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Your search keyword '"Manenti, Stéphane"' showing total 11 results
Start Over Author "Manenti, Stéphane" Publisher american society of hematology
11 results on '"Manenti, Stéphane"'

1. PIM2 kinase has a pivotal role in plasmablast generation and plasma cell survival, opening up novel treatment options in myeloma

Author

Haas, Marion, primary, Caron, Gersende, additional, Chatonnet, Fabrice, additional, Manenti, Stéphane, additional, Alaterre, Elina, additional, Devin, Julie, additional, Delaloy, Céline, additional, Bertolin, Giulia, additional, Viel, Roselyne, additional, Pignarre, Amandine, additional, Llamas-Gutierrez, Francisco, additional, Marchalot, Anne, additional, Decaux, Olivier, additional, Tarte, Karin, additional, Delpy, Laurent, additional, Moreaux, Jérôme, additional, and Fest, Thierry, additional

Published
2022
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2. Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

Author

Larrue, Clément, primary, Saland, Estelle, additional, Boutzen, Héléna, additional, Vergez, François, additional, David, Marion, additional, Joffre, Carine, additional, Hospital, Marie-Anne, additional, Tamburini, Jérôme, additional, Delabesse, Eric, additional, Manenti, Stéphane, additional, Sarry, Jean Emmanuel, additional, and Récher, Christian, additional

Published
2016
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3. Cytosine Arabinoside Chemotherapy Does Not Enrich For Leukemic Stem Cells In Xenotransplantation Model Of Human Acute Myeloid Leukemia

Author

de Toni, Fabienne, primary, Perry, Robin L., additional, Saland, Estelle, additional, Sugita, Mayumi, additional, David, Marion, additional, Vergez, François, additional, Delabesse, Eric, additional, De Mas Mansat, Véronique, additional, Demur, Cécile, additional, Iacovoni, Jason, additional, Manenti, Stéphane, additional, Danet-Desnoyers, Gwenn, additional, Recher, Christian, additional, Carroll, Martin, additional, and Sarry, Jean-Emmanuel, additional

Published
2013
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4. Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Author

Thomas, Daniel, primary, Powell, Jason A., additional, Vergez, Francois, additional, Segal, David H., additional, Nguyen, Nhu-Y. N., additional, Baker, Adele, additional, Teh, Tse-Chieh, additional, Barry, Emma F., additional, Sarry, Jean-Emmanuel, additional, Lee, Erwin M., additional, Nero, Tracy L., additional, Jabbour, Anissa M., additional, Pomilio, Giovanna, additional, Green, Benjamin D., additional, Manenti, Stéphane, additional, Glaser, Stefan P., additional, Parker, Michael W., additional, Lopez, Angel F., additional, Ekert, Paul G., additional, Lock, Richard B., additional, Huang, David C. S., additional, Nilsson, Susie K., additional, Récher, Christian, additional, Wei, Andrew H., additional, and Guthridge, Mark A., additional

Published
2013
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5. The cell cycle regulator CDC25A is a target for JAK2V617F oncogene

Author

Gautier, Emilie-Fleur, primary, Picard, Muriel, additional, Laurent, Camille, additional, Marty, Caroline, additional, Villeval, Jean-Luc, additional, Demur, Cécile, additional, Delhommeau, François, additional, Hexner, Elizabeth, additional, Giraudier, Stéphane, additional, Bonnevialle, Nicolas, additional, Ducommun, Bernard, additional, Récher, Christian, additional, Laurent, Guy, additional, Manenti, Stéphane, additional, and Mansat-De Mas, Véronique, additional

Published
2012
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6. The Cell Cycle Regulator CDC25A Is a Target for JAK2V617F Oncogene

Author

Gautier, Emilie-Fleur, primary, Recher, Christian, additional, Laurent, Camille, additional, Marty, Caroline, additional, Villeval, Jean-Luc, additional, Demur, Cécile, additional, Delhommeau, Francois, additional, Hexner, Elizabeth, additional, Giraudier, Stephane, additional, Bonnevialle, Nicolas, additional, Ducommun, Bernard, additional, Laurent, Guy, additional, Manenti, Stéphane, additional, and Mansat- De Mas, Véronique, additional

