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Manipulation of hematopoietic cells to expand output while maintaining stem-cell potential has been an elusive goal of experimental hematology. The development of a system using a chemically induced dimerizer and modified thrombopoietin receptor has now allowed the expansion of primitive hematopoiesis without sacrificing stem cells.

To the Editor: The term “stochastic” has been used and abused in connection with experimental hematology for nearly 40 years. Most recently, it has resurfaced in the inaugural “Controversy in Hematology” between Metcalf[1][1] and Enver et al.[2][2] In view of the obvious importance of the

The debate about hematopoietic stem cell numbers and productive capacity is relevant to many areas of clinical and experimental hematology. Recently, Abkowitz et al[1][1] reported that the total number of stem cells in mammals is conserved so that mice, cats, humans, and possibly elephants have the

1. The findings obtained by the study of splenic aspirations in 140 patients are presented. Diagnostically they were most helpful in myeloid metaplasia, lymphoma, kala-azar, and Gaucher’s disease. 2. The findings were of particular theoretical interest in multiple myeloma and sickle cell anemia. This method of investigation could be extended to elucidating further the role of the spleen in other diseases. 3. No morbidity was encountered in this series. If certain precautions are observed, splenic puncture is a safe procedure, and should be undertaken in patients with undiagnosed splenomegaly.