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Your search keyword '"Gluud, Maria"' showing total 5 results
Start Over Author "Gluud, Maria" Publisher american society of hematology
5 results on '"Gluud, Maria"'

1. Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome

Author

Vadivel, Chella Krishna, primary, Willerslev-Olsen, Andreas, additional, Namini, Martin R. J., additional, Zeng, Ziao, additional, Yan, Lang, additional, Danielsen, Maria, additional, Gluud, Maria, additional, Pallesen, Emil M. H., additional, Wojewoda, Karolina, additional, Osmancevic, Amra, additional, Hedebo, Signe, additional, Chang, Yun-Tsan, additional, Lindahl, Lise M., additional, Koralov, Sergei B., additional, Geskin, Larisa J., additional, Bates, Susan E., additional, Iversen, Lars, additional, Litman, Thomas, additional, Bech, Rikke, additional, Wobser, Marion, additional, Guenova, Emmanuella, additional, Kamstrup, Maria R., additional, Ødum, Niels, additional, and Buus, Terkild B., additional

Published
2024
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2. Malignant T cells induce skin barrier defects through cytokine-mediated JAK/STAT signaling in cutaneous T-cell lymphoma

Author

Gluud, Maria, primary, Pallesen, Emil M. H., additional, Buus, Terkild B., additional, Gjerdrum, Lise Mette Rahbek, additional, Lindahl, Lise M., additional, Kamstrup, Maria R., additional, Bzorek, Michael, additional, Danielsen, Maria, additional, Bech, Rikke, additional, Monteiro, Madalena N., additional, Blümel, Edda, additional, Willerslev-Olsen, Andreas, additional, Lykkebo-Valløe, Anders, additional, Vadivel, Chella Krishna, additional, Krejsgaard, Thorbjørn, additional, Bonefeld, Charlotte Menne, additional, Geisler, Carsten, additional, Becker, Jürgen C., additional, Koralov, Sergei B., additional, Iversen, Lars, additional, Litman, Thomas, additional, Woetmann, Anders, additional, and Ødum, Niels, additional

Published
2023
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3. Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma

Author

Lindahl, Lise M., primary, Willerslev-Olsen, Andreas, additional, Gjerdrum, Lise M. R., additional, Nielsen, Pia R., additional, Blümel, Edda, additional, Rittig, Anne H., additional, Celis, Pamela, additional, Herpers, Bjorn, additional, Becker, Jürgen C., additional, Stausbøl-Grøn, Birgitte, additional, Wasik, Mariusz A., additional, Gluud, Maria, additional, Fredholm, Simon, additional, Buus, Terkild B., additional, Johansen, Claus, additional, Nastasi, Claudia, additional, Peiffer, Lukas, additional, Kubat, Linda, additional, Bzorek, Michael, additional, Eriksen, Jens O., additional, Krejsgaard, Thorbjørn, additional, Bonefeld, Charlotte M., additional, Geisler, Carsten, additional, Mustelin, Tomas, additional, Langhoff, Erik, additional, Givskov, Michael, additional, Woetmann, Anders, additional, Kilian, Mogens, additional, Litman, Thomas, additional, Iversen, Lars, additional, and Odum, Niels, additional

Published
2019
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4. Single-cell heterogeneity in Sézary syndrome

Author

Buus, Terkild Brink, Willerslev-Olsen, Andreas, Fredholm, Simon, Blumel, Edda, Nastasi, Claudia, Gluud, Maria, Hu, Tengpeng, Lindahl, Lise M., Iversen, Lars, Fogh, Hanne, Gniadecki, Robert, Litvinov, Ivan V., Persson, Jenny L., Bonefeld, Charlotte Menne, Geisler, Carsten, Christensen, Jan Praysgaard, Krejsgaard, Thorbjorn, Litman, Thomas, Woetmann, Anders, Odum, Niels, Buus, Terkild Brink, Willerslev-Olsen, Andreas, Fredholm, Simon, Blumel, Edda, Nastasi, Claudia, Gluud, Maria, Hu, Tengpeng, Lindahl, Lise M., Iversen, Lars, Fogh, Hanne, Gniadecki, Robert, Litvinov, Ivan V., Persson, Jenny L., Bonefeld, Charlotte Menne, Geisler, Carsten, Christensen, Jan Praysgaard, Krejsgaard, Thorbjorn, Litman, Thomas, Woetmann, Anders, and Odum, Niels

Abstract

Sezary syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphoma (CTCL) with a median life expectancy of less than 4 years. Although initial treatment responses are often good, the vast majority of patients with SS fail to respond to ongoing therapy. We hypothesize that malignant T cells are highly heterogeneous and harbor subpopulations of SS cells that are both sensitive and resistant to treatment. Here, we investigate the presence of single-cell heterogeneity and resistance to histone deacetylase inhibitors (HDACi) within primary malignant T cells from patients with SS. Using single-cell RNA sequencing and flow cytometry, we find that malignant T cells from all investigated patients with SS display a high degree of single-cell heterogeneity at both the mRNA and protein levels. We show that this heterogeneity divides the malignant cells into distinct subpopulations that can be isolated by their expression of different surface antigens. Finally, we show that treatment with HDACi (suberanilohydroxamic acid and romidepsin) selectively eliminates some subpopulations while leaving other subpopulations largely unaffected. In conclusion, we show that patients with SS display a high degree of single-cell heterogeneity within the malignant T-cell population, and that distinct subpopulations of malignant T cells carry HDACi resistance. Our data point to the importance of understanding the heterogeneous nature of malignant SS cells in each individual patient to design combinational and new therapies to counter drug resistance and treatment failure.

Published
2018
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5. Single-cell heterogeneity in Sézary syndrome

Author

Buus, Terkild Brink, primary, Willerslev-Olsen, Andreas, additional, Fredholm, Simon, additional, Blümel, Edda, additional, Nastasi, Claudia, additional, Gluud, Maria, additional, Hu, Tengpeng, additional, Lindahl, Lise M., additional, Iversen, Lars, additional, Fogh, Hanne, additional, Gniadecki, Robert, additional, Litvinov, Ivan V., additional, Persson, Jenny L., additional, Bonefeld, Charlotte Menné, additional, Geisler, Carsten, additional, Christensen, Jan Pravsgaard, additional, Krejsgaard, Thorbjørn, additional, Litman, Thomas, additional, Woetmann, Anders, additional, and Ødum, Niels, additional

Published
2018
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