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Start Over Author "Ma, Yussanne" Publisher american society of hematology
19 results on '"Ma, Yussanne"'

1. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma

Author

Grande, Bruno M., primary, Gerhard, Daniela S., additional, Jiang, Aixiang, additional, Griner, Nicholas B., additional, Abramson, Jeremy S., additional, Alexander, Thomas B., additional, Allen, Hilary, additional, Ayers, Leona W., additional, Bethony, Jeffrey M., additional, Bhatia, Kishor, additional, Bowen, Jay, additional, Casper, Corey, additional, Choi, John Kim, additional, Culibrk, Luka, additional, Davidsen, Tanja M., additional, Dyer, Maureen A., additional, Gastier-Foster, Julie M., additional, Gesuwan, Patee, additional, Greiner, Timothy C., additional, Gross, Thomas G., additional, Hanf, Benjamin, additional, Harris, Nancy Lee, additional, He, Yiwen, additional, Irvin, John D., additional, Jaffe, Elaine S., additional, Jones, Steven J. M., additional, Kerchan, Patrick, additional, Knoetze, Nicole, additional, Leal, Fabio E., additional, Lichtenberg, Tara M., additional, Ma, Yussanne, additional, Martin, Jean Paul, additional, Martin, Marie-Reine, additional, Mbulaiteye, Sam M., additional, Mullighan, Charles G., additional, Mungall, Andrew J., additional, Namirembe, Constance, additional, Novik, Karen, additional, Noy, Ariela, additional, Ogwang, Martin D., additional, Omoding, Abraham, additional, Orem, Jackson, additional, Reynolds, Steven J., additional, Rushton, Christopher K., additional, Sandlund, John T., additional, Schmitz, Roland, additional, Taylor, Cynthia, additional, Wilson, Wyndham H., additional, Wright, George W., additional, Zhao, Eric Y., additional, Marra, Marco A., additional, Morin, Ryan D., additional, and Staudt, Louis M., additional

Published
2019
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2. Marked Differences in the Genomic Landscape of Pediatric Compared to Adult Acute Myeloid Leukemia: A Report from the Children's Oncology Group and NCI/COG Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative

Author

Farrar, Jason E, primary, Bolouri, Hamid, additional, Ries, Rhonda E., additional, Triche, Timothy Junius, additional, Lim, Emilia L., additional, Alonzo, Todd A., additional, Ma, Yussanne, additional, Moore, Richard, additional, Mungall, Andrew J., additional, Marra, Marco A., additional, Auvil, Jaime Guidry, additional, Davidsen, Tanja M., additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, Smith, Malcolm A., additional, Gerhard, Daniela S., additional, and Meshinchi, Soheil, additional

Published
2016
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3. Alteration of Chromatin Modifiers and Misregulation of Transcription Factors Define the Genomic Profile of Infant AML

Author

Ries, Rhonda E., primary, Bolouri, Hamid, additional, Farrar, Jason E, additional, Lim, Emilia L., additional, Triche, Timothy Junius, additional, Tarlock, Katherine, additional, Auvil, Jaime Guidry, additional, Hirsch, Betsy A., additional, Raimondi, Susana C., additional, Ma, Yussanne, additional, Marra, Marco A., additional, Aplenc, Richard, additional, Guest, Erin M., additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, Smith, Malcolm A., additional, Gerhard, Daniela S., additional, and Meshinchi, Soheil, additional

Published
2016
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4. Genomic Landscape of Pediatric Mixed Phenotype Acute Leukemia

Author

Alexander, Thomas B., primary, Gu, Zhaohui, additional, Choi, John K, additional, Loh, Mignon L., additional, Horan, John, additional, Buldini, Barbara, additional, Basso, Giuseppe, additional, Elitzur, Sarah, additional, Zwaan, C. Michel, additional, de Haas, Valerie, additional, Yeoh, Allen Eng Juh, additional, Reinhardt, Dirk, additional, Tomizawa, Daisuke, additional, Lammens, Tim, additional, De Moerloose, Barbara, additional, Zhou, Li, additional, Hori, Hiroki, additional, Moorman, Anthony V., additional, Moore, Andrew S., additional, Hrusak, Ondrej, additional, Meshinchi, Soheil, additional, Orgel, Etan, additional, Devidas, Meenakshi, additional, Hunger, Stephen P., additional, Guidry Auvil, Jamie M, additional, Smith, Malcolm A., additional, Davidsen, Tanja M., additional, Hermida, Leandro C., additional, Gesuwan, Patee, additional, Marra, Marco A., additional, Ma, Yussanne, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Gerhard, Daniela S., additional, Cao, Xueyuan, additional, Shi, Lei, additional, Pounds, Stanley, additional, Inaba, Hiroto, additional, and Mullighan, Charles, additional

