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Start Over Author "Arnold, Benjamin F" Publisher american society of tropical medicine and hygiene
30 results on '"Arnold, Benjamin F"'

1. Gut Microbiome Diversity and Antimicrobial Resistance After a Single Dose of Oral Azithromycin in Children: A Randomized Placebo-Controlled Trial

Author

Doan, Thuy, primary, Liu, Zijun, additional, Sié, Ali, additional, Dah, Clarisse, additional, Bountogo, Mamadou, additional, Ouattara, Mamadou, additional, Coulibaly, Boubacar, additional, Kiemde, Dramane, additional, Zonou, Guillaume, additional, Nebie, Eric, additional, Brogdon, Jessica, additional, Lebas, Elodie, additional, Hinterwirth, Armin, additional, Zhong, Lina, additional, Chen, Cindi, additional, Zhou, Zhaoxia, additional, Porco, Travis, additional, Arnold, Benjamin F., additional, Oldenburg, Catherine E., additional, and Lietman, Thomas M., additional

Published
2024
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2. Anthropometric Differences in Community- Versus Clinic-Recruited Infants Participating in a Trial of Azithromycin for Prevention of Childhood Mortality in Burkina Faso

Author

Ouattara, Mamadou, primary, Sié, Ali, additional, Bountogo, Mamadou, additional, Boudo, Valentin, additional, Dah, Clarisse, additional, Lebas, Elodie, additional, Hu, Huiyu, additional, Porco, Travis C., additional, Arnold, Benjamin F., additional, Lietman, Thomas M., additional, and Oldenburg, Catherine E., additional

Published
2023
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3. Neonatal Azithromycin Administration and Growth during Infancy: A Randomized Controlled Trial

Author

Sie, Ali, primary, Bountogo, Mamadou, additional, Zakane, Alphonse, additional, Compaoré, Guillaume, additional, Ouedraogo, Thierry, additional, Ouattara, Mamadou, additional, Lebas, Elodie, additional, Brogdon, Jessica, additional, Nyatigo, Fanice, additional, O’Brien, Kieran S., additional, Porco, Travis C., additional, Bärnighausen, Till, additional, Arnold, Benjamin F., additional, Lietman, Thomas M., additional, Oldenburg, Catherine E., additional, and _, _, additional

Published
2023
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4. The Association between Malnutrition and Malaria Infection in Children under 5 Years in Burkina Faso: A Longitudinal Study

Author

Gebreegziabher, Elisabeth, primary, Dah, Clarisse, additional, Coulibaly, Boubacar, additional, Sie, Ali, additional, Bountogo, Mamadou, additional, Ouattara, Mamadou, additional, Compaoré, Adama, additional, Nikiema, Moustapha, additional, Tiansi, Jérôme, additional, Dembélé, Nestor, additional, Lebas, Elodie, additional, Roh, Michelle, additional, Glidden, David V., additional, Arnold, Benjamin F., additional, Lietman, Thomas M., additional, and Oldenburg, Catherine E., additional

Published
2023
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5. Gut Microbiome among Children with Uncomplicated Severe Acute Malnutrition in a Randomized Controlled Trial of Azithromycin versus Amoxicillin

Author

Oldenburg, Catherine E., primary, Hinterwirth, Armin, additional, Dah, Clarisse, additional, Millogo, Ourohiré, additional, Coulibaly, Boubacar, additional, Ouedraogo, Moussa, additional, Sié, Ali, additional, Chen, Cindi, additional, Zhong, Lina, additional, Ruder, Kevin, additional, Lebas, Elodie, additional, Nyatigo, Fanice, additional, Arnold, Benjamin F., additional, O’Brien, Kieran S., additional, and Doan, Thuy, additional

Published
2023
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6. Effect of Neonatal Azithromycin on All-Cause and Cause-Specific Infant Mortality: A Randomized Controlled Trial

Author

Sié, Ali, primary, Bountogo, Mamadou, additional, Zakane, Alphonse, additional, Compaoré, Guillaume, additional, Ouedraogo, Thierry, additional, Lebas, Elodie, additional, Nyatigo, Fanice, additional, Hu, Huiyu, additional, Brogdon, Jessica, additional, Arnold, Benjamin F., additional, Lietman, Thomas M., additional, Oldenburg, Catherine E., additional, and _, _, additional

Published
2022
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7. Gut Resistome after Antibiotics among Children with Uncomplicated Severe Acute Malnutrition: A Randomized Controlled Trial

