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Your search keyword '"Michelakis, Evangelos D."' showing total 7 results
Start Over Author "Michelakis, Evangelos D." Publisher american thoracic society
7 results on '"Michelakis, Evangelos D."'

2. Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement

Author

Lahm, Tim, primary, Douglas, Ivor S., additional, Archer, Stephen L., additional, Bogaard, Harm J., additional, Chesler, Naomi C., additional, Haddad, Francois, additional, Hemnes, Anna R., additional, Kawut, Steven M., additional, Kline, Jeffrey A., additional, Kolb, Todd M., additional, Mathai, Stephen C., additional, Mercier, Olaf, additional, Michelakis, Evangelos D., additional, Naeije, Robert, additional, Tuder, Rubin M., additional, Ventetuolo, Corey E., additional, Vieillard-Baron, Antoine, additional, Voelkel, Norbert F., additional, Vonk-Noordegraaf, Anton, additional, and Hassoun, Paul M., additional

Published
2018
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3. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension

Author

Boucherat, Olivier, primary, Peterlini, Thibaut, additional, Bourgeois, Alice, additional, Nadeau, Valérie, additional, Breuils-Bonnet, Sandra, additional, Boilet-Molez, Stéphanie, additional, Potus, François, additional, Meloche, Jolyane, additional, Chabot, Sophie, additional, Lambert, Caroline, additional, Tremblay, Eve, additional, Chae, Young Chan, additional, Altieri, Dario C., additional, Sutendra, Gopinath, additional, Michelakis, Evangelos D., additional, Paulin, Roxane, additional, Provencher, Steeve, additional, and Bonnet, Sébastien, additional

Published
2018
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4. A Phase-2 NIH-sponsored Randomized Clinical Trial of Rituximab in Scleroderma-associated Pulmonary Arterial Hypertension Did Not Reach Significance for Its Endpoints: End of Story? Not So Fast!

Author

Yongneng Zhang, Michelakis, Evangelos D., and Zhang, Yongneng

Subjects
RANDOMIZED controlled trials, RITUXIMAB, PULMONARY hypertension, CYTOKINES, INFLAMMATION
Abstract

An editorial is presented on the results of a randomized placebo-controlled clinical trial (RCT) of rituximab in scleroderma-associated pulmonary arterial hypertension (SSC-PAH). Topics include loss of the signal in vascular cells promoting proliferative vascular remodeling; inhibiting immunoglobulin production, differentiation, and proliferation; and producing many cytokines and promoting or suppressing the inflammation.

Published
2021
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5. Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI–Cardiovascular Medical Research and Education Fund Workshop Report

Author

Newman, John H., primary, Rich, Stuart, additional, Abman, Steven H., additional, Alexander, John H., additional, Barnard, John, additional, Beck, Gerald J., additional, Benza, Raymond L., additional, Bull, Todd M., additional, Chan, Stephen Y., additional, Chun, Hyung J., additional, Doogan, Declan, additional, Dupuis, Jocelyn, additional, Erzurum, Serpil C., additional, Frantz, Robert P., additional, Geraci, Mark, additional, Gillies, Hunter, additional, Gladwin, Mark, additional, Gray, Michael P., additional, Hemnes, Anna R., additional, Herbst, Roy S., additional, Hernandez, Adrian F., additional, Hill, Nicholas S., additional, Horn, Evelyn M., additional, Hunter, Kendall, additional, Jing, Zhi-Cheng, additional, Johns, Roger, additional, Kaul, Sanjay, additional, Kawut, Steven M., additional, Lahm, Tim, additional, Leopold, Jane A., additional, Lewis, Greg D., additional, Mathai, Stephen C., additional, McLaughlin, Vallerie V., additional, Michelakis, Evangelos D., additional, Nathan, Steven D., additional, Nichols, William, additional, Page, Grier, additional, Rabinovitch, Marlene, additional, Rich, Jonathan, additional, Rischard, Franz, additional, Rounds, Sharon, additional, Shah, Sanjiv J., additional, Tapson, Victor F., additional, Lowy, Naomi, additional, Stockbridge, Norman, additional, Weinmann, Gail, additional, and Xiao, Lei, additional