Published
2016
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5. A microRNA Expression-Based Model Predicts Event Free Survival in Pediatric Acute Myeloid Leukemia

Author

Lim, Emilia L., primary, Trinh, Diane L., additional, Ries, Rhonda E., additional, Wang, Jim, additional, Ma, Yussanne, additional, Topham, James, additional, Hughes, Maya D., additional, Pleasance, Erin, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Zhao, Yongjun, additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, Gerhard, Daniela S., additional, Alonzo, Todd A., additional, Meshinchi, Soheil, additional, and Marra, Marco A., additional

Published
2016
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6. Divergent Epigenomes in Pediatric and Adult Acute Myeloid Leukemia Implicate Cell of Origin and Transcriptional Silencing of Immune Responses As Sources of Clinically Relevant Heterogeneity: A Report from the Children's Oncology Group and NCI/COG Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative

Author

Triche, Timothy Junius, primary, Farrar, Jason E, additional, Bolouri, Hamid, additional, Ries, Rhonda E., additional, Lim, Emilia L., additional, Alonzo, Todd A., additional, Ma, Yussanne, additional, Moore, Richard, additional, Mungall, Andrew J., additional, Marra, Marco A., additional, Guidry Auvil, Jaime M., additional, Davidsen, Tanja M., additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Kolb, E. Anders, additional, Gamis, Alan, additional, Smith, Malcolm A., additional, Piccolo, Stephen R, additional, Gerhard, Daniela S, additional, and Meshinchi, Soheil, additional

Published
2016
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7. Burkitt Lymphoma Genome Sequencing Project (BLGSP): Introduction

Author

Gerhard, Daniela S, primary, Grande, Bruno, additional, Griner, Nicholas, additional, Casper, Corey, additional, Gerdts, Sarah E., additional, Omoding, Abraham, additional, Orem, Jackson, additional, Mbulaiteye, Sam M, additional, Ogwang, Martin D., additional, Reynolds, Steven J., additional, Bhatia, Kishor, additional, Ayers, Leona, additional, Choi, John K, additional, Mullighan, Charles G., additional, Sandlund, John T., additional, Alexander, Thomas B., additional, Abramson, Jeremy S., additional, Gross, Thomas G., additional, Noy, Ariela, additional, Bethony, Jeffrey, additional, Leal, Fabio, additional, Greiner, Timothy C, additional, Jaffe, Elaine S., additional, Harris, Nancy Lee, additional, Gastier-Foster, Julie M., additional, Bowen, Jay, additional, Hanf, Benjamin, additional, Schmitz, Roland, additional, Martin, Jean-Paul, additional, Martin, Marie-Reine, additional, Irvin, John D., additional, Miller, Ellen, additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Davidsen, Tanja M., additional, Mungall, Andrew J., additional, Ma, Yussanne, additional, Marra, Marco A., additional, Morin, Ryan D., additional, and Staudt, Louis M., additional

Published
2016
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8. Discovery and Validation of Cell-Surface Protein Mesothelin (MSLN) As a Novel Therapeutic Target in AML: Results from the COG/NCI Target AML Initiative

Author

Tarlock, Katherine, primary, Kaeding, Allison J., additional, Alonzo, Todd A., additional, Loken, Michael R., additional, Ries, Rhonda E., additional, Pardo, Laura, additional, Gerbing, Robert, additional, Farrar, Jason E, additional, Guidry Auvil, Jaime M., additional, Gerhard, Daniela S., additional, Smith, Malcolm A., additional, Davidsen, Tanja M., additional, Gesuwan, Pattee, additional, Hermida, Leandro C., additional, Marra, Marco A., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Ma, Yussanne, additional, Zong, Stuart, additional, Long, William, additional, Gamis, Alan S., additional, Kolb, E. Anders, additional, and Meshinchi, Soheil, additional

