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Start Over Author "Lutz, Patrick" Publisher american society of hematology
35 results on '"Lutz, Patrick"'

1. Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation

Author

Gluckman, Eliane, primary, Cappelli, Barbara, additional, Bernaudin, Francoise, additional, Labopin, Myriam, additional, Volt, Fernanda, additional, Carreras, Jeanette, additional, Pinto Simões, Belinda, additional, Ferster, Alina, additional, Dupont, Sophie, additional, de la Fuente, Josu, additional, Dalle, Jean-Hugues, additional, Zecca, Marco, additional, Walters, Mark C., additional, Krishnamurti, Lakshmanan, additional, Bhatia, Monica, additional, Leung, Kathryn, additional, Yanik, Gregory, additional, Kurtzberg, Joanne, additional, Dhedin, Nathalie, additional, Kuentz, Mathieu, additional, Michel, Gerard, additional, Apperley, Jane, additional, Lutz, Patrick, additional, Neven, Bénédicte, additional, Bertrand, Yves, additional, Vannier, Jean Pierre, additional, Ayas, Mouhab, additional, Cavazzana, Marina, additional, Matthes-Martin, Susanne, additional, Rocha, Vanderson, additional, Elayoubi, Hanadi, additional, Kenzey, Chantal, additional, Bader, Peter, additional, Locatelli, Franco, additional, Ruggeri, Annalisa, additional, and Eapen, Mary, additional

Published
2017
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2. Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation.

Author

UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Gluckman, Eliane, Cappelli, Barbara, Bernaudin, Francoise, Labopin, Myriam, Volt, Fernanda, Carreras, Jeanette, Pinto Simões, Belinda, Ferster, Alina, Dupont, Sophie, de la Fuente, Josu, Dalle, Jean-Hugues, Zecca, Marco, Walters, Mark C, Krishnamurti, Lakshmanan, Bhatia, Monica, Leung, Kathryn, Yanik, Gregory, Kurtzberg, Joanne, Dhedin, Nathalie, Kuentz, Mathieu, Michel, Gerard, Apperley, Jane, Lutz, Patrick, Neven, Bénédicte, Bertrand, Yves, Vannier, Jean Pierre, Ayas, Mouhab, Cavazzana, Marina, Matthes-Martin, Susanne, Rocha, Vanderson, Elayoubi, Hanadi, Kenzey, Chantal, Bader, Peter, Locatelli, Franco, Ruggeri, Annalisa, Eapen, Mary, Eurocord, the Pediatric Working Party of the European Society for Blood and Marrow Transplantation, Center for International Blood and Marrow Transplant Research, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique, Gluckman, Eliane, Cappelli, Barbara, Bernaudin, Francoise, Labopin, Myriam, Volt, Fernanda, Carreras, Jeanette, Pinto Simões, Belinda, Ferster, Alina, Dupont, Sophie, de la Fuente, Josu, Dalle, Jean-Hugues, Zecca, Marco, Walters, Mark C, Krishnamurti, Lakshmanan, Bhatia, Monica, Leung, Kathryn, Yanik, Gregory, Kurtzberg, Joanne, Dhedin, Nathalie, Kuentz, Mathieu, Michel, Gerard, Apperley, Jane, Lutz, Patrick, Neven, Bénédicte, Bertrand, Yves, Vannier, Jean Pierre, Ayas, Mouhab, Cavazzana, Marina, Matthes-Martin, Susanne, Rocha, Vanderson, Elayoubi, Hanadi, Kenzey, Chantal, Bader, Peter, Locatelli, Franco, Ruggeri, Annalisa, Eapen, Mary, Eurocord, the Pediatric Working Party of the European Society for Blood and Marrow Transplantation, and Center for International Blood and Marrow Transplant Research

Abstract

Despite advances in supportive therapy to prevent complications of sickle cell disease (SCD), access to care is not universal. Hematopoietic cell transplantation is, to date, the only curative therapy for SCD, but its application is limited by availability of a suitable HLA-matched donor and lack of awareness of the benefits of transplant. Included in this study are 1000 recipients of HLA-identical sibling transplants performed between 1986 and 2013 and reported to the European Society for Blood and Marrow Transplantation, Eurocord, and the Center for International Blood and Marrow Transplant Research. The primary endpoint was event-free survival, defined as being alive without graft failure; risk factors were studied using a Cox regression models. The median age at transplantation was 9 years, and the median follow-up was longer than 5 years. Most patients received a myeloablative conditioning regimen (n = 873; 87%); the remainder received reduced-intensity conditioning regimens (n = 125; 13%). Bone marrow was the predominant stem cell source (n = 839; 84%); peripheral blood and cord blood progenitors were used in 73 (7%) and 88 (9%) patients, respectively. The 5-year event-free survival and overall survival were 91.4% (95% confidence interval, 89.6%-93.3%) and 92.9% (95% confidence interval, 91.1%-94.6%), respectively. Event-free survival was lower with increasing age at transplantation (hazard ratio [HR], 1.09; < .001) and higher for transplantations performed after 2006 (HR, 0.95; = .013). Twenty-three patients experienced graft failure, and 70 patients (7%) died, with the most common cause of death being infection. The excellent outcome of a cohort transplanted over the course of 3 decades confirms the role of HLA-identical sibling transplantation for children and adults with SCD.

