1. Seroprevalence of neutralizing antibodies against dengue virus in two localities in the state of Morelos, Mexico.
- Author
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Amaya-Larios IY, Martínez-Vega RA, Mayer SV, Galeana-Hernández M, Comas-García A, Sepúlveda-Salinas KJ, Falcón-Lezama JA, Vasilakis N, and Ramos-Castañeda J
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Cross-Sectional Studies, Dengue immunology, Female, Humans, Immunoglobulin G blood, Male, Mexico epidemiology, Seroepidemiologic Studies, Serotyping, Young Adult, Antibodies, Neutralizing blood, Antibodies, Viral blood, Dengue epidemiology, Dengue Virus isolation & purification
- Abstract
Humoral immune response against dengue virus (DENV) is an important component in dengue-endemic transmission. We conducted a cross-sectional nested cohort study to determine the seroprevalence and frequency of neutralizing antibodies against DENV serotypes in two endemic localities in the state of Morelos, Mexico. The cohort participants (N = 1,196) were screened to determine previous exposure to DENV. Overall seroprevalence was 76.6% (95% confidence interval [95% CI] = 73.6-79.2), and prevalence of neutralizing antibodies in the 5- to 9-year-old group was 82.5% (95% CI = 67.2-92.7), 45% (95% CI = 29.3-61.5), and 65% (95% CI = 48.3-79.4) for DENV-1, DENV-2, and DENV-3, respectively. For participants older than 10 years, the observed seroprevalence was above 60% for each serotype, except DENV-4 in the 10- to 25-year-old group (42.9%); 81% of humoral responses were multitypic. The outcomes of our study contribute to understanding the immune component of dengue transmission and provide focal information for the evaluation of vaccine candidates under development., (© The American Society of Tropical Medicine and Hygiene.)
- Published
- 2014
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