Published
2016
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9. CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML

Author

Maxson, Julia E., primary, Ries, Rhonda E., additional, Wang, Yi-Cheng, additional, Gerbing, Robert B., additional, Kolb, E. Anders, additional, Thompson, Sarah L., additional, Guidry Auvil, Jaime M., additional, Marra, Marco A., additional, Ma, Yussanne, additional, Zong, Zusheng, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Long, William, additional, Gesuwan, Patee, additional, Davidsen, Tanja M., additional, Hermida, Leandro C., additional, Hughes, Seamus B., additional, Farrar, Jason E., additional, Radich, Jerald P., additional, Smith, Malcolm A., additional, Gerhard, Daniela S., additional, Gamis, Alan S., additional, Alonzo, Todd A., additional, and Meshinchi, Soheil, additional

Published
2016
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10. Comprehensive Sequence Analysis of Relapse and Refractory Pediatric Acute Myeloid Leukemia Identifies miRNA and mRNA Transcripts Associated with Treatment Resistance - a Report from the COG/NCI-Target AML Initiative

Author

Lim, Emilia L., primary, Trinh, Diane L., additional, Ries, Rhonda E., additional, Ma, Yussanne, additional, Topham, James, additional, Hughes, Maya D., additional, Pleasance, Erin, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Zhao, Yongjun, additional, Gerhard, Daniela S., additional, Oehler, Vivian, additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, Smith, Malcolm A., additional, Alonzo, Todd A., additional, Arceci, Robert J., additional, Meshinchi, Soheil, additional, and Marra, Marco A., additional

Published
2015
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11. TET2 Mutations Are Highly Associated with RUNX1-RUNX1T1 Translocations and NPMc+ in Childhood AML: a Report from Children's Oncology Group AAML03P1, AAML0531 and NCI/COG Target AML Initiative

Author

Kutny, Matthew A., primary, Alonzo, Todd A., additional, Wang, Yi-Cheng, additional, Ries, Rhonda, additional, Farrar, Jason E., additional, Guidry Auvil, Jaime M., additional, Smith, Malcolm A., additional, Gerhard, Daniela S., additional, Davidsen, Tanja M., additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Marra, Marco A, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Long, William, additional, Ma, Yussanne, additional, Zong, Stuart, additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, and Meshinchi, Soheil, additional

Published
2015
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12. ASXL1 and ASXL2 Mutations in Childhood AML Are Strongly Associated with t(8;21) but Do Not Independently Impact on Prognosis: A Report from the Children's Oncology Group and NCI/COG Target Initiative

Author

Farrar, Jason E., primary, Alonzo, Todd A., additional, Ries, Rhonda E., additional, Gerbing, Robert B., additional, Guidry Auvil, Jaime M., additional, Davidsen, Tanja M., additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Marra, Marco A, additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Ma, Yussanne, additional, Long, William, additional, Zong, Stuart, additional, Kolb, E. Anders, additional, Smith, Malcolm A., additional, Gerhard, Daniela S., additional, Gamis, Alan S., additional, and Meshinchi, Soheil, additional

Published
2015
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13. CSF3R Mutations Represent a Novel Therapeutic Target in Pediatric AML with a High Degree of Overlap with CEBPA Mutations: a Report from COG AAML0531 and COG/NCI Target AML Initiative

Author

Maxson, Julia Elizabeth, primary, Ries, Rhonda, additional, Wang, Yi-Cheng, additional, Gerbing, Robert B., additional, Kolb, E. Anders, additional, Thompson, Sarah L, additional, Guidry Auvil, Jaime M., additional, Marra, Marco A, additional, Ma, Yussanne, additional, Zong, Stuart, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Long, William, additional, Gesuwan, Patee, additional, Davidsen, Tanja M., additional, Hermida, Leandro C., additional, Farrar, Jason E., additional, Radich, Jerald P., additional, Smith, Malcolm A., additional, Gerhard, Daniela S., additional, Gamis, Alan S., additional, Alonzo, Todd A., additional, and Meshinchi, Soheil, additional

