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3631 Background: An mRNA gene expression methodology testing noninvasive rectal swab samples for a panel of 16 genes, representing 4 metabolic pathways, has shown promise for detecting colon and rectal cancers in pilot studies. To test the screening potential of this methodology, we conducted a case-controlled, single-center study using samples collected from patients with a negative screening colonoscopy (Controls; n = 71) and from patients with colorectal cancer (CRC; n = 38). Methods: Controls were defined as polyp- and cancer-free patients with no family history of CRC. Rectal swabs were collected, coded, preserved in RNAProtect O solution (Qiagen), and RNA was isolated using RNeasy mini kit (Qiagen). Real time RT-PCR using reverse transcriptase (Invitrogen) and random primers and Oligo (dT) was performed on samples pretreated with RNAase-free DNase. PCR amplification with specific oligonucleotide primers was performed using Applied Biosystems 7500 Fast Real-Time PCR Systems for 16 different markers i...

9591 Background: California Cancer Registry data from 1997–2001 indicate age-adjusted breast cancer mortality rates (per 100,000) for San Francisco County are highest for African Americans (AA; 43)...