Published
2017

3. Prophylactic CNS Therapy (with or without Radiation Therapy) in Medium-High Risk Acute Lymphoblastic Leukemia (ALL) Children: Long-Term Outcome Evaluation of the Randomized BFM-Oriented Trial 58832 (period 1983-1989) of the EORTC Children Leukemia Group

Author

Piette, Caroline, primary, Suciu, Stefan, additional, Bertrand, Yves, additional, Uyttebroeck, Anne, additional, Vandecruys, Els, additional, Plat, Geneviève, additional, Lutz, Patrick, additional, Pluchart, Claire, additional, Sirvent, Nicolas, additional, Poirée, Maryline, additional, Simon, Pauline, additional, Ferster, Alina, additional, Hoyoux, Claire, additional, Mazingue, Francoise, additional, Paulus, Robert, additional, Plantaz, Dominique, additional, Thomas, Caroline, additional, Gilotay, Caroline, additional, Van Der Werff Ten Bosch, Jutte, additional, Rohrlich, Pierre Simon, additional, and Benoit, Yves, additional

Published
2016
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4. Late Effects in Survivors of Infantile Acute Leukemia Are Less Severe Than Expected: A Study of the L.E.a Program

Author

Gandemer, Virginie, primary, Bonneau, Jacinthe, additional, Oudin, Caroline, additional, Berbis, Julie, additional, Bertrand, Yves, additional, Tabone, Marie-Dominique, additional, Ducassou, Stephane, additional, Chastagner, Pascal, additional, Brethon, Benoit, additional, Dalle, Jean-Hugues, additional, Thouvenin, Sandrine, additional, Poiree, Maryline, additional, Plantaz, Dominique, additional, Kanold, Justyna, additional, Sirvent, Nicolas, additional, Lutz, Patrick, additional, Hamidou, Zeinab, additional, Baruchel, Andre, additional, Leverger, Guy, additional, Auquier, Pascal, additional, and Michel, Gerard, additional

Published
2016
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5. Metabolic Syndrome in Long-Term Survivors of Childhood Acute Leukemia Treated without Hematopoietic Stem Cell Transplantation: An L.E.Α. Study

Author

Saultier, Paul, primary, Auquier, Pascal, additional, Bertrand, Yves, additional, Vercasson, Camille, additional, Oudin, Claire, additional, Contet, Audrey, additional, Plantaz, Dominique, additional, Poirée, Marilyne, additional, Ducassou, Stéphane, additional, Kanold, Justyna, additional, Tabone, Marie-Dominique, additional, Dalle, Jean-Hugues, additional, Lutz, Patrick, additional, Gandemer, Virginie, additional, Sirvent, Nicolas, additional, Thouvenin, Sandrine, additional, Berbis, Julie, additional, Chambost, Hervé, additional, Baruchel, André, additional, Leverger, Guy, additional, and Michel, Gérard, additional

Published
2016
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6. Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndrome

Author

Michel, Gérard, primary, Galambrun, Claire, additional, Sirvent, Anne, additional, Pochon, Cecile, additional, Bruno, Benedicte, additional, Jubert, Charlotte, additional, Loundou, Anderson, additional, Yakoub-Agha, Ibrahim, additional, Milpied, Noel, additional, Lutz, Patrick, additional, Marie-Cardine, Aude, additional, Gandemer, Virginie, additional, Blaise, Didier, additional, Michallet, Mauricette, additional, Rialland, Fanny, additional, Renard, Cecile, additional, Oudin, Claire, additional, Esmiol, Sophie, additional, Seux, Mylene, additional, Baumstarck, Karine, additional, Mohty, Mohamad, additional, Rocha, Vanderson, additional, and Dalle, Jean-Hugues, additional

Published
2016
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7. t(12;21)/ETV6 -RUNX1 Confers a Specific Pattern of In Vivo Sensitivity to Treatments in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL): Results of the Randomized Trials 58881 and 58951 of the EORTC Children Leukemia Group

