1. Cessation of Long-term Treatment with Inhaled Corticosteroid (Budesonide) in Children with Asthma Results in Deterioration
- Author
-
Jgr Demonchy, Sj Pocock, J Kreukniet, P. J. Sterk, P.N.R. Dekhuijzen, Pm Dejong, B Vanderbruggen, C.M. Roos, H. J. Waalkens, Hm Jansen, Cla Vanherwaarden, Je Prinsen, DA Meyers, Paulus Brand, Huib A. M. Kerstjens, C Hilvering, A deGooijer, Eem Vanesenzandvliet, Jorrit Gerritsen, K. F. Kerrebijn, Gh Koeter, Tw Vandermark, Dfme Schoonbrood, Hughes, Jm Kouwenberg, Dirkje S. Postma, Fw Dekker, Se Overbeek, Amj Wever, P. H. Quanjer, Hj Sluiter, Aa Kaptein, Pjfm Merkus, Ee Vanessenzandvliet, K. Knol, Jm Bogaard, Nj Robinson, E. J. Duiverman, Em Pouw, Hans Th.M. Folgering, Sj Gans, Hjj Mengelers, and ER Bleecker
- Subjects
Pulmonary and Respiratory Medicine ,Budesonide ,medicine.drug_class ,business.industry ,Terbutaline ,medicine.disease ,Placebo ,law.invention ,Randomized controlled trial ,law ,Anesthesia ,medicine ,Prednisolone ,Salbutamol ,Corticosteroid ,business ,medicine.drug ,Asthma - Abstract
Inhaled corticosteroid has been shown to be effective in the management of asthma. However, there is a lack of studies that assess the effect of cessation after long-term treatment with inhaled corticosteroid. This question was addressed in 28 children with stable asthma, aged 11 to 18 yr of age, who had completed 28 to 36 months of treatment with inhaled corticosteroid (budesonide 200 µg 3 times/day) and inhaled β-2-agonist (salbutamol 200 µg 3 times/day). The children were randomized in a 1:2 ratio in a double-blind study either to continue budesonide (n = 8) during a period of 6 months or to decrease the dose of budesonide (n = 20) within 2 months, followed by placebo for 4 months. Treatment with salbutamol 600 µg daily was continued in both groups. Eight children from the tapering-off group withdrew, mainly due to symptoms of asthma, compared with none in the continuous treatment group. Five patients in the tapering-off group experienced exacerbations for which prednisolone was given, compared with no...
- Published
- 1993
- Full Text
- View/download PDF