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This paper details the design and operation of a testbed to evaluate the concept of autonomous manufacturing to achieve a desired manufactured part performance specification. This testbed, the autonomous manufacturing system for phononic crystals (AMSPnC), is composed of additive manufacturing, material transport, ultrasonic testing, and cognition subsystems. Critically, the AMSPnC exhibits common manufacturing deficiencies such as process operating window limits, process uncertainty, and probabilistic failure. A case study illustrates the AMSPnC function using a standard supervised learning model trained by printing and testing an array of 48 unique designs that span the allowable design space. Using this model, three separate performance specifications are defined and an optimization algorithm is applied to autonomously select three corresponding design sets to achieve the specified performance. Validation manufacturing and testing confirms that two of the three optimal designs, as defined by an objective function, achieve the desired performance, with the third being outside the design window in which a distinct bandpass is achieved in phononic crystals (PnCs). Furthermore, across all samples, there is a marked difference between the observed bandpass characteristics and predictions from finite elements method computation, highlighting the importance of autonomous manufacturing for complex manufacturing objectives. [ABSTRACT FROM AUTHOR]