1. Bone marrow dendritic cell aggregates associate with systemic immune dysregulation in chronic myelomonocytic leukemia
- Author
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Animesh Pardanani, Abhishek A. Mangaonkar, William J. Hogan, Ayalew Tefferi, Jose C. Villasboas, Michael Timm, Giacomo Coltro, Kaaren K. Reichard, Vivian Negron, Naseema Gangat, Mithun Vinod Shah, Ryan M. Carr, Stephen M. Ansell, Mark R. Litzow, Alexandra P. Wolanskyj-Spinner, Hassan B. Alkhateeb, Kebede H. Begna, Aref Al-Kali, Mehrdad Hefazi, Terra L. Lasho, Wilson I. Gonsalves, Theodora Anagnostou, April Chiu, Moritz Binder, Michelle A. Elliott, James W Hiebert, and Mrinal M. Patnaik
- Subjects
0301 basic medicine ,business.industry ,Chronic myelomonocytic leukemia ,chemical and pharmacologic phenomena ,Bone Marrow Cells ,Leukemia, Myelomonocytic, Chronic ,Hematology ,Dendritic cell ,Dendritic Cells ,Immune dysregulation ,medicine.disease_cause ,medicine.disease ,Stimulus Report ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Bone Marrow ,030220 oncology & carcinogenesis ,hemic and lymphatic diseases ,Immunology ,medicine ,Humans ,Bone marrow ,business - Abstract
Key Points Systemic immune microenvironment signatures in CMML indicate an altered T- and natural killer cell balance. CMML bone marrow dendritic cell aggregates associate with disease progression and systemic regulatory T-cell phenotypic switch.
- Published
- 2020