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Your search keyword '"Chirag A. Shah"' showing total 10 results
Start Over Author "Chirag A. Shah" Publisher american thoracic society
10 results on '"Chirag A. Shah"'

1. Somatic Mutations at Single Base Resolution in Single Bronchial Progenitor Cells Collected from Human Lung

Author

A. Maslov, Miao Shi, Jan Vijg, Aditi Desai, S. Waldman, Shixiang Sun, A. Marsh, T. Siddiqui, Z. Huang, Simon D. Spivack, Ali Sadoughi, Y. Peter, Moonsook Lee, J. R. Patel, Chirag D. Shah, and D. Patel

Subjects
medicine.anatomical_structure, Somatic cell, Resolution (electron density), medicine, Biology, Progenitor cell, Base (exponentiation), Molecular biology, Human lung
Published
2021
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2. The Impact of a Structured Multi-Disciplinary Early Mobilization Program on Clinical Outcomes in Hospitalized Patients with Pneumonia and Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Author

M.E. Kendra, J. Corasaniti, Chirag V. Shah, Stephanie Chiu, F. Cerrone, C. Mazzei, E.A. Dimitry, J. Calvert, G.C. Choi, R. D'Achille, L. Landry, K. Fitzpatrick, E. Cahill, B. Fetherman, Beverly Natale, B. Daley, O.H. Mahmoud, and N. Reyes

Subjects
Pneumonia, medicine.medical_specialty, Multi disciplinary, business.industry, Hospitalized patients, medicine, Pulmonary disease, Early mobilization, medicine.disease, Intensive care medicine, business
Published
2020
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4. Plasma Levels of Receptor for Advanced Glycation End Products, Blood Transfusion, and Risk of Primary Graft Dysfunction

Author

Jason D, Christie, Chirag V, Shah, Steven M, Kawut, Nilam, Mangalmurti, David J, Lederer, Joshua R, Sonett, Vivek N, Ahya, Scott M, Palmer, Keith, Wille, Vibha, Lama, Pali D, Shah, Ashish, Shah, Ann, Weinacker, Clifford S, Deutschman, Benjamin A, Kohl, Ejigayehu, Demissie, Scarlett, Bellamy, Lorraine B, Ware, and Ashley, Finlen-Copeland

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Resuscitation, Time Factors, Blood transfusion, medicine.medical_treatment, Receptor for Advanced Glycation End Products, Blood Component Transfusion, Critical Care and Intensive Care Medicine, Gastroenterology, law.invention, Cohort Studies, law, Blood product, Intensive care, Internal medicine, Cardiopulmonary bypass, medicine, Humans, Lung transplantation, Prospective Studies, Receptors, Immunologic, Prospective cohort study, business.industry, Middle Aged, respiratory system, Surgery, Transplantation, Female, lipids (amino acids, peptides, and proteins), Primary Graft Dysfunction, business, Biomarkers, Lung Transplantation
Abstract

Rationale:Thereceptorforadvancedglycationendproducts(RAGE) is an important marker of lung epithelial injury and may be associated with impaired alveolar fluid clearance. We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD. Objectives:TotesttheassociationofsolubleRAGE(sRAGE)levelswith PGD in a prospective, multicenter cohort study. Methods: We measured plasma levels of sRAGE at 6 and 24 hours afterallograftreperfusion in317 lungtransplantrecipientsatseven centers. The primary outcome was grade 3 PGD (PaO2 /FIO2 , 200 with alveolar infiltrates) within the first 72 hours after transplantation. Measurements and Main Results: Patients who developed PGD had higher levels of sRAGE than patients without PGD at both 6 hours (median 9.3 ng/ml vs. 7.5 ng/ml, respectively; P 5 0.028) and at 24 hours post-transplantation (median 4.3 ng/ml vs. 1.9 ng/ml, respectively; P , 0.001). Multivariable logistic regression analyses indicated that the relationship between levels of sRAGE and PGD was attenuated by elevated right heart pressures and by the use of cardiopulmonary bypass. Median sRAGE levels were higher in subjects with cardiopulmonary bypass at both 6 hours (P 5 0.003) and 24 hours (P , 0.001). sRAGE levels at 6 hours were significantly associated with intraoperative red cell transfusion (Spearman’s r 5 0.39, P 5 0.002 in those with PGD), and in multivariable linear regression analyses this association was independent of confounding variables (P 5 0.02). Conclusions: Elevated plasma levels of sRAGE are associated with PGD after lung transplantation. Furthermore, plasma sRAGE levels are associated with blood product transfusion and use of cardiopulmonary bypass.

Published
2009
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6. Emergency Department Antithrombin III And Plasminogen Activator Inhibitor-1 Initial Plasma Levels Are Associated With Acute Lung Injury In Patients With Severe Sepsis And Septic Shock

Author

David F. Gaieski, Barry D. Fuchs, Nuala J. Meyer, Chirag V. Shah, Mark E. Mikkelsen, Jason D. Christie, Nancy E. Kohn, Judd E. Hollander, Michael G.S. Shashaty, and Shiv Kapoor

Subjects
medicine.medical_specialty, business.industry, Septic shock, Antithrombin, Emergency department, Plasma levels, Lung injury, medicine.disease, Surgery, chemistry.chemical_compound, chemistry, Anesthesia, Plasminogen activator inhibitor-1, Medicine, In patient, business, Severe sepsis, medicine.drug
Published
2010
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9. Lower Serum Endocan Levels Are Associated with the Development of Acute Lung Injury after Major Trauma

Author

Scarlett L. Bellamy, Chirag V. Shah, Philippe Lassalle, Nuala J. Meyer, Nathalie De Freitas Caires, Arnaud Scherpereel, Steven M. Albelda, Robert Gallop, Barry D. Fuchs, Jason D. Christie, A R. Localio, and Paul N. Lanken

Subjects
medicine.medical_specialty, business.industry, Major trauma, medicine, Lung injury, Intensive care medicine, medicine.disease, business
Published
2009
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