Author

Oldenburg, Catherine E., primary, Hinterwirth, Armin, additional, Ourohiré, Millogo, additional, Dah, Clarisse, additional, Ouédraogo, Moussa, additional, Sié, Ali, additional, Boudo, Valentin, additional, Chen, Cindi, additional, Ruder, Kevin, additional, Zhong, Lina, additional, Lebas, Elodie, additional, Nyatigo, Fanice, additional, Arnold, Benjamin F., additional, O’Brien, Kieran S., additional, and Doan, Thuy, additional

Published
2022
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8. Epidemiology of Underweight among Infants in Rural Burkina Faso

Author

Sié, Ali, primary, Ouattara, Mamadou, additional, Bountogo, Mamadou, additional, Dah, Clarisse, additional, Compaore, Guillaume, additional, Lebas, Elodie, additional, Brogdon, Jessica M., additional, Lin, Ying, additional, Godwin, William W., additional, O’Brien, Kieran S., additional, Arnold, Benjamin F., additional, Lietman, Thomas M., additional, Oldenburg, Catherine E., additional, and _, _, additional

Published
2021
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9. Azithromycin versus Amoxicillin and Malarial Parasitemia among Children with Uncomplicated Severe Acute Malnutrition: A Randomized Controlled Trial

Author

Sié, Ali, primary, Dah, Clarisse, additional, Ourohiré, Millogo, additional, Ouédraogo, Moussa, additional, Boudo, Valentin, additional, Arzika, Ahmed M., additional, Lebas, Elodie, additional, Nyatigo, Fanice, additional, Arnold, Benjamin F., additional, O’Brien, Kieran S., additional, and Oldenburg, Catherine E., additional

Published
2021
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10. Precision of Serologic Testing from Dried Blood Spots Using a Multiplex Bead Assay

Author

Gwyn, Sarah, primary, Aragie, Solomon, additional, Wittberg, Dionna M., additional, Melo, Jason S., additional, Dagnew, Adane, additional, Hailu, Dagnachew, additional, Tadesse, Zerihun, additional, Haile, Mahteme, additional, Zeru, Taye, additional, Nash, Scott D., additional, Arnold, Benjamin F., additional, Martin, Diana L., additional, and Keenan, Jeremy D., additional

Published
2021
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11. Access to Improved Sanitation and Nutritional Status among Preschool Children in Nouna District, Burkina Faso

Author

Bountogo, Mamadou, primary, Ouattara, Mamadou, additional, Sié, Ali, additional, Compaoré, Guillaume, additional, Dah, Clarisse, additional, Boudo, Valentin, additional, Zakane, Alphonse, additional, Lebas, Elodie, additional, Brogdon, Jessica M., additional, Godwin, William W., additional, Lin, Ying, additional, Arnold, Benjamin F., additional, Oldenburg, Catherine E., additional, and _, _, additional

Published
2021
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12. Population-Based Prevalence of Chlamydia trachomatis Infection and Antibodies in Four Districts with Varying Levels of Trachoma Endemicity in Amhara, Ethiopia

Author

Nash, Scott D., primary, Astale, Tigist, additional, Nute, Andrew W., additional, Bethea, Danaya, additional, Chernet, Ambahun, additional, Sata, Eshetu, additional, Zerihun, Mulat, additional, Gessese, Demelash, additional, Ayenew, Gedefaw, additional, Ayele, Zebene, additional, Melak, Berhanu, additional, Haile, Mahteme, additional, Zeru, Taye, additional, Tadesse, Zerihun, additional, Arnold, Benjamin F., additional, Callahan, Elizabeth Kelly, additional, and Martin, Diana L., additional

Published
2021
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13. Effects of Individual and Combined Water, Sanitation, Handwashing, and Nutritional Interventions on Child Respiratory Infections in Rural Kenya: A Cluster-Randomized Controlled Trial

Author

Swarthout, Jenna, primary, Ram, Pavani K., additional, Arnold, Charles D., additional, Dentz, Holly N., additional, Arnold, Benjamin F., additional, Kalungu, Stephen, additional, Lin, Audrie, additional, Njenga, Sammy M., additional, Stewart, Christine P., additional, Colford, John M., additional, Null, Clair, additional, and Pickering, Amy J., additional

Published
2020
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14. Effect of Improved Water Quality, Sanitation, Hygiene and Nutrition Interventions on Respiratory Illness in Young Children in Rural Bangladesh: A Multi-Arm Cluster-Randomized Controlled Trial

Author

Ashraf, Sania, primary, Islam, Mahfuza, additional, Unicomb, Leanne, additional, Rahman, Mahbubur, additional, Winch, Peter J., additional, Arnold, Benjamin F., additional, Benjamin-Chung, Jade, additional, Ram, Pavani K., additional, Colford, John M., additional, and Luby, Stephen P., additional

Published
2020
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16. Defining Diarrhea: A Population-Based Validation Study of Caregiver-Reported Stool Consistency in the Amhara Region of Ethiopia

