1. Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II
- Author
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Ran Tur-Kaspa, Yona Kitay-Cohen, Aliza Amiel, Moshe Fejgin, Nir Hilzenrat, Dan Buskila, Yaffa Ashur, Elena Gaber, Rifaat Safadi, and Michael Lishner
- Subjects
Hepatitis ,Hepatitis C virus ,Immunology ,virus diseases ,Chromosomal translocation ,Hepatitis C ,Gene rearrangement ,Cell Biology ,Hematology ,Biology ,medicine.disease_cause ,Chronic liver disease ,medicine.disease ,Virology ,Biochemistry ,digestive system diseases ,Immunopathology ,Monoclonal ,medicine - Abstract
Hepatitis C virus (HCV) infection is found in 80% to 90% of patients with essential mixed cryoglobulinemia (EMC) type II, which is associated with monoclonal IgMk produced by monoclonal B cells. It was investigated whether bcl-2 rearrangement is associated with the clonal B-cell proliferation of EMC induced by hepatitis C. The study groups were composed of 15 patients with HCV and EMC, 12 patients with HCV without EMC, and 7 patients with chronic liver disease (CLD) unrelated to HCV. Fluorescence in situ hybridization with probes was applied to JH and to bcl-2 to study whether JH/bcl-2 translocation was present in these patients. Thirteen of 15 (86%) of patients with HCV-related EMC had the JH/bcl-2 translocation, a significantly higher rate than in HCV patients without EMC (16%; P
- Published
- 2000
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