Author

Piette, Caroline, primary, Suciu, Stefan, additional, Clappier, Emmanuelle, additional, Bertrand, Yves, additional, Plat, Genevieve, additional, Chantrain, Christophe, additional, Costa, Vitor, additional, Dastugue, Nicole, additional, Ferster, Alina, additional, Gilotay, Caroline, additional, Girard, Sandrine, additional, Grardel, Nathalie, additional, Lutz, Patrick, additional, Mazingue, Francoise, additional, Minckes, Odile, additional, Munzer, Martine, additional, Plouvier, Emmanuel, additional, Sirvent, Nicolas, additional, Uyttebroeck, Anne, additional, van Roy, Nadine, additional, Yakouben, Karima, additional, Benoit, Yves, additional, and Cavé, Hélène, additional

Published
2015
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8. Hematopoietic Stem Cell Transplantation from HLA Identical Sibling Forsickle Cell Disease an International Survey on Behalf of Eurocord-Monacord, EBMT Paediatric Disease Working Party and CIBMTR

Author

Cappelli, Barbara, primary, Bernaudin, Francoise, additional, Ruggeri, Annalisa, additional, Labopin, Myriam, additional, Volt, Fernanda, additional, Simoes, Belinda Pinto, additional, Ferster, Alina, additional, Dupont, Sophie, additional, de la Fuente, Josu, additional, Dalle, Jean-Hugues, additional, Zecca, Marco, additional, Robin, Marie, additional, Walters, Mark C., additional, Dhedin, Nathalie, additional, Michel, Gerard, additional, Lutz, Patrick, additional, Neven, Benedicte, additional, Bertrand, Yves, additional, Vannier, Jean Pierre, additional, Ayas, Mouhab, additional, Matthes, Susanne, additional, Elayoubi, Hanadi, additional, Devergie, Agnes, additional, Kenzey, Chantal, additional, Locatelli, Franco, additional, Peters, Christina, additional, Rocha, Vanderson, additional, Eapen, Mary, additional, and Gluckman, Eliane, additional

Published
2015
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10. Impact of early molecular response in children with chronic myeloid leukemia treated in the French Glivec phase 4 study

Author

Millot, Frédéric, primary, Guilhot, Joelle, additional, Baruchel, André, additional, Petit, Arnaud, additional, Bertrand, Yves, additional, Mazingue, Françoise, additional, Lutz, Patrick, additional, Vérité, Cecile, additional, Berthou, Christian, additional, Galambrun, Claire, additional, Sirvent, Nicolas, additional, Yakouben, Karima, additional, Schmitt, Claudine, additional, Gandemer, Virginie, additional, Reguerre, Yves, additional, Couillault, Gérard, additional, Mechinaud, Françoise, additional, and Cayuela, Jean-Michel, additional

Published
2014
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11. MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

Author

Nehme, Nadine T, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Debeurme, Franck, André-Schmutz, Isabelle, Lim, Annick, Nitschke, Patrick, Rieux-Laucat, Frédéric, Lutz, Patrick, Picard, Capucine, Mahlaoui, Nizar, Fischer, Alain, de Saint Basile, Geneviève, Nehme, Nadine T, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Debeurme, Franck, André-Schmutz, Isabelle, Lim, Annick, Nitschke, Patrick, Rieux-Laucat, Frédéric, Lutz, Patrick, Picard, Capucine, Mahlaoui, Nizar, Fischer, Alain, and de Saint Basile, Geneviève

Abstract

The molecular mechanisms that underlie T-cell quiescence are poorly understood. In the present study, we report a primary immunodeficiency phenotype associated with MST1 deficiency and primarily characterized by a progressive loss of naive T cells. The in vivo consequences include recurrent bacterial and viral infections and autoimmune manifestations. MST1-deficient T cells poorly expressed the transcription factor FOXO1, the IL-7 receptor, and BCL2. Conversely, FAS expression and the FAS-mediating apoptotic pathway were up-regulated. These abnormalities suggest that increased cell death of naive and proliferating T cells is the main mechanism underlying this novel immunodeficiency. Our results characterize a new mechanism in primary T-cell immunodeficiencies and highlight a role of the MST1/FOXO1 pathway in controlling the death of human naive T cells.