Author

Aiemjoy, Kristen, primary, Callahan, Kelly, additional, Freeman, Mathew, additional, Neuhaus, John, additional, Arnold, Benjamin F., additional, Aragie, Solomon, additional, Keenan, Jeremy D., additional, Dagnew, Adane, additional, Gebresillasie, Sintayehu, additional, Fry, Dionna M., additional, Hailu, Dagnachew, additional, Stewart, Aisha, additional, Chanyalew, Melsew, additional, and Tadesse, Zerihun, additional

Published
2018
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19. Population Density, Poor Sanitation, and Enteric Infections in Nueva Santa Rosa, Guatemala

Author

Jarquin, Claudia, primary, Arnold, Benjamin F., additional, Muñoz, Fredy, additional, Lopez, Beatriz, additional, Cuéllar, Victoria M., additional, Thornton, Andrew, additional, Patel, Jaymin, additional, Reyes, Lisette, additional, Roy, Sharon L., additional, Bryan, Joe P., additional, McCracken, John P., additional, and Colford, John M., additional

Published
2016
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23. H2S as an Indicator of Water Supply Vulnerability and Health Risk in Low-Resource Settings: A Prospective Cohort Study

Author

Khush, Ranjiv S., primary, Ramaswamy, Padmavathi, additional, Arnold, Benjamin F., additional, Colford, John M., additional, Balakrishnan, Kalpana, additional, Ramaprabha, Prabhakar, additional, Durairaj, Natesan, additional, Srikanth, Padma, additional, Rajkumar, Paramasivan, additional, London, Alicia G., additional, and Sudharsanam, Suchithra, additional

Published
2013
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27. Cause-Specific Mortality among Infants in a Randomized Controlled Trial of Azithromycin Compared to Placebo for Prevention of Mortality.

Author

Ouattara M, Sié A, Bountogo M, Boudo V, Ouedraogo T, Dah C, Lebas E, Hu H, Lansdale A, Fetterman I, Arnold BF, Lietman TM, and Oldenburg CE

Abstract

Although community randomized trials have found a reduction in all-cause child mortality in communities receiving mass azithromycin distribution compared with placebo, individually randomized trials have not found similar protective effects. If a direct effect of azithromycin for prevention of child mortality exists, it is likely due to reduction in infectious mortality. Here, we assessed cause-specific mortality in a large randomized controlled trial of azithromycin administered during well-infant visits in Burkina Faso for prevention of mortality. Among 32,877 enrolled infants, the most common causes of death by 6 months of age were malaria, acute respiratory infections, and diarrheal disease. We found no evidence of a difference in the distribution of cause of death by randomized treatment assignment (P = 0.42) or in any infectious-specific cause of death. The results of this analysis are consistent with no direct effect of azithromycin on infant mortality when administered during well-infant visits.

Published
2024
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28. Gut Microbiome among Children with Uncomplicated Severe Acute Malnutrition in a Randomized Controlled Trial of Azithromycin versus Amoxicillin.

Author

Oldenburg CE, Hinterwirth A, Dah C, Millogo O, Coulibaly B, Ouedraogo M, Sié A, Chen C, Zhong L, Ruder K, Lebas E, Nyatigo F, Arnold BF, O'Brien KS, and Doan T

Subjects
Child, Humans, Infant, Azithromycin therapeutic use, Amoxicillin therapeutic use, Anti-Bacterial Agents therapeutic use, Gastrointestinal Microbiome, Severe Acute Malnutrition, Malnutrition
Abstract

Antibiotics are routinely used as part of the management of severe acute malnutrition and are known to reduce gut microbial diversity in non-malnourished children. We evaluated gut microbiomes in children participating in a randomized controlled trial (RCT) of azithromycin versus amoxicillin for severe acute malnutrition. Three hundred one children aged 6 to 59 months with uncomplicated severe acute malnutrition (mid-upper arm circumference < 11.5 cm and/or weight-for-height Z-score < -3 without clinical complications) were enrolled in a 1:1 RCT of single-dose azithromycin versus a 7-day course of amoxicillin (standard of care). Of these, 109 children were randomly selected for microbiome evaluation at baseline and 8 weeks. Rectal swabs were processed with metagenomic DNA sequencing. We compared alpha diversity (inverse Simpson's index) at 8 weeks and evaluated relative abundance of microbial taxa using DESeq2. Of 109 children enrolled in the microbiome study, 95 were followed at 8 weeks. We found no evidence of a difference in alpha diversity between the azithromycin and amoxicillin groups at 8 weeks controlling for baseline diversity (mean difference -0.6, 95% CI -1.8 to 0.6, P = 0.30). Gut microbiomes did not diversify during the study. Differentially abundant genera at the P < 0.01 level included Salmonella spp. and Shigella spp., both of which were overabundant in the azithromycin compared with amoxicillin groups. We found no evidence to support an overall difference in gut microbiome diversity between azithromycin and amoxicillin among children with uncomplicated severe acute malnutrition, but potentially pathogenic bacteria that can cause invasive diarrhea were more common in the azithromycin group. Trial Registration: ClinicalTrials.gov NCT03568643.