Published
2015
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14. Comprehensive Genomic and Transcript Profiling of CBL Gene in Childhood AML: A Report from Children's Oncology Group Studies AAML03P1, AAML0531 and COG/NCI Target AML Initiative

Author

Chin, Diana, primary, Kutny, Matthew A., additional, Grim, Jonathan, additional, Gerbing, Robert B., additional, Miller, Kristen, additional, Farrar, Jason E., additional, Guidry Auvil, Jaime M., additional, Smith, Malcolm A., additional, Gerhard, Daniela S., additional, Davidsen, Tanja M., additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Marra, Marco A, additional, Mungall, Andrew J., additional, Moore, Richard, additional, Long, William, additional, Ma, Yussanne, additional, Zong, Stuart, additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, Alonzo, Todd A., additional, and Meshinchi, Soheil, additional

Published
2015
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15. Discovery and Functional Validation of Novel Pediatric Specific FLT3 Activating Mutations in Acute Myeloid Leukemia: Results from the COG/NCI Target Initiative

Author

Tarlock, Katherine, primary, Hansen, M. Eva, additional, Hylkema, Tiffany, additional, Ries, Rhonda, additional, Farrar, Jason E., additional, Auvil, Jaime Guidry, additional, Gerhard, Daniela S., additional, Smith, Malcolm A., additional, Davidsen, Tanja M., additional, Gesuwan, Patee, additional, Hermida, Leandro C., additional, Marra, Marco A, additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Ma, Yussanne, additional, Zong, Stuart, additional, Long, William, additional, Boggon, Titus, additional, Alonzo, Todd A., additional, Kolb, E. Anders, additional, Gamis, Alan S., additional, and Meshinchi, Soheil, additional

Published
2015
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16. Rearrangements in Nucleoporin Family of Genes in Childhood Acute Myeloid Leukemia: A Report from Children Oncology Group and NCI/COG Target AML Initiative

Author

Leandro C. Hermida, Fabiana Ostronoff, Alan S. Gamis, Marco A. Marra, Jason E. Farrar, Tanja M. Davidsen, Soheil Meshinchi, Jaime M. Guidry Auvil, Daniela S. Gerhard, E. Anders Kolb, Betsy A. Hirsch, William Long, Gesuwan Patee, Andrew Andrew, Stuart Zong, Rhonda E. Ries, Karen Mungall, Todd A. Alonzo, Malcolm A. Smith, Ma Yussanne, Susana C. Raimondi, and Robert B. Gerbing

Subjects
Oncology, medicine.medical_specialty, NPM1, Myeloid, Immunology, Childhood Acute Myeloid Leukemia, Myeloid leukemia, Karyotype, Cell Biology, Hematology, Biology, Core binding factor, Biochemistry, Minimal residual disease, medicine.anatomical_structure, hemic and lymphatic diseases, Internal medicine, CEBPA, medicine
Abstract