Published
2012

12. Imatinib Has a Negative Impact On Growth In Children With Previously Untreated Chronic Myeloid Leukaemia (CML) In Early Chronic Phase (CP): Results Of The French National Study

Author

Millot, Frédéric, primary, Guilhot, Joelle, additional, Baruchel, Andre, additional, Petit, Arnaud, additional, Leblanc, Thierry, additional, Bertrand, Yves, additional, Mazingue, Françoise, additional, Lutz, Patrick, additional, Vérité, Cécile, additional, Berthou, Christian, additional, Galambrun, Claire, additional, Sirvent, Nicolas, additional, Yacouben, Karima, additional, Chastagner, Pascal, additional, Gandemer, Virginie, additional, Reguerre, Yves, additional, Couillaud, Gérard, additional, and Cayuela, Jean-Michel, additional

Published
2013
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13. Hematopoietic Stem Cell Transplantation In Relapsed ALK + Anaplastic Large Cell Lymphoma Of Children and adolescent : A Study On Behalf Of The Sfce and SFGM-TC

Author

Strullu, Marion, primary, Thomas, Caroline, additional, Raus, Nicole, additional, Paillard, Catherine, additional, Bertrand, Yves, additional, Jubert, Charlotte, additional, De La Tour, Regis Peffaut, additional, Lutz, Patrick, additional, Dalle, Jean-Hugues, additional, Lamant, Laurence, additional, Michel, Gerard, additional, and Brugieres, Laurence, additional

Published
2013
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14. Sickle Cell Anemia and HSCT: Relation Between ATG, Chimerism, Gvhd and Outcome In Myeloablative Genoidentical Transplants For The SFGM-TC

Author

Bernaudin, Francoise, primary, Bories, Dominique, additional, Dalle, Jean-Hugues, additional, Robin, Marie, additional, Peffault de Latour, Regis, additional, Neven, Benedicte, additional, Bertrand, Yves, additional, Pondarre, Corinne, additional, Vannier, Jean-Pierre, additional, Yakouben, Karima, additional, Kuentz, Mathieu, additional, Cordonnier, Catherine, additional, Dhedin, Nathalie, additional, Thuret, Isabelle, additional, Lutz, Patrick, additional, Gluckman, Eliane, additional, and Socié, Gérard, additional

Published
2013
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15. Molecular Responses At 3 Months Are Associated With a Better Subsequent Molecular response and Outcome In Children and Adolescents With CML In Chronic Phase: Results Of a Retrospective Analysis From The French Glivec Phase 4 Study

Author

Millot, Frédéric, primary, Guilhot, Joelle, additional, Baruchel, André, additional, Petit, Arnaud, additional, Leblanc, Thierry, additional, Bertrand, Yves, additional, Mazingue, Françoise, additional, Lutz, Patrick, additional, Vérité, Cécile, additional, Berthou, Christian, additional, Galambrun, Claire, additional, Sirvent, Nicolas, additional, Yacouben, Karima, additional, Chastagner, Pascal, additional, Gandemer, Virginie, additional, Reguerre, Yves, additional, Couillaud, Gérard, additional, and Cayuela, Jean-Michel, additional

Published
2013
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16. Outcomes After Reduced-Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation (allo-SCT) In 163 Pediatric Patients (<18 years old): A Retrospective Study On Behalf Of The SFGM-TC

Author

Strullu, Marion, primary, Labopin, Myriam, additional, De La Tour, Regis Peffaut, additional, Salmon, Alexandra, additional, Dalle, Jean-Hugues, additional, Fegueux, Nathalie, additional, Paillard, Catherine, additional, Michel, Gerard, additional, Rohrlich, Pierre, additional, Bertrand, Yves, additional, Jubert, Charlotte, additional, Beguin, Yves, additional, Cardine, Aude-Marie, additional, Guillerm, Gaelle, additional, Bourhis, Jean-Henri, additional, Lutz, Patrick, additional, Raus, Nicole, additional, Rialland, Fanny, additional, Mohty, Mohamad, additional, and Chevallier, Patrice, additional

Published
2013
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17. Hyperdiploidy with 58-66 chromosomes in childhood B-acute lymphoblastic leukemia is highly curable: 58951 CLG-EORTC results

Author

Dastugue, Nicole, primary, Suciu, Stefan, additional, Plat, Geneviève, additional, Speleman, Frank, additional, Cavé, Hélène, additional, Girard, Sandrine, additional, Bakkus, Marleen, additional, Pagès, Marie Pierre, additional, Yakouben, Karima, additional, Nelken, Brigitte, additional, Uyttebroeck, Anne, additional, Gervais, Carine, additional, Lutz, Patrick, additional, Teixeira, Manuel R., additional, Heimann, Pierre, additional, Ferster, Alice, additional, Rohrlich, Pierre, additional, Collonge, Marie Agnès, additional, Munzer, Martine, additional, Luquet, Isabelle, additional, Boutard, Patrick, additional, Sirvent, Nicolas, additional, Karrasch, Matthias, additional, Bertrand, Yves, additional, and Benoit, Yves, additional

