1. Schistosoma mansoni Morbidity among School-Aged Children: A SCORE Project in Kenya
- Author
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Geoffrey Muchiri, Ryan E. Wiegand, Elizabeth Matey, W. Evan Secor, Edmund Ireri, Diana M. S. Karanja, Aaron M. Samuels, Susan P. Montgomery, Pauline N. M. Mwinzi, and Molly Hyde
- Subjects
Male ,medicine.medical_specialty ,Cross-sectional study ,Anemia ,Schistosomiasis ,Virology ,Internal medicine ,parasitic diseases ,medicine ,Animals ,Humans ,Child ,Parasite Egg Count ,Ultrasonography ,biology ,business.industry ,Articles ,Schistosoma mansoni ,Odds ratio ,Anthropometry ,medicine.disease ,biology.organism_classification ,Kenya ,Cross-Sectional Studies ,Infectious Diseases ,Immunology ,Exercise Test ,Quality of Life ,Female ,Parasitology ,business ,Malaria ,Cohort study - Abstract
Schistosomiasis control programs aim to reduce morbidity but are evaluated by infection prevalence and intensity reduction. We present baseline cross-sectional data from a nested cohort study comparing indicators of mor- bidity for measuring program impact. Eight hundred twenty-two schoolchildren 7-8 years of age from Nyanza Province, Kenya, contributed stool for diagnosis of Schistosoma mansoni and soil-transmitted helminths (STH) and blood smears for malaria, and were evaluated for anemia, quality of life, exercise tolerance, anthropometry, and ultrasound abnormal- ities. Schistosoma mansoni, STH, and malaria infection prevalence were 69%, 25%, and 8%, respectively. Only anemia and S. mansoni infection (adjusted odds ratio (aOR) = 1.70; confidence interval (CI) = 1.03-2.80), and hepatomegaly and heavy S. mansoni infection (aOR = 2.21; CI = 1.19-4.11) were associated. Though anemia and hepatomegaly appeared most useful at baseline, additional morbidity indicators may be sensitive longitudinal measures to evaluate schistosomi- asis program health impact.
- Published
- 2012