Published
2017
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6. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease

Author

Suratt, Benjamin T., primary, Ubags, Niki D. J., additional, Rastogi, Deepa, additional, Tantisira, Kelan G., additional, Marsland, Benjamin J., additional, Petrache, Irina, additional, Allen, Janice B., additional, Bates, Jason H. T., additional, Holguin, Fernando, additional, McCormack, Meredith C., additional, Michelakis, Evangelos D., additional, Black, Stephen M., additional, Jain, Manu, additional, Mora, Ana L., additional, Natarajan, Viswanathan, additional, Miller, Yury I., additional, Fessler, Michael B., additional, Birukov, Konstantin G., additional, Summer, Ross S., additional, Shore, Stephanie A., additional, and Dixon, Anne E., additional

Published
2017
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7. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.

Author

Boucherat, Olivier, Peterlini, Thibaut, Bourgeois, Alice, Nadeau, Valérie, Breuils-Bonnet, Sandra, Boilet-Molez, Stéphanie, Potus, François, Meloche, Jolyane, Chabot, Sophie, Lambert, Caroline, Tremblay, Eve, Young Chan Chae, Altieri, Dario C., Sutendra, Gopinath, Michelakis, Evangelos D., Paulin, Roxane, Provencher, Steeve, and Bonnet, Sébastien

Subjects
VASCULAR remodeling, PULMONARY hypertension, MOLECULAR chaperones, CELL proliferation, IMMUNOFLUORESCENCE
Abstract

Rationale: Pulmonary arterial hypertension (PAH) is a vascular remodeling disease with a poor prognosis and limited therapeutic options. Although the mechanisms contributing to vascular remodeling in PAH are still unclear, several features, including hyperproliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs), have led to the emergence of the cancer-like concept. The molecular chaperone HSP90 (heat shock protein 90) is directly associated with malignant growth and proliferation under stress conditions. In addition to being highly expressed in the cytosol, HSP90 exists in a subcellular pool compartmentalized in the mitochondria (mtHSP90) of tumor cells, but not in normal cells, where it promotes cell survival. Objectives: We hypothesized that mtHSP90 in PAH-PASMCs represents a protective mechanism against stress, promoting their proliferation and resistance to apoptosis. Methods: Expression and localization of HSP90 were analyzed by Western blot, immunofluorescence, and immunogold electron microscopy. In vitro, effects of mtHSP90 inhibition on mitochondrial DNA integrity, bioenergetics, cell proliferation and resistance to apoptosis were assessed. In vivo, the therapeutic potential of Gamitrinib, a mitochondria-targeted HSP90 inhibitor, was tested in fawn-hooded and monocrotaline rats. Measurements and Main Results: We demonstrated that, in response to stress, HSP90 preferentially accumulates in PAHPASMC mitochondria (dual immunostaining, immunoblot, and immunogold electron microscopy) to ensure cell survival by preserving mitochondrial DNA integrity and bioenergetic functions. Whereas cytosolic HSP90 inhibition displays a lack of absolute specificity for PAH-PASMCs, Gamitrinib decreased mitochondrial DNA content and repair capacity and bioenergetic functions, thus repressing PAH-PASMC proliferation (Ki67 labeling) and resistance to apoptosis (Annexin V assay) without affecting control cells. In vivo, Gamitrinib improvesPAHin two experimental rat models (monocrotaline and fawn-hooded rat). Conclusions: Our data show for the first time that accumulation of mtHSP90 is a feature of PAH-PASMCs and a key regulator of mitochondrialhomeostasis contributing to vascular remodeling inPAH. [ABSTRACT FROM AUTHOR]

Published
2018
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