1. Mature T Cells in the Graft Improve NK Cells Reconstitution after Haploidentical Hematopoietic Stem Cell Transplantation
- Author
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Patrice Debré, Stéphanie Nguyen, Jean-Paul Vernant, Mathieu Kuentz, Oualid Bouteraa, Nathalie Dhedin, and Vincent Vieillard
- Subjects
medicine.medical_treatment ,CD3 ,Immunology ,Cell Biology ,Hematology ,Hematopoietic stem cell transplantation ,Biology ,medicine.disease ,Biochemistry ,Transplantation ,Haematopoiesis ,Leukemia ,Cytolysis ,Interleukin 21 ,Graft-versus-host disease ,medicine ,biology.protein - Abstract
We previously demonstrated that natural killer (NK) cells generated after haploidentical stem-cell transplantation (SCT) are blocked at an immature state characterized by phenotypic features and impaired functioning, a blockage that may affect transplantation outcome (Nguyen et al. Blood 2005). Hypothesizing that the absence of mature donor T cells in the graft may affect NK cell differentiation and function, we examined NK cells from 21 patients who received haploidentical SCT from relatives for advanced malignant hematopoietic disease and underwent either partial (pTCD) (CD3+ in the graft >1x105/Kg, mean: 6.9x105/Kg; n=11) or extensive (e-TCD) (CD3+ in the graft
- Published
- 2006