1. Antibody seronegative human T-lymphotropic virus type III (HTLV-III)- infected patients with acquired immunodeficiency syndrome or related disorders
- Author
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M. G. Sarngadharan, Lawrence N. Shulman, Myron Essex, Saira Salahuddin, Robert C. Gallo, Pamela Hartzband, MF McLane, and Jerome E. Groopman
- Subjects
viruses ,Immunology ,Biochemistry ,Virus ,Antigen ,Acquired immunodeficiency syndrome (AIDS) ,immune system diseases ,hemic and lymphatic diseases ,Medicine ,Arc (protein) ,Leukopenia ,biology ,business.industry ,Viral culture ,virus diseases ,Cell Biology ,Hematology ,biology.organism_classification ,medicine.disease ,Virology ,Deltaretrovirus ,biology.protein ,Antibody ,medicine.symptom ,business - Abstract
The human T-lymphotropic virus type III (HTLV-III) is the primary cause of the acquired immunodeficiency syndrome (AIDS) and related disorders (ARC). Prior studies have reported that nearly all symptomatic patients with AIDS or ARC manifest antibody to HTLV-III. This observation has engendered efforts to screen for HTLV-III, especially prior to blood donation, with assays for antibody to HTLV-III. We report the first two cases, one with AIDS and one with ARC, that are HTLV-III virus positive but antibody negative. Accurate diagnosis of HTLV-III infection in some cases may require direct virus culture or tests for antigen. In addition, lack of HTLV-III antibody may indicate an atypical clinical course of AIDS.
- Published
- 1985