Published
2013
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18. Low CNS Relapse Incidence without Radiotherapy and Improvement of Outcome: Results of Subsequent EORTC-CLG 58881 and 58951 Trials in Pediatric T-Cell Acute Lymphoblastic Leukemia (ALL)

Author

De Moerloose, Barbara, primary, Suciu, Stefan, additional, Ferster, Alina, additional, Mazingue, Françoise, additional, Sirvent, Nicolas, additional, Costa, Vitor, additional, Yakouben, Karima, additional, Lutz, Patrick, additional, Uyttebroeck, Anne, additional, Plantaz, Dominique, additional, Plat, Geneviève, additional, Millot, Frédéric, additional, Rohrlich, Pierre, additional, Poiree, Maryline, additional, Van der Werff Ten Bosch, Jutte, additional, Hoyoux, Claire, additional, Boutard, Patrick, additional, Cavé, Hélène, additional, Girard, Sandrine, additional, Sirvent, Francisco Bautista, additional, Benoit, Yves, additional, and Bertrand, Yves, additional

Published
2012
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19. Prolonged E. Coli Asparaginase Therapy Does Not Improve Significantly the Outcome for Children with Low and Average Risk Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin Lymphoma (NHL): Final Report of the EORTC-CLG Randomized Phase III Trial 58951

Author

Mondelaers, Veerle, primary, Suciu, Stefan, additional, De Moerloose, Barbara, additional, Ferster, Alina, additional, Mazingue, Françoise, additional, Plat, Geneviève, additional, Yakouben, Karima, additional, Uyttebroeck, Anne, additional, Lutz, Patrick, additional, Costa, Vitor, additional, Sirvent, Nicolas, additional, Rohrlich, Pierre, additional, Munzer, Martine, additional, Poiree, Maryline, additional, Boutard, Patrick, additional, Millot, Frédéric, additional, Plantaz, Dominique, additional, Maes, Philip, additional, Hoyoux, Claire, additional, Cavé, Hélène, additional, Bertrand, Yves, additional, and Benoit, Yves, additional

Published
2012
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20. MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival

Author

Nehme, Nadine T., primary, Schmid, Jana Pachlopnik, additional, Debeurme, Franck, additional, André-Schmutz, Isabelle, additional, Lim, Annick, additional, Nitschke, Patrick, additional, Rieux-Laucat, Frédéric, additional, Lutz, Patrick, additional, Picard, Capucine, additional, Mahlaoui, Nizar, additional, Fischer, Alain, additional, and de Saint Basile, Geneviève, additional

Published
2012
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21. Similar Efficacy and Toxicity Profile for Idarubicine and Mitoxantrone in Induction and Intensification Treatment of Children with Acute Myeloid Leukemia (AML) or Myelodysplasia (MDS): Long-Term Results of the EORTC-CLG Randomized Phase III Trial 58921

Author

De Moerloose, Barbara, primary, Suciu, Stefan, additional, Munzer, Martine, additional, Piette, Caroline, additional, Yakouben, Karima, additional, Margueritte, Genevieve, additional, Lutz, Patrick, additional, Uyttebroeck, Anne, additional, Rohrlich, Pierre, additional, Ferster, Alina, additional, Boutard, Patrick, additional, Dresse, Marie-Françoise, additional, Rialland, Xavier, additional, Norton, Lucilia, additional, Sirvent, Nicolas, additional, Karrasch, Matthias, additional, Benoit, Yves, additional, and Bertrand, Yves, additional

Published
2011
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22. In Childhood B-Lineage Acute Lymphoblastic Leukemia (B-ALL) with Hyperdiploidy >50 Chromosomes, Patients with 58 to 66 Chromosomes Have 99% EFS At 6-Year Follow-up: Results of the EORTC CLG 58951 Trial

Author

Dastugue, Nicole, primary, Suciu, Stefan, additional, Plat, Geneviève, additional, Speleman, Frank, additional, Cavé, Hélène, additional, Girard, Sandrine, additional, Delabesse, Emmanuelle, additional, Pagès, Marie Pierre, additional, Yakouben, Karima, additional, Nelken, Brigitte, additional, Mazingue, Francoise, additional, Hagemeijer, Anne, additional, Uyttebroeck, Anne, additional, Gervais, Carine, additional, Lutz, Patrick, additional, Teixera, Manuel, additional, Norton, Lucilia, additional, Heimann, Pierre, additional, Ferster, Alina, additional, Plessis, Ghislaine, additional, Boutard, Patrick, additional, Collonge, Marie Agnès, additional, Rohrlich, Pierre, additional, Luquet, Isabelle, additional, Munzer, Martine, additional, Sirvent, Nicolas, additional, Plantaz, Dominique, additional, Herens, Christian, additional, Hoyoux, Claire, additional, Karrasch, Matthias, additional, Bertrand, Yves, additional, and Benoit, Yves, additional