Published
2011
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7. Metabolic Capability to Induce the Pasteur Effect Mediates Sensitivity of Human Leukemic Cells to Metformin

Author

Scotland, Sarah, primary, Saland, Estelle, additional, Peyriga, Lindsay, additional, Peyraud, Rémi, additional, Micklow, Elizabeth, additional, Danet-Desnoyers, Gwenn, additional, Manenti, Stéphane, additional, Récher, Christian, additional, Portais, Jean-Charles, additional, Selak, Mary, additional, Carroll, Martin, additional, and Sarry, Jean-Emmanuel, additional

Published
2011
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8. Prognostic Impact of the Amount of CD34+ CD38- CD123+ Cells at Diagnosis In Acute Myeloid Leukemia: a Study From the GOELAMS

Author

Vergez, François, primary, Green, Alexa, additional, Tamburini, Jérôme, additional, Gallay, Nathalie, additional, Roussel, Murielle, additional, Gaillard, Baptiste, additional, Neyret, Aymeric, additional, Pannetier, Melanie, additional, Chapuis, Nicolas, additional, Ifrah, Norbert, additional, Dreyfus, Francois, additional, Demur, Cécile, additional, Lacombe, Catherine, additional, Mayeux, Patrick, additional, Bouscary, Didier, additional, Manenti, Stéphane, additional, Récher, Christian, additional, and Bardet, Valérie, additional

Published
2010
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9. Anti-Leukemic Activity of PIK-75, a PI3-Kinase p110α Selective Inhibitor, In Acute Myeloid Leukemia

Author

Vergez, François, primary, Sarry, Jean-Emmanuel, additional, Gallay, Nathalie, additional, Fialin, Camille, additional, Scotland, Sarah, additional, Demur, Cécile, additional, Shepherd, Peter, additional, Danet-Desnoyer, Gwenn-ael, additional, Kruczynski, Anna, additional, Payrastre, Bernard, additional, Manenti, Stéphane, additional, and Recher, Christian, additional

Published
2010
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11. The cell cycle regulator CDC25A is a target for JAK2V617F oncogene.

Author

Gautier, Emilie-Fleur, Picard, Muriel, Laurent, Camille, Marty, Caroline, Villeval, Jean-Luc, Demur, Cécile, Delhommeau, François, Hexner, Elizabeth, Giraudier, Stéphane, Bonnevialle, Nicolas, Ducommun, Bernard, Récher, Christian, Laurent, Guy, Manenti, Stéphane, and Mansat-De Mas, Véronique

Subjects
*CELLULAR control mechanisms, *SOMATIC mutation, *ONCOGENES, *TARGETED drug delivery, *POLYCYTHEMIA vera, *PATIENTS
Abstract

The JAK2V617F mutation is present in the majority of polycythemia vera patients and half of those with essential thrombocythemia and primary myelofibrosis. JAK2V617F is a gain-of-function mutation resulting in constitutive JAK2 signalling involved in the pathogenesis of these diseases. JAK2V617F has been shown to promote S phase entry. Here, we demonstrate that the CDC25A phosphatase, a key regulator of the G1/S cell cycle transition, is constitutively over-expressed in JAK2V617F-positive cell lines, JAK2-mutated patient CD36+ progenitors, and in vitro differentiated proerythroblasts. Accordingly, CDC25A is over-expressed in bone marrow and spleen of Jak2V617F knock-in mice compared to wild-type littermates. Using murine FDC-P1-EPOR and human HEL and SET-2 cell lines, we found that JAK2V617F-induced CDC25A up-regulation was caused neither by increased CDC25A transcription or stability, nor by the involvement of its upstream regulators Akt and MAPK. Instead, our results suggest that CDC25A is regulated at the translational level through STAT5 and the translational initiation factor eIF2α CDC25A inhibition reduces the clonogenic and proliferative potential of JAK2V617F-expressing cell lines and erythroid progenitors, while moderately affecting normal erythroid differentiation. These results suggest that CDC25A deregulation may be involved in hematopoietic cells expansion in JAK2V617F patients making of this protein an attracting potential therapeutic target. [ABSTRACT FROM AUTHOR]

Published
2012
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