1. Increased cardiovascular risks associated with primary androgen deprivation therapy versus radical prostatectomy among patients with localized prostate cancer
- Author
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A. Oliver Sartor, Jinan Liu, Lizheng Shi, and Richard A. Culbertson
- Subjects
Oncology ,Gynecology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Prostatectomy ,medicine.medical_treatment ,Disease ,medicine.disease ,Androgen deprivation therapy ,Prostate cancer ,Internal medicine ,medicine ,cardiovascular diseases ,business - Abstract
e15130 Background: We examined whether primary androgen deprivation therapy (PADT), as compared to radical prostatectomy (RP), was associated with cardiovascular disease and death. Methods: Male patients with localized prostate cancer were identified in the SEER-Medicare (01/1998-12/2007). PADT patients were matched to the RP patients via propensity score. Cardiovascular risks ((i.e., ischemic heart disease (IHD), congestive heart failure (CHF), or cerebrovascular disease) were examined by Cox (PH) model; cardiovascular death by Fine & Gray competing risk. Important independent variables were controlled for. Results: The baseline variables were comparable. For the sample without cardiovascular disease (CVD) history, significantly increased risks for IHD, CHF, and aggregate risk of CVD were found in PADT group (all p-values 0.05); for the sample with CVD history, all the risks aforementioned were significantly increased in PADT group (all p-values
- Published
- 2012
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