Published
2011
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23. The Prognosis of Children Acute Lymphoblastic Leukemia (ALL) with Minimal Residual Disease (MRD) ≥10-2 After Induction (TP1) Depends on the Prephase Response and on the Level of the MRD After Consolidation (TP2): Results of the 58951EORTC Trial

Author

Bertrand, Yves, primary, Suciu, Stefan, additional, Grardel, Nathalie, additional, Bakkus, Marleen, additional, Mazingue, Francoise, additional, Yacouben, Karima, additional, Uyttebroeck, Anne, additional, Lutz, Patrick, additional, Plantaz, Dominique, additional, Girard, Sandrine, additional, Dastugue, Nicole, additional, Benoit, Yves, additional, and Cavé, Hélène, additional

Published
2011
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24. Related Myeloablative Stem Cell Transplantation (SCT) to Cure Sickle Cell Anemia (SCA): Update of French Results

Author

Bernaudin, Francoise, primary, Robin, Marie, additional, Ferry, Christèle, additional, Yacouben, Karima, additional, Dalle, Jean-Hugues, additional, Latour, Régis Peffault de, additional, Bertrand, Yves, additional, Pondarre, Corinne, additional, Kuentz, Mathieu, additional, Vannier, Jean-Pierre, additional, Fischer, Alain, additional, Thuret, Isabelle, additional, Lutz, Patrick, additional, Bordigoni, Pierre, additional, Rohrlich, Pierre, additional, Stephan, Jean-Louis, additional, Dhedin, Nathalie, additional, Vernant, Jean Paul, additional, Cahn, Jean-Yves, additional, Demeocq, Francois, additional, Rio, Bernard, additional, Bories, Dominique, additional, Gluckman, Eliane, additional, and Socié, Gérard, additional

Published
2010
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25. Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation: Results of a Prospective Multicenter Open French Study In High-Risk pediatrics

Author

Paillard, Catherine, primary, Lutz, Patrick, additional, Leverger, Guy, additional, Michel, Gerard, additional, Bordigoni, Pierre, additional, Dalle, Jean-Hugues, additional, Bertrand, Yves, additional, Sirvent, Anne, additional, Rohrlich, Pierre, additional, Vannier, Jean-Pierre, additional, Plantaz, Dominique, additional, Jubert, Charlotte, additional, Bruno, Benedicte, additional, Gandemer, Virginie, additional, Dore, Eric, additional, Isfan, Florentina, additional, Merlin, Etienne, additional, Rochette, Emmanuelle, additional, Halle, Pascale, additional, Demeocq, Francois, additional, and Kanold, Justyna, additional

Published
2010
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26. Dexamethasone(DEX)(6mg/sm/d) and Prednisolone(PRED)(60mg/sm/d) in Induction Therapy of Childhood ALL Are Equally Effective: Results of the 2nd Interim Analysis of EORTC Trial 58951

Author

Bertrand, Yves, primary, Suciu, Stefan, additional, Benoit, Yves, additional, Robert, Alain, additional, Nelken, Brigitte, additional, Uyttebroeck, Anne, additional, Lutz, Patrick, additional, Ferster, Alice, additional, Baruchel, Andre, additional, Norton, Lucilia, additional, Margueritte, Geneviève, additional, Rohrlich, Pierre-Simon, additional, Munzer, Martine, additional, Plantaz, Dominique, additional, Millot, Frédéric, additional, Boutard, Patrick, additional, Sirvent, Nicolas, additional, Hoyoux, Claire, additional, Baila, Liliana, additional, and Otten, Jacques, additional

Published
2008
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27. Improved Outcome with Pulses of Vincristine and Steroids in Continuation Therapy of Children with Average Risk Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin Lymphoma (NHL): Final Report of the EORTC Randomized Phase III Trial 58951

