1. Prognostic Factors in Primary Breast Sarcomas: A Series of Patients With Long-Term Follow-Up
- Author
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Laurent Zelek, Antonio Llombart-Cussac, X. Pivot, C. Le Pechoux, P. Terrier, F. Rochard, A. Le Cesne, Marc Spielmann, Thomas Tursz, and Jean-Marc Guinebretière
- Subjects
Adult ,Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,Breast Sarcoma ,Adolescent ,Mammary gland ,Population ,Breast Neoplasms ,Gastroenterology ,Disease-Free Survival ,Medical Records ,Internal medicine ,medicine ,Humans ,education ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,education.field_of_study ,business.industry ,Cancer ,Sarcoma ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Oncology ,Disease Progression ,Female ,Histopathology ,business - Abstract
Purpose: To describe the pathologic characteristics and prognostic factors of primary breast sarcomas (PBSs). Patients and Methods: We reviewed the clinical records and pathologic slides of 83 women with PBS treated in our institution between 1954 and 1991, with a median follow-up of 7.8 years. The majority of patients had undergone surgical treatment. Results: The main histologic type was malignant fibrohistiocytoma (n = 57). For the whole population, the 10-year overall survival (OS) and disease-free survival (DFS) rates were 62% and 50%, respectively. For Fédération Nationale des Centres de Lutte Contre le Cancer grade 1, 2, and 3 tumors, the 10-year OS and DFS rates were 82% and 61%, 62% and 51%, and 36% and 25%, respectively (P = .00007 and .004, respectively). For tumors measuring less than 5 cm, 5 to 10 cm, and more than 10 cm, the 10-year OS and DFS rates were 76% and 66%, 68% and 55%, and 28% and 15%, respectively (P = .002 and .009, respectively). In the multivariate analysis, the tumor size and histologic grade were correlated with the 10-year DFS rate (P = .04 and .01, respectively), but only the histologic grade was correlated with OS (P = .01). Angiosarcoma was the only histologic type significantly associated with a poorer outcome in the multivariate analysis. Conclusion: PBSs have the same clinical history and prognostic factors as sarcomas arising at other sites. Therefore, it is legitimate to use a similar treatment strategy for PBS as for other sarcomas.
- Published
- 2003