1. Regional variation in the correlation of antibody and T-cell responses to Trypanosoma cruzi
- Author
-
Patricia Escalante, César Náquira, Diana L. Martin, Morgan A. Marks, Lisbeth Ferrufino, Gerardo Sanchez, Anthony Halperin, Manuela Verastegui, Caryn Bern, Robert H. Gilman, Gerson Galdos-Cardenas, Michael J. Levy, and E. Brook Goodhew
- Subjects
Chagas disease ,Adult ,Male ,Bolivia ,T-Lymphocytes ,Trypanosoma cruzi ,T cell ,Antibodies, Protozoan ,Sensitivity and Specificity ,Serology ,Interferon-gamma ,Virology ,parasitic diseases ,Peru ,medicine ,Humans ,Chagas Disease ,Interferon gamma ,Serologic Tests ,Antibodies, Protozoan/blood ,Interferon-gamma/metabolism ,biology ,Geography ,Antibody titer ,Articles ,Middle Aged ,T-Lymphocytes/immunology ,medicine.disease ,biology.organism_classification ,Chagas Disease/diagnosis/immunology ,Infectious Diseases ,medicine.anatomical_structure ,Regional variation ,Immunology ,biology.protein ,Parasitology ,Female ,Trypanosoma cruzi/immunology ,Antibody ,purl.org/pe-repo/ocde/ford#3.03.06 [https] ,medicine.drug - Abstract
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T. cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-gamma (IFNgamma)-secreting cells from Peruvian samples. However, the magnitude of the IFNgamma response was similar among the IFNgamma responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses.
- Published
- 2014