Author

De Moerloose, Barbara, primary, Suciu, Stefan, primary, Bertrand, Yves, primary, Mazingue, Francoise, primary, Robert, Alain, primary, Uyttebroeck, Anne, primary, Yacouben, Karima, primary, Ferster, Alina, primary, Margueritte, Geneviève, primary, Lutz, Patrick, primary, Munzer, Martine, primary, Sirvent, Nicolas, primary, Norton, Lucilia, primary, Boutard, Patrick, primary, Plantaz, Dominique, primary, Millot, Frédéric, primary, Philippet, Pierre, primary, Baila, Liliana, primary, Benoit, Yves, primary, and Otten, Jacques, primary

Published
2008
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28. Prognostic Significance of Central Nervous System (CNS) Status of Children with Acute Lymphoblastic Leukemia (ALL) Treated without Cranial Irradiation: Results of European Organization for Research and Treatment of Cancer (EORTC) Children Leukemia Group Study 58951

Author

Sirvent, Nicolas, primary, Suciu, Stefan, primary, Benoit, Yves, primary, Bertrand, Yves, primary, Nelken, Brigitte, primary, Robert, Alain, primary, Uyttebroeck, Anne, primary, Lutz, Patrick, primary, Ferster, Alina, primary, Yacouben, Karima, primary, Norton, Lucilia, primary, Margueritte, Geneviève, primary, Munzer, Martine, primary, Plantaz, Dominique, primary, Millot, Frédéric, primary, Boutard, Patrick, primary, Philippet, Pierre, primary, Hoyoux, Claire, primary, Baila, Liliana, primary, and Otten, Jacques, primary

Published
2008
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30. Imatinib Is Efficient but Has a Negative Impact On Growth in Children with Previously Untreated chronic Myelogenous Leukaemia (CML) in Early Chronic Phase (CP): Results of the French National Phase IV Trial

Author

Christine Edan, Gérard Couillaud, Yves Bertrand, Claire Galambrun, Lutz Patrick, François Guilhot, Yves Reguerre, Joelle Guilhot, Thierry Leblanc, Arnaud Petit, Jean-Michel Cayuela, Pierre Bordigoni, Karima Yacouben, André Baruchel, Christian Berthoux, Frédéric Millot, Cécile Vérité, Frédéric Bernard, and Françoise Mazingue

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Immunology, Imatinib, Cell Biology, Hematology, Blastic Phase, Neutropenia, medicine.disease, Biochemistry, Gastroenterology, Hematologic Response, Discontinuation, Median follow-up, Internal medicine, medicine, Adverse effect, business, Complete Hematologic Response, medicine.drug
Abstract

Abstract 863 Aims: In order to investigate the efficacy and the safety of imatinib in children and adolescents with untreated Philadelphia-positive CML, the CML working party of the Société Française des Cancers de l'enfant (SFCE) conducted an open label, multicentric phase IV study trial (Clinical Trials.gov.NCT00845221). Patients and methods. Patients less than 18 yrs of age with newly diagnosed CP CML were eligible. Imatinib was administered orally at a dose of 260 mg/m2 which is equivalent in terms of drug exposure to the total dose of 400 mg in adults. Forty four children (64% boys) with a median age of 11.5 yrs (range 10 months-17 yrs) have been enrolled from 15 French pediatric centres between July 2004 and December 2008. Side effects were reported prospectively using the NIH CTCv2.0 criteria. Results. Median follow up is currently 17 months (range:1-67). The complete hematologic response rate was 86% and 98% (ITT) at 3 months and 6 months, respectively. The rate of complete cytogenetic response (CCyR) was 62% (ITT) at 12 months. The rate of major molecular response (MMR) defined as a BCR-ABL/ABL ratio ≤ 0.1% according to the International Scale was 34% (ITT) at 12 months. The median daily dose of imatinib was close to the intended doses, 250 mg/m2 (range 176-405) with a median treatment duration of 16 months (2 w to 67 mo). Three pts (7%) had a dose reduction of more than 25% of the theoretic dose. Nine pts (20%) interrupted imatinib temporarily at least once for a median duration of dose interruption of 12 days (range 2-70). Ten pts (23%) discontinued imatinib. The reasons for discontinuation were the following: allogeneic HSCT in CCyR or MMR (2 pts) according to the investigator choice, adverse event (2 pts: muscle pain 1 pt, liver enzyme elevation 1 pt), disease progression or failure (6 pts: loss of CHR [L248V mutation] 1pt, loss of CCyR [L384M mutation] 1pt, no cytogenetic response 1 pt, no molecular response 1 pt, loss of MMR 2 pts). One of them (loss of hematologic response) transformed to blastic phase shortly after coming off study and died. Grade III or IV toxicity was recorded in 14 pts (32%). GradeIII-IV hematologic toxicity was recorded in 8 pts (18%) including neutropenia in 18% and thrombocytopenia in 5%. Nine pts (21%) developed grade III or IV non-hematologic toxicity: muscle pain (2.5%), arthralgia (5%), weight gain (13%), liver enzyme (GOT/GPT) increase (6.5%). Change of body height was observed during the first year of treatment with imatinib in the 22 pts with a sufficient follow-up: a significant decrease of height standard deviation scores (SDS) was observed with a median of the difference of -0.37 (range, -1.09 to +0.14)(p Conclusion. Imatinib is efficient in children and adolescent with previously untreated CML in early chronic phase. However, we report for the first time, a negative impact of imatinib on the growth in a cohort of children and adolescents treated with imatinib. Disclosures: No relevant conflicts of interest to declare.

