incorporated breathing and stretching exercises.The primary outcome was clinical improvement in asthma control over 3 months. Secondary outcomes included quality of life, lung function, body composition, aerobic capacity, muscle strength, and inflammatory/antiinflammatory biomarkers. After 3 months, 51 patients were analyzed. Compared with the WL + S group, the WL + E group demonstrated improved clinical control scores (median [25th to 75th percentile], -0.7 [-1.3 to -0.3] vs. -0.3 [-0.9 to 0.4]; P = 0.01) and greater weight loss (mean ± SD, -6.8% ± 3.5 vs. -3.1% ± 2.6; P 0.001) and aerobic capacity (median [25th to 75th percentile], 3.0 [2.4 to 4.0] vs. 0.9 [-0.3 to 1.3] ml OAdding exercise to a short-term weight-loss program should be considered as a useful strategy for achieving clinical control of asthma in obese patients. Clinical trial registered with www.clinicaltrials.gov (NCT 02188940).
- Published
- 2017