Genetic alterations in the Nucleoporin (NUP) family of genes are involved in myeloid leukemogenesis and are associated with poor prognosis. We previously showed that NUP98-NSD1 is prevalent in acute myeloid leukemia (AML) and is highly associated with FLT3-ITD and dismal outcome. As genetic alterations in the NUP family are frequently cryptic by conventional karyotyping, their incidence has been underestimated. The COG/NCI TARGET AML initiative has performed comprehensive genome-wide characterization of diagnostic specimens from 200 pediatric AML cases in order to identify novel genetic lesions with prognostic and therapeutic significance. The interrogation of the whole genome and RNA sequencing data generated by this initiative identified numerous fusion transcripts involving the NUP family of genes, including NUP98-NSD1, NUP98-KDM5A, NUP98-HOXA9, NUP98-HMG3, NUP98-HOXD13, NUP98-PHF23, NUP98-BRWD3, CLINT-NUP98 and DEK-NUP214. All computationally identified NUP fusions were verified by orthogonal methodology and high-throughput screening assay was developed for frequency determination. The verified NUP fusions were screened in children treated on COG AAML0531 and AAML03P1 to define their prevalence, clinical characteristics and association with clinical outcome. The impact of NUP fusions was initially evaluated in patients with cytogenetically normal AML (CN-AML). NUP fusions were observed in 14.5% (35 of 242) patients: NUP98-NSD1 (N=21), DEK-NUP214 (N=3), NUP98-HMG3 (N=3), NUP98-HOXD13 (N=2), NUP98-PHF23 (N=2) and NUP98-KDM5A (N=4). The NUP fusions NUP98-BRWD3, NUP98-HOXA9 and CLINT-NUP98 were not found in CN-AML patients. Demographics and disease characteristics of CN-AML patients with and without NUP fusions were compared. Although patients of Asian descent comprised only 7% of the study population, they harbored significantly higher number of NUP fusions (29% vs 5%, P =0.002). Among those of Asian descent with CN-AML, 35% harbored a NUP fusion. We also noted an inverse association between NUP fusions and African-Americans where NUP fusions were not identified in any of African-American patients (P =0.031). NUP fusions were correlated with other common mutations in AML. NPM1 (9% vs 28%, P =0.007) and CEBPA (6% vs 19%, P =0.06) were rare in patients with NUP fusions, whereas FLT3/ITD (62% vs 34%, P =0.002) and WT1 (32% vs 8%, P Given the high co-occurrence of NUP fusions and FLT3-ITD, we investigated the prevalence and clinical correlation of NUP fusions in all FLT3-ITD-positive patients. The prevalence of NUP fusions in FLT3-ITD patients was 26% (43 of 164). The CR rate was lower in patients co-expressing the NUP fusion and FLT3-ITD (40% vs 71%, P In this study we report on the discovery, verification and frequency validation of NUP fusions, a new class of genetic alterations in AML. We demonstrate that NUP fusionsare common in pediatric patients and patients with CN-AML harboring NUP fusions have poor outcome and are more likely to have post-induction MRD than those without thesefusions. Furthermore, there is a high co-occurrence of FLT3-ITD and NUP fusions and patients harboring both genetic lesions have a lower CR rate and high post-induction MRD than those with FLT3-ITD alone. NUP fusions define a new subgroup of pediatric AML patients with an overall poor prognosis. AML harboring NUP fusions likely share similar mechanisms of leukemogenesis and targeting these genetic lesions will likely improve outcome in a significant subset of pediatric AML patients. Disclosures No relevant conflicts of interest to declare.

Published
2015
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17. Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype

Author

Migliorini, Gabriele, primary, Fiege, Bettina, additional, Hosking, Fay J., additional, Ma, Yussanne, additional, Kumar, Rajiv, additional, Sherborne, Amy L., additional, da Silva Filho, Miguel Inacio, additional, Vijayakrishnan, Jayaram, additional, Koehler, Rolf, additional, Thomsen, Hauke, additional, Irving, Julie A., additional, Allan, James M., additional, Lightfoot, Tracy, additional, Roman, Eve, additional, Kinsey, Sally E., additional, Sheridan, Eamonn, additional, Thompson, Pamela, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Mühleisen, Thomas W., additional, Eisele, Lewin, additional, Zimmermann, Martin, additional, Bartram, Claus R., additional, Schrappe, Martin, additional, Greaves, Mel, additional, Stanulla, Martin, additional, Hemminki, Kari, additional, and Houlston, Richard S., additional

Published
2013
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18. FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma

Author

Ma, Yussanne P., primary, van Leeuwen, Flora E., additional, Cooke, Rosie, additional, Broeks, Annegien, additional, Enciso-Mora, Victor, additional, Olver, Bianca, additional, Lloyd, Amy, additional, Broderick, Peter, additional, Russell, Nicola S., additional, Janus, Cecile, additional, Ashworth, Alan, additional, Houlston, Richard S., additional, and Swerdlow, Anthony J., additional

Published
2012
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19. Multiple Hodgkin lymphoma–associated loci within the HLA region at chromosome 6p21.3

Author

Moutsianas, Loukas, primary, Enciso-Mora, Victor, additional, Ma, Yussanne P., additional, Leslie, Stephen, additional, Dilthey, Alexander, additional, Broderick, Peter, additional, Sherborne, Amy, additional, Cooke, Rosie, additional, Ashworth, Alan, additional, Swerdlow, Anthony J., additional, McVean, Gilean, additional, and Houlston, Richard S., additional

Published
2011
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