Published
2009
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31. Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease

Author

Bernaudin, Françoise, primary, Socie, Gérard, additional, Kuentz, Mathieu, additional, Chevret, Sylvie, additional, Duval, Michel, additional, Bertrand, Yves, additional, Vannier, Jean-Pierre, additional, Yakouben, Karima, additional, Thuret, Isabelle, additional, Bordigoni, Pierre, additional, Fischer, Alain, additional, Lutz, Patrick, additional, Stephan, Jean-Louis, additional, Dhedin, Nathalie, additional, Plouvier, Emmanuel, additional, Margueritte, Geneviève, additional, Bories, Dominique, additional, Verlhac, Suzanne, additional, Esperou, Hélène, additional, Coic, Lena, additional, Vernant, Jean-Paul, additional, and Gluckman, Eliane, additional

Published
2007
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32. Prognostic Significance of Blasts with/without Pleiocytosis in the Cerebro-Spinal Fluid (CSF) of Children with Acute Lymphoblastic Leukemia (ALL) Treated without Cranial Irradiation: Results of European Organization for Research and Treatment of Cancer (EORTC) Children Leukemia Group Study 58881.

Author

Sirvent, Nicolas, primary, Suciu, Stefan, additional, Rialland, Xavier, additional, Robert, Alain, additional, Mazingue, Francoise, additional, Millot, Frederic, additional, De Moerloose, Barbara, additional, Ferster, Alice, additional, Rohrlich, Pierre, additional, Norton, Lucilia, additional, Lescoeur, Brigitte, additional, Dresse, Marie-Francoiseçoise, additional, Lutz, Patrick, additional, Baila, Liliana, additional, Behar, Catherine, additional, Bertrand, Yves, additional, and Otten, Jacques, additional

Published
2006
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33. Unrelated Allogeneic Stem Cell Transplantation for Severe Acquired Aplastic Anemia: Has Outcome Improved?.

Author

Maury, Sebastien, primary, Balere-Appert, M.-Lorraine, additional, Chir, Zina, additional, Boiron, J.-Michel, additional, Galambrun, Claire, additional, Yakouben, Karima, additional, Bordigoni, Pierre, additional, Marie-Cardine, Aude, additional, Milpied, Noel, additional, Kanold, Justina, additional, Maillard, Natacha, additional, Bourhis, J.-Henri, additional, Fischer, Alain, additional, Lutz, Patrick, additional, Michallet, Mauricette, additional, Blaise, Didier, additional, Cordonnier, Catherine, additional, Raffoux, Colette, additional, and Socie, Gerard, additional

Published
2006
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34. Treatment outcome in infant acute lymphoblastic leukemia

Author

Ferster, Alina, primary, Benoit, Yves, additional, Francotte, Nadine, additional, Dresse, Marie-Françoise, additional, Uyttebroeck, Anne, additional, Plouvier, Emmanuel, additional, Thyss, Antoine, additional, Lutz, Patrick, additional, Marguerite, Geneviève, additional, Behar, Catherine, additional, Mazingue, Françoise, additional, Boutard, Patrick, additional, Millot, Frederic, additional, Rialland, Xavier, additional, Mechinaud, Françoise, additional, Norton, Lucilia, additional, Robert, Alain, additional, Otten, Jacques, additional, Vilmer, Etienne, additional, Philippe, Noel, additional, Waterkeyn, Christine, additional, and Suciu, Stefan, additional

Published
2000
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35. Confounding by indication is unlikely to explain the higher inhibitor incidence in boys treated with a recombinant FVIII product.

Author

Calvez, Thierry, Chambost, Hervé, Lutz, Patrick, Rothschild, Chantal, and Goudemand, Jenny

Subjects
*HEMOPHILIA, *BLOOD coagulation factor VIII
Abstract

A response from the authors of the article "Recombinant factor VIII products and inhibitor development in previously untreated boys with severe hemophilia A" is presented.

Published
2015
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