Published
2022
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29. Comparing Azithromycin to Amoxicillin in the Management of Uncomplicated Severe Acute Malnutrition in Burkina Faso: A Pilot Randomized Trial.

Author

O'Brien KS, Sié A, Dah C, Ourohiré M, Ouedraogo M, Boudo V, Arzika A, Lebas E, Nyatigo F, Godwin W, Kelly JD, Arnold BF, and Oldenburg CE

Subjects
Amoxicillin therapeutic use, Anti-Bacterial Agents therapeutic use, Azithromycin adverse effects, Burkina Faso, Child, Child, Preschool, Humans, Infant, Pilot Projects, Treatment Outcome, Weight Gain, Malnutrition, Severe Acute Malnutrition drug therapy
Abstract

Azithromycin is a promising alternative to amoxicillin in the management of uncomplicated severe acute malnutrition (SAM) as it can be administered as a single dose and has efficacy against several pathogens causing infectious disease and mortality in children under 5. In this pilot trial, we aimed to establish the feasibility of a larger randomized controlled trial and provide preliminary evidence comparing the effect of azithromycin to amoxicillin on weight gain in children with uncomplicated SAM. We enrolled children 6-59 months old with uncomplicated SAM at six healthcare centers in Burkina Faso. Participants were randomized to a single dose of azithromycin or a 7-day course of amoxicillin and followed weekly until nutritional recovery and again at 8 weeks. Apart from antibiotics, participants received standard of care, which includes ready-to-use therapeutic food. Primary feasibility outcomes included enrollment potential, refusals, and loss to follow-up. The primary clinical outcome was weight gain (g/kg/day) over 8 weeks. Outcome assessors were masked. Between June and October 2020, 312 children were screened, 301 were enrolled with zero refusals, and 282 (93.6%) completed the 8-week visit. Average weight gain was 2.5 g/kg/day (standard deviation [SD] 2.0) in the azithromycin group and 2.6 (SD 1.7) in the amoxicillin group (mean difference -0.1, 95% CI -0.5 to 0.3, P = 0.63). Fewer adverse events were reported in the azithromycin group (risk ratio 0.50, 95% CI 0.31-0.82, P = 0.006). With strong enrollment and follow-up, a fully powered trial in this setting is feasible.

Published
2022
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30. Adverse Events and Clinic Visits following a Single Dose of Oral Azithromycin among Preschool Children: A Randomized Placebo-Controlled Trial.

Author

Sié A, Dah C, Bountogo M, Ouattara M, Nebie E, Coulibaly B, Brogdon JM, Godwin WW, Lebas E, Doan T, Arnold BF, Porco TC, Lietman TM, and Oldenburg CE

Subjects
Administration, Oral, Ambulatory Care, Anti-Bacterial Agents pharmacology, Azithromycin pharmacology, Burkina Faso, Child Mortality, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Anti-Bacterial Agents administration & dosage, Anti-Bacterial Agents adverse effects, Azithromycin administration & dosage, Azithromycin adverse effects
Abstract

Biannual mass azithromycin distribution reduces all-cause child mortality in some settings in sub-Saharan Africa; however, adverse events and short-term infectious outcomes following treatment have not been well characterized. Children aged 0-59 months were recruited in Nouna Town, Burkina Faso, and randomized 1:1 to a single directly observed oral 20 mg/kg dose of azithromycin or placebo. At 14 days after treatment, caregivers were interviewed about adverse event symptoms their child experienced since treatment and if they had sought health care for their child. All children had tympanic temperature measured at the 14-day visit. We compared adverse events and clinic visits using logistic regression models between azithromycin- and placebo-controlled children. Of 450 children enrolled, 230 were randomized to azithromycin and 220 to placebo. On average, children were aged 28 months, and 50.9% were female. Caregivers of 20% of children reported that their child experienced at least one adverse event, with no significant difference between study arms (19.9% azithromycin; 20.0% placebo, logistic regression P = 0.96). Vomiting was more often reported by caregivers of azithromycin-treated children than by those of placebo-treated children (7.2% azithromycin, 1.9% placebo, logistic regression P = 0.01). There were no significant differences in other adverse events or clinic visits. Adverse events following a single oral dose of azithromycin in preschool children were rare and mild. Azithromycin administration appears safe in